Investigating Stakeholder Perceptions of ISO Management Systems in the UK Agricultural Sector

This paper considered perceptions from a relatively small sample of case studies but acknowledges other respondents views have been triangulated to an extent that verifies the samples used are representative of the UK agricultural supply chain. The present study provides a starting-point for further research into the adoption and uptake of ISO management systems standards in the UK agricultural sector and its supply chain. Therefore this paper does not explore the relationships between adoption of ISO management systems and the impact of them it rather explores perceptions of different ISO management systems from stakeholders viewpoints. Following an extensive review of stakeholder perceptions this paper concludes that the uptake of ISO management systems in the UK will continue and more areas of the agriculture supply chain will feel obliged to certify their management systems to a wider range of standards than just the well known quality management and environmental management system standards.  The extensive certification of ISO management systems in the UK is well known and this paper focuses on acceptance and perceptions of such standards in the UK agricultural sector. The research identified a lack of understanding and hence encourages agricultural specialists, teachers and policy makers to provide information to the agricultural sector regarding the value and scope of ISO management systems in supporting best practice and identification of regulatory compliance issues. This paper is significant in that it has acknowledged an uptake and trend in certification of management systems within the agricultural sector in the UK but has identified a lack of understanding of such systems amongst stakeholders of the agricultural supply chain. Finally, the paper clearly shows many noteworthy opportunities for further certified management systems research within the worldwide agricultural supply chain. Keywords:  ISO standards, management systems, stakeholder perceptions, agriculture, food safety, food contro

The instantaneous impact of calving and thinning on the Larsen C Ice Shelf

The Antarctic Peninsula has seen rapid and widespread changes in the extent of its ice shelves in recent decades, including the collapse of the Larsen A and B ice shelves in 1995 and 2002, respectively. In 2017 the Larsen C Ice Shelf (LCIS) lost around 10 % of its area by calving one of the largest icebergs ever recorded (A68). This has raised questions about the structural integrity of the shelf and the impact of any changes in its extent on the flow of its tributary glaciers. In this work, we used an ice flow model to study the instantaneous impact of changes in the thickness and extent of the LCIS on ice dynamics and in particular on changes in the grounding line flux (GLF). We initialised the model to a pre-A68 calving state and first replicated the calving of the A68 iceberg. We found that there was a limited instantaneous impact on upstream flow – with speeds increasing by less than 10 % across almost all of the shelf – and a 0.28 % increase in GLF. This result is supported by observations of ice velocity made before and after the calving event. We then perturbed the ice-shelf geometry through a series of instantaneous, idealised calving and thinning experiments of increasing magnitude. We found that significant changes to the geometry of the ice shelf, through both calving and thinning, resulted in limited instantaneous changes in GLF. For example, to produce a doubling of GLF from calving, the new calving front needed to be moved to 5 km from the grounding line, removing almost the entire ice shelf. For thinning, over 200 m of the ice-shelf thickness had to be removed across the whole shelf to produce a doubling of GLF. Calculating the instantaneous increase in GLF (607 %) after removing the entire ice shelf allowed us to quantify the total amount of buttressing provided by the LCIS. From this, we identified that the region of the ice shelf in the first 5 km downstream of the grounding line provided over 80 % of the buttressing capacity of the shelf. This is due to the large resistive stresses generated in the narrow, local embayments downstream of the largest tributary glaciers

Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review.

Achilles tendinopathy is the most prevalent lower limb tendinopathy, yet it remains poorly understood, with mismatches between observed structure and reported function. Recent studies have hypothesised that Achilles tendon (AT) healthy function is associated with variable deformation across the tendon width during use, focusing on quantifying sub-tendon deformation. Here, the aim of this work was to synthesise recent advances exploring human free AT tissue-level deformation during use. Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, PubMed, Embase, Scopus and Web of Science were systematically searched. Study quality and risk of bias were assessed. Thirteen articles were retained, yielding data on free AT deformation patterns. Seven were categorised as high-quality and six as medium-quality studies. Evidence consistently reports that healthy and young tendons deform non-uniformly, with the deeper layer displacing 18%-80% more than the superficial layer. Non-uniformity decreased by 12%-85% with increasing age and by 42%-91% in the presence of injury. There is limited evidence of large effect that AT deformation patterns during dynamic loading are non-uniform and may act as a biomarker of tendon health, risk of injury and rehabilitation impact. Better considered participant recruitment and improved measurement procedures would particularly improve study quality, to explore links between tendon structure, function, aging and disease in distinct populations

Characterisation of prostate lesions using transrectal shear wave elastography (SWE) ultrasound imaging:a systematic review

Background ultrasound-based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness. This systematic review aims to evaluate SWE for the detection of prostate cancer (PCa) and compare diagnostic estimates between studies reporting the detection of all PCa and clinically significant PCa (csPCa).Methods a literature search was performed using the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and CINAHL databases. Studies evaluating SWE for the detection of PCa using histopathology as reference standard were included.Results 16 studies including 2277 patients were included for review. Nine studies evaluated SWE for the detection of PCa using systematic biopsy as a reference standard at the per-sample level, with a pooled sensitivity and specificity of 0.85 (95% CI = 0.74-0.92) and 0.85 (95% CI = 0.75-0.91), respectively. Five studies evaluated SWE for the detection of PCa using histopathology of radical prostatectomy (RP) specimens as the reference standard, with a pooled sensitivity and specificity of 0.71 (95% CI = 0.55-0.83) and 0.74 (95% CI = 0.42-0.92), respectively. Sub-group analysis revealed a higher pooled sensitivity (0.77 vs. 0.62) and specificity (0.84 vs. 0.53) for detection of csPCa compared to all PCa among studies using RP specimens as the reference standard.Conclusion SWE is an attractive imaging modality for the detection of PCa

Human resource management, Lean processes and outcomes for employees: towards a research agenda

Lean management or lean thinking is a process improvement technique that along with Six Sigma is used in an increasing range of workplaces. This special issue focuses on the use of Lean in developed countries. This increased usage reflects a growing propensity for managers to launch initiatives to upgrade the efficiency and productivity of the enterprises that they manage, usually in an attempt to enhance the cost- effectiveness of operations. This special issue of the IJHRM includes eight articles in addition to this one on various aspects of the connections between lean management, human resource management (HRM) and outcomes for employees. The present article reviews the context for the increasing popularity of lean ideas among managers. Drawing on research in a range of countries, the articles in the special issue provide interesting insights into the relationships between process improvement innovations and HRM, as well as raise further important questions for research, which enable us to suggest an agenda for future research. This includes asking: what are the differences in the ways that Lean is implemented, for example the differences that may reflect industry, regional and national variables

Diversity of Tanaidacea (Crustacea: Peracarida) in the World's Oceans – How Far Have We Come?

Tanaidaceans are small peracarid crustaceans which occur in all marine habitats, over the full range of depths, and rarely into fresh waters. Yet they have no obligate dispersive phase in their life-cycle. Populations are thus inevitably isolated, and allopatric speciation and high regional diversity are inevitable; cosmopolitan distributions are considered to be unlikely or non-existent. Options for passive dispersion are discussed. Tanaidaceans appear to have first evolved in shallow waters, the region of greatest diversification of the Apseudomorpha and some tanaidomorph families, while in deeper waters the apseudomorphs have subsequently evolved two or three distinct phyletic lines. The Neotanaidomorpha has evolved separately and diversified globally in deep waters, and the Tanaidomorpha has undergone the greatest evolution, diversification and adaptation, to the point where some of the deep-water taxa are recolonizing shallow waters. Analysis of their geographic distribution shows some level of regional isolation, but suffers from inclusion of polyphyletic taxa and a general lack of data, particularly for deep waters. It is concluded that the diversity of the tanaidomorphs in deeper waters and in certain ocean regions remains to be discovered; that the smaller taxa are largely understudied; and that numerous cryptic species remain to be distinguished. Thus the number of species currently recognized is likely to be an order of magnitude too low, and globally the Tanaidacea potentially rival the Amphipoda and Isopoda in diversity

New development: 4P recommendations for implementing change, from research in hospitals

How are hospital staff involved in process improvement initiatives such as Lean? What can we learn from Lean implementation experiences about the sustainability of such initiatives? The authors considered such questions in a study of workplace change in Australia and Canada. They found that Lean is more likely to be sustained when leaders adopted the 4P recommendations presented in this article

Recent developments in non-coplanar radiotherapy.

This paper gives an overview of recent developments in non-coplanar intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). Modern linear accelerators are capable of automating motion around multiple axes, allowing efficient delivery of highly non-coplanar radiotherapy techniques. Novel techniques developed for C-arm and non-standard linac geometries, methods of optimization, and clinical applications are reviewed. The additional degrees of freedom are shown to increase the therapeutic ratio, either through dose escalation to the target or dose reduction to functionally important organs at risk, by multiple research groups. Although significant work is still needed to translate these new non-coplanar radiotherapy techniques into the clinic, clinical implementation should be prioritized. Recent developments in non-coplanar radiotherapy demonstrate that it continues to have a place in modern cancer treatment

Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice.

Introduction: Acoustic Cluster Therapy (ACT) comprises coadministration of a formulation containing microbubble-microdroplet clusters (PS101) together with a regular medicinal drug and local ultrasound (US) insonation of the targeted pathological tissue. PS101 is confined to the vascular compartment and when the clusters are exposed to regular diagnostic imaging US fields, the microdroplets undergo a phase shift to produce bubbles with a median diameter of 22 µm. Low frequency, low mechanical index US is then applied to drive oscillations of the deposited ACT bubbles to induce biomechanical effects that locally enhance extravasation, distribution, and uptake of the coadministered drug, significantly increasing its therapeutic efficacy. Methods: The therapeutic efficacy of ACT with irinotecan (60 mg/kg i.p.) was investigated using three treatment sessions given on day 0, 7, and 14 on subcutaneous human colorectal adenocarcinoma xenografts in mice. Treatment was performed with three back-to-back PS101+US administrations per session with PS101 doses ranging from 0.40-2.00 ml PS101/kg body weight (n = 8-15). To induce the phase shift, 45 s of US at 8 MHz at an MI of 0.30 was applied using a diagnostic US system; low frequency exposure consisted of 1 or 5 min at 500 kHz with an MI of 0.20. Results: ACT with irinotecan induced a strong, dose dependent increase in the therapeutic effect (R2 = 0.95). When compared to irinotecan alone, at the highest dose investigated, combination treatment induced a reduction in average normalized tumour volume from 14.6 (irinotecan), to 5.4 (ACT with irinotecan, p = 0.002) on day 27. Median survival increased from 34 days (irinotecan) to 54 (ACT with irinotecan, p = 0.002). Additionally, ACT with irinotecan induced an increase in the fraction of complete responders; from 7% to 26%. There was no significant difference in the therapeutic efficacy whether the low frequency US lasted 1 or 5 min. Furthermore, there was no significant difference between the enhancement observed in the efficacy of ACT with irinotecan when PS101+US was administered before or after irinotecan. An increase in early dropouts was observed at higher PS101 doses. Both mean tumour volume (on day 27) and median survival indicate that the PS101 dose response was linear in the range investigated