7 research outputs found

    MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair

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    Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene

    Chemical Biology and Biomedicine

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