A child with acute liver failure associated with influenza A and resolved with plasma exchange treatment

Introduction: Although liver support systems play a major role as a bridge to transplantation, they may sometimes serve as a lifesaving treatment eliminating this need

Screening for latent tuberculosis in children with immune-mediated inflammatory diseases treated with anti-tumor necrosis factor therapy: Comparison of tuberculin skin and T-SPOT tuberculosis tests

Objectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment.Patients and methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12.4 +/- 3.9 years; range, 6 to 18 years) diagnosed with immune-mediated inflammatory diseases (IMIDs) evaluated with TST and T-SPOT.TB for screening LTBI both prior to and at the sixth month of treatment with anti-TNF agents. Coherence between two tests was analyzed for TST cut-off values suggested by the local guidelines and also for different possible cut-off values of TST.Results: Tuberculin skin test was positive (>= 5 mm) in 28.1% (n=16) of patients in the screening prior to treatment and in 33.3% (n=19) at the sixth month of treatment. T-SPOT.TB test was positive in 8.8% (n=5) of patients both prior to and at the sixth month of treatment. Coherence between two tests was poor or fair when compared with all possible TST cut-off values both prior to and at the sixth month of anti-TNF therapy.Conclusion: Our results show poor coherence between T-SPOT.TB and TST for all possible cut- off values of TST. Thus, using both tests would be beneficial in screening LTBI until further studies bring new evidence on the subject

Active Surveillance of Influenza A and Other Respiratory Viruses in Children with Influenza-like-illness in Two Seasons

Introduction: The aim of this study was to asses the surveillance of influenza A/other respiratory viruses and risk factors in hospitalized children with the symptoms of influenza-like illness during two consecutive influenza seasons

Çocuklarda inek sütü alerjisi; 9 yıllık deneyim Dr Behçet Uz Çocuk Hastanesi, İzmir

Amaç: İnek sütü alerjisi çocukluk çağında en sık görülen gıda alerjisidir. Tanıda gecikme olduğunda sistemik reaksiyonlar ortaya çıkarken, yanlış tanı konulduğunda annenin ve çocuğun yetersiz beslenmesine neden olmaktadır. Diğer alerjik hastalıklar gibi besin aler- jileri de son yıllarda giderek büyüyen bir sorundur. Amacımız, inek sütü alerjisi vakala- rının özelliklerini saptamak ve sıklığının artıp artmadığını belirlemektir. Gereç ve Yöntemler: Çalışmamız retrospektif ve kesitsel olarak planlandı. Hasta verileri Pediatrik Allerji Bölümü hasta dosyalarından toplandı. Gıda alerjisi tanısı konulan has- talar arasından inek sütü alerjisi saptanan hastalar çalışmaya alındı. Bulgular: 2003-2011 yılları arasında gıda alerjisi tanısı ile takip edilen 264 olgu arasından inek sütü alerjisi tanısı alan 105 olgu çalışmaya alındı. Hastaların çoğu 2 yaşından küçük (%78,1), erkek cinsiyette (%62,9) idi ve anamnezinde süt alımını takiben kesin öykü vardı (%79,1). Olguların %75,2’sini IgE aracılı inek sütü alerjileri oluşturmaktaydı. Hastaların yarısından fazlası 2010 ve 2011 yıllarında başvuran hastalardı. Bu artışdan daha çok 1 yaş altındaki hastaların fazla olması sorumluydu (p=0.015). En sık tutulan sistem, deri (%67,5) ve multisistem (%15,7) olarak bulundu. Sonuç: Detaylı bir öykü inek sütü alerjisi tanısında önemli bir rol oynar. Yaşamın ilk yılı içinde çok sayıda hasta çeşitli semptom ve bulgularla karşımıza çıkar. Genellikle hayatı tehdit eden bir durum olmamakla birlikte beslenme, çocuğun gelişimi ve büyümesinde rol oynadığı için doğru tanı çok önemlidir.Objective: Cow’s milk allergy is the most frequent food allergy in childhood. Delayed diagnosis may cause a number of systemic dysfunctions, while incorrect diagnosis may result in deficient nutrition of the mother and the child. As in other types of allergies, food allergy is also a growing problem in recent years. Our aim was to determine the characte- ristics of our patients allergic to cow’s milk, and see if there was an increasing trend. Material and Methods: The study was of retrospective and cross-sectional design. Patient data were collected from Pediatric Allergy Department patient files. Cases of food allergy were reviewed and patients fulfilling the criteria of cow’s milk allergy were included in the study. Results: A total of 105 cases with cow’s milk allergy out of 264 food allergies who were followed up between 2003-2011 were investigated. Most of the patients were under 2 years of age (78.1%), were males (62.9%) and presented with a history of allergy (79.1%). IgE mediated cases constituted the majority (75.2%). More than half of the patients admitted in 2010 and 2011. This was mostly due to the increased number of patients less than twel- ve months of age (p=0.015). Most frequently involved system was skin (67.5%) and mul- tisystem involvement was 15.7% Conclusion: A detailed history is the key element of diagnosing cow’s milk allergy. There is a considerable number of cases within the first year of life which may present with dif- ferent signs and symptoms. Although not a life threatening situation, correct diagnosis is vital as nutrition is a key component in the development and growth of child

Cow's milk allergy in children: 9 years experience of Dr. Behcet Uz Children's hospital, Izmir

Objective: Cow's milk allergy is the most frequent food allergy in childhood. Delayed diagnosis may cause a number of systemic dysfunctions, while incorrect diagnosis may result in deficient nutrition of the mother and the child. As in other types of allergies, food allergy is also a growing problem in recent years. Our aim was to determine the characteristics of our patients allergic to cow's milk, and see if there was an increasing trend

Screening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests

Objectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment