DPPH Radical Scavenging, Phenolic and Antimicrobial Activity of Momordica charantia and Rheum ribes

Guder, Aytac/0000-0002-1190-8749WOS: 000438848100055In this study was to investigate total phenolic contents, 1, 1-Diphenyl-2-picrylhydrazyl (DPPH center dot), antimicrobial and antifungal activity by using different extract of Momordica charantia and Rheum ribes. The extraction applied to different part of Momordica charantia as husk and fruit and Rheum ribes as blossom and stem. Three different were used extraction solvent such as hexane, ethanol and water/acetic acid (1%). The highest radical scavenging activity was observed in ethanol extract of rhubarb blossom, acetic acid (1%) extract of rhubarb showed remarkable radical scavenging activity and the highest phenolic content value was observed acetic acid (1%) extracts of bitter melon. The highest antimicrobial efficacy against C. albicans was provided by the ethanol extract of the part of crust of Momordica charantia and acetic acid-water extraction of the blossom of Rheum ribes.Giresun UniversityGiresun University [FEN-BAP-A-160317-45]This study was supported by Giresun University (FEN-BAP-A-160317-45) Scientific Research Project

Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease

Introduction:Chronic kidney disease (CKD) is a widespread health problem, in which mortality is most frequently due to cardiovascular diseases. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein. MFAP4 is involved in several biological processes, particularly the maintenance of vascular integrity and extracellular matrix remodeling. Our review of the literature revealed no data concerning MFAP4 levels in CKD and its relationship with myocardial functions.Objective:The purpose of this study was therefore to investigate MFAP4 levels in CKD, parameters affecting these, and the relationship with myocardial functions.Materials and Methods:Seventy-nine CKD patients and 30 healthy controls were included in the study. Routine biochemical tests and echocardiography were performed once demographic data had been recorded. Blood specimens were collected for MFAP4 analysis, and the results were subjected to statistical analysis.Results:MFAP4 levels were significantly higher in the patient group than in the control group (p< 0.001). Doppler parameters revealed more frequent LV diastolic impairment in the patient group. Tissue Doppler systolic velocity and global longitudinal strain were significantly impaired, revealing the subclinical LV systolic dysfunction in CKD patients. MFAP4 elevation in the patient group was positively correlated with aortic root (AR), global circumferential strain (GCS), and GCS rate.Conclusion:Our results showed MFAP4 elevation in CKD for the first time in the literature, and that this elevation may be related to GCS and AR dilation. We think that, once supported by further studies, MFAP4 may constitute a marker in the evaluation of myocardial functions in CKD