Efficacy of different treatment methods in patients with myofascial pain syndrome

Purpose: Photobiomodulation therapy (PBMT) and occlusal splint therapy (OST) are treatment methods for myofascial pain dysfunction syndrome (MPS). This study evaluates the effect of PBMT and OST on pain relief and mandibular function improvement in patients with MPS. Methods: A retrospective study was conducted with the patients (35 women; age range, 18–60 years), who were treated at the Faculty of Dentistry, Trakya University, between 2017 and 2018. The patients were diagnosed with MPS and treated with PBMT (940 nm) or OST. Pain intensity and mandibular function were evaluated at the beginning of the treatments (t0), as well as 1 month (t1) and 2 months (t2) after the beginning of the treatments. Results: Mandibular function improved significantly in both the PBMT (t0–t2 = − 2.15 ± 2.23, p = 0.007) and OST groups (t0–t2 = − 2.46 ± 2.18, p = 0.005). Pain intensity values also decreased significantly over time in both the PBMT (t0–t2 = 4.15 ± 2.30, p = 0.002) and OST (t0–t2 = 4.62 ± 1.39, p = 0.001) groups. Conclusions: The tested types of PBMT and OST are effective for pain relief and mandibular function improvement in MPS. Trial registration: ClinicalTrials.gov Identifier: NCT0425790

The relationship between vitamin D level and lipid profile in patients admitted to physical medicine and rehabilitation outpatient clinic

Amaç: Kardiyovasküler (KVS) hastalıklar, dünya çapında önde gelen ölüm sebeplerindendir. Epidemiyolojik çalışmalarda serum 25 Hidroksi D vitamini (25-OH D) ile KVS hastalık risk faktörlerinden olan lipid profili arasında negatif korelasyon olduğu gösterilmiştir. Bununla birlikte 25-OH D vitamin düzeyi ile hastalık arasındaki ilişkinin nedensel olup olmadığı veya sadece yaşam tarzı ile ilişkili bir belirteç olduğu durumu belirsizdir. Vitamin D takviyesinin serum lipid profili üzerine etkileri araştıran plasebo kontrollü çalışmalar farklı sonuçlar vermiştir. Bu çalışmanın amacı serum vitamin D konsantrasyonu ile lipid profili arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Fiziksel Tıp ve Rehabilitasyon polikliniğine ağrı şikayetiyle başvuran 204 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri kaydedildi. Açlık serum 25-OH D vitamini, total kolesterol, LDL, HDL ve trigliserid konsantrasyonları ölçüldü. Bulgular: Hastaların ortalama 25-OH D düzeyleri 10.66.5 ng/mL, D vitamini eksikliği prevalansı %92.2 idi. Hastalar 25-OH D vitamin düzeylerine göre 20 ng/mL, 20-30 ng/mL ve 30 ng/mL olmak üzere 3 gruba ayrıldı. Yüksek D vitamini konsantrasyonu olan hastalarda D vitamini eksikliği olan hastalara göre serum total kolesterol, TG ve LDL düzeyleri düşük ve HDL düzeyi daha yüksek olmasına rağmen, bu fark istatistiksel olarak anlamlı değildi (p 0.05). Sonuç: D vitamini eksikliği prevalansı ve uygun olmayan lipid profilinin olumsuz etkileri göz önüne alındığında, yüksek riskli toplumlarda D vitamini durumunun incelenmesi, düzeltilmesi ve korunmasının uygun olacağı görüşündeyiz.Aim: Cardiovascular disease (CVD) is one of the leading causes of deaths worldwide. Epidemiological studies have shown an inverse association between serum 25-hydroxy vitamin D (25-OH D) and cardiovascular risk factors including lipid profile. However, it is still unclear whether 25-OH D level is causally related to the disease or is just a marker of lifestyle. Placebo-controlled trials that examined the effect of vitamin D supplementation on serum lipid profile have provided divergent results. The aim of this study is to investigate the relationship between serum vitamin D concentration and lipid profile. Materials and Methods: Two hundred and four patients admitted to physical medicine and rehabilitation outpatient clinic with the complaint of pain were included in this study. The demographic characteristics of patients were recorded. Fasting serum concentrations of 25-OH vitamin D, total cholesterol, high-density lipoprotein (HDL), low- density lipoprotein (LDL) and triglyceride were measured. Results: The mean level of 25-OH D was 10.6±6.5 ng/mL, the prevalence of vitamin D deficiency was 92.2%. Patients were classified into 3 groups according to the 25-OH vitamin D levels as 30 ng/mL. Although in patients with higher vitamin D concentration, serum levels of total cholesterol, TG, and LDL were lower and HDL was higher compared to patients with vitamin D deficiency, this association was not statistically significant (p>0.05). Conclusion: Given the prevalence of vitamin D insufficiency and the detrimental consequences of an unfavorable lipid profile, we believe that investigation, correction, and maintenance of vitamin D status may be indicated in high- risk populations

Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement

This work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosmarinus officinalis L. (Rosemary), Curcuma longa L. (Turmeric) and Fumaria officinalis L. (Fumitory) as standardized botanical dietary supplement, on mice with CCl4-induced acute liver injury. The total phenolic and flavonoid contents of Hep-X were determined as 0.125 and 0.528 mg/mL, respectively. The quercetin content was determined as 50 mu g/mL using HPLC analysis. The total antioxidant capacity showed correlation between the Hep-X concentration and percentage inhibition of free radicals. Hep-X was administered orally at 25, 50 and 100 mg/kg b.w./day against CCl4-induced hepatotoxicity in mice. The hepatic damage was measured using blood biochemical parameters. Animals upon Hep-X treatment exhibited better drug effIcacy in certain blood parameters than silymarin-treated mice. Also, Hep-X administration significantly ameliorated the liver damage by suppressing iNOS expression and apoptosis as well as by recovery of the histological structure. The obtained results suggest that Hep-X is able to significantly alleviate the hepatotoxicity induced by CCl4 in mice, which can be due to antioxidant properties of the polyherbal formulation.This study was supported by the Naturin Nutraceuticals Products Company Izmir, Turkey and Ege University, Faculty of Science (Project Number 2012/ILAM/002)Naturin Nutraceuticals Products Company Izmir, Turkey; Ege University, Faculty of Science [2012/ILAM/002