A female case with multicystic dysplastic kidney: new findings, genetic counseling, and literature review

The multicystic dysplastic kidney (MCDK) is the most common form of cystic kidney disease in children with unknown pathogenesis. Previously concomitant abnormalities such as heart, gastro-intestinal system, spine and the brain were reported with MCDK. We report a 15-day-old girl case with multicystic dysplastic kidney, distinct dysmorphic features and are view of the literature. We suggest that genetic counseling should take into consideration parental renal ultrasound and chromosome results as well as family history

Design of novel binuclear phthalocyanines formed by dioxyphenyl bridges: Synthesis and investigation of thermal and antioxidant properties

4,4_-(1,4-Phenylenebis(oxy)diphthalonitrile was synthesized by reaction of hydroquinone with 4-nitrophthalonitrile. Binuclear metallophthalocyanines 2–4 were obtained by the reaction between 4,4_-(1,4-phenylenebis(oxy)diphthalonitrile and 4-(benzo [d] [1,3] dioxol- 5-ylmethoxy)phthalonitrile in the presence of metal salts. These new compounds were characterized by using elemental analysis, FTIR, 1H-NMR and UV/Vis spectroscopic data. Thermal properties of phthalocyanines 2-4 were investigated by TG and DTA. In addition, antioxidant properties of compounds II, 3 and 4 were investigated. Their radical-scavenging capacity and chelating effects was fully studied. The maximum 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were obtained from compound 3. Chelating effects on ferrous ions were 91.6 % at concentration of 100 mgL–1 with compound II