Medical treatment in childhood metastatic adrenocortical carcinoma: case report

Adrenocortical carcinoma is a rare endocrine tumor in childhood. It is curable when it is resected totally. However, medical therapy is challenging in patients with metastatic disease. Herein, we present the response to various salvage chemotherapy modalities in addition to mitotane therapy, which were administered to a child with progressive and metastatic adrenocortical tumor. The patient has been under follow-up with progressive disease for 17 months

Cytomegalovirus pneumonia in a pediatric patient with solid tumor

Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in immunosuppressed patients. CMV infection is mostly encountered in children undergoing highdose chemotherapy and transplantation. Though the chemotherapy for solid tumor is an immunosuppressed state, CMV infection has been reported infrequently in children with solid tumors. In this paper, a child diagnosed with neuroblastoma who was treated with conventional chemotherapy and developed CMV pneumonia is presented. The patient was treated with intravenous ganciclovir in the pediatric intensive care unit, but died one week later

Testis Involvement in Neuroblastoma: Report of 3 Cases in the Turkish Pediatric Oncology Group-Neuroblastoma Study and Review of the Literature

Background: Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. Primary and secondary testicular involvement is extremely uncommon in neuroblastoma. Procedure: All children with neuroblastoma treated with the Turkish Pediatric Oncology Group (TPOG)-Neuroblastoma (NB) Study and who had testis involvement either at diagnosis or at relapse were retrospectively evaluated. A review of all cases with neuroblastoma and testis involvement in the literature was done. Results: There were 3 children with NB documented to have involvement of the testis, 2 at diagnosis, 1 at recurrence, within the 559 cases (0.5%) treated with the Turkish Pediatric Oncology Group (TPOG)-Neuroblastoma Protocol. All had advanced stage. Two were infants. A total of 57 cases of testicular or paratesticular neuroblastoma have been reported in children, and most cases represent metastases as in the 3 cases in our series. Conclusions: Neuroblastoma should be considered in the differential diagnosis of testicular mass and work-up for neuroblastoma should be done before orchiectomy. Scrotal ultrasonography should be used as the first diagnostic tool and abdominal ultrasonography shall be done additionally. Testis examination should be performed at diagnosis and regularly during follow-up for boys diagnosed with neuroblastoma. Testes may be sanctuary sites when neuroblastoma is metastatic, as is the case in leukemia

Report of a case with Hodgkin's lymphoma, tuberculosis and autoimmune hemolytic anemia

Tuberculosis has been described in association with malignancies including Hodgkin's disease (HD). In this article, a patient with diagnoses of H D, tuberculosis and hemolytic anemia is reported. Both tuberculosis and HD may present with similar symptoms and signs, and one of the diagnoses may be overlooked. The physicians should be aware of the simultaneous occurrence of both of these diseases when they are faced with initial therapeutic failure, during care of HD and tuberculosis patients