Evaluation of osseointegration of titanium alloyed implants modified by plasma polymerization

By means of plasma polymerization, positively charged, nanometre-thin coatings can be applied to implant surfaces. The aim of the present study was to quantify the adhesion of human bone cells in vitro and to evaluate the bone ongrowth in vivo, on titanium surfaces modified by plasma polymer coatings. Different implant surface configurations were examined: titanium alloy (Ti6Al4V) coated with plasma-polymerized allylamine (PPAAm) and plasma-polymerized ethylenediamine (PPEDA) versus uncoated. Shear stress on human osteoblast-like MG-63 cells was investigated in vitro using a spinning disc device. Furthermore, bone-to-implant contact (BIC) was evaluated in vivo. Custom-made conical titanium implants were inserted at the medial tibia of female Sprague-Dawley rats. After a follow-up of six weeks, the BIC was determined by means of histomorphometry. The quantification of cell adhesion showed a significantly higher shear stress for MG-63 cells on PPAAm and PPEDA compared to uncoated Ti6Al4V. Uncoated titanium alloyed implants showed the lowest BIC (40.4%). Implants with PPAAm coating revealed a clear but not significant increase of the BIC (58.5%) and implants with PPEDA a significantly increased BIC (63.7%). In conclusion, plasma polymer coatings demonstrate enhanced cell adhesion and bone ongrowth compared to uncoated titanium surfaces

The first multi-wavelength campaign of AXP 4U 0142+61 from radio to hard X-rays

For the first time a quasi-simultaneous multi-wavelength campaign has been performed on an Anomalous X-ray Pulsar from the radio to the hard X-ray band. 4U 0142+61 was an INTEGRAL target for 1 Ms in July 2005. During these observations it was also observed in the X-ray band with Swift and RXTE, in the optical and NIR with Gemini North and in the radio with the WSRT. In this paper we present the source-energy distribution. The spectral results obtained in the individual wave bands do not connect smoothly; apparently components of different origin contribute to the total spectrum. Remarkable is that the INTEGRAL hard X-ray spectrum (power-law index 0.79 +/- 0.10) is now measured up to an energy of ~230 keV with no indication of a spectral break. Extrapolation of the INTEGRAL power-law spectrum to lower energies passes orders of magnitude underneath the NIR and optical fluxes, as well as the low ~30 microJy (2 sigma) upper limit in the radio band.Comment: 6 pages, 1 figure. To be published in the proceedings of the conference "Isolated Neutron Stars: from the Interior to the Surface" (April 24-28, 2006, London, UK), eds. S. Zane, R. Turolla and D. Pag

Unveiling Soft Gamma-Ray Repeaters with INTEGRAL

Thanks to INTEGRAL's long exposures of the Galactic Plane, the two brightest Soft Gamma-Ray Repeaters, SGR 1806-20 and SGR 1900+14, have been monitored and studied in detail for the first time at hard-X/soft gamma rays. This has produced a wealth of new scientific results, which we will review here. Since SGR 1806-20 was particularly active during the last two years, more than 300 short bursts have been observed with INTEGRAL. and their characteristics have been studied with unprecedented sensitivity in the 15-200 keV range. A hardness-intensity anticorrelation within the bursts has been discovered and the overall Number-Intensity distribution of the bursts has been determined. In addition, a particularly active state, during which ~100 bursts were emitted in ~10 minutes, has been observed on October 5 2004, indicating that the source activity was rapidly increasing. This eventually led to the Giant Flare of December 27th 2004, for which a possible soft gamma-ray (>80 keV) early afterglow has been detected. The deep observations allowed us to discover the persistent emission in hard X-rays (20-150 keV) from 1806-20 and 1900+14, the latter being in a quiescent state, and to directly compare the spectral characteristics of all Magnetars (two SGRs and three Anomalous X-ray Pulsars) detected with INTEGRAL.Comment: 8 pages, 7 figures, Presented at the conference "Isolated Neutron Stars: from the Surface to the Interior", London, UK, 24-28 April 200

Soziale Integration und Politische Institutionen in Modernen Gesellschaften

Im Unterschied zu zeitgenössischen Diagnosen über den Zustand moderner Gesellschaften, geht die Analyse davon aus, daß die These der Desintegration dieser Gesellschaften empirisch völlig ungeklärt ist. Zur Durchführung von systematischen und empirischen Studien sind allererst begrifflich-theoretische Vorarbeiten nötig, zu denen die Analyse beitragen will. Es werden drei Ziele verfolgt: Erstens eine genaue Bestimmung des Begriffs der sozialen Integration. Dazu werden sechs operationale Definitionen vorgeschlagen, die sich unter anderem im Grad ihres normativen Anspruchs unterscheiden. Zweitens eine genaue Bestimmung des Begriffs der politischen Institutionen und drittens die Spezifikation eines empirisch testbaren liberalen Modells der sozialen Integration. In diesem Modell spielt die Unterstützung des politischen Institutionengefüges eines Landes eine zentrale Rolle. Die Konstruktion des Modells orientiert sich an der grundlegenden Unterscheidung eines politischen Systems in drei hierarchisch angeordnete Ebenen ' der Kultur-, Struktur- und Prozeßebene ' und konkretisiert diese Ebenen in Anlehnung an die liberale Demokratietheorie durch die Spezifikation von empirisch meßbaren Konstrukten und Zusammenhängen zwischen diesen Konstrukten.In contrast to contemporary diagnoses of the state of modern societies, this analysis assumes that the thesis of the disintegration of these societies is not empirically established at all. Systematic empirical studies require preliminary conceptual work to which this analysis contributes. The analysis sets itself three goals: firstly, it proposes a precise definition of the concept of social integration in terms of six operational definitions with different normative standards. Secondly, it suggests an accurate definition of the concept of political institutions and, thirdly, it specifies an empirically testable liberal model of social integration. In this model, support of the institutional structure of a country plays a central role. The model differentiates three levels-cultural, structural, and procedural- operationalizing them in a concrete form following liberal democratic theory. Empirically testable interrelations between the constructs are specified

An analytical performance model for active imaging systems including slant-path applications

We have implemented the approach for modeling the target acquisition performance of active imaging systems (gated viewing) introduced by the US Army Night Vision and Electronic Sensors Directorate (NVESD) and extended it to slant-path scenarios. For slant laser pulse propagation paths there are two important physical effects which have to be taken into account: the height dependency of both the atmospheric turbulence strength and the atmospheric extinction. The influence of these modifications on sensor performance has been investigated. Two theoretical daytime profiles for the atmospheric turbulence strength were considered and own measurements of Cn2 are presented