Skin capacitance imaging, a new technique for investigating the skin surface.

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides information about the skin microrelief, the level of stratum corneum hydration and the sweat gland activity. The apparatus sees and measures these parameters with a 50 microm resolution. A series of conditions have been explored using skin capacitance imaging. This review summarizes relevant findings about regional variability on the body, changes occurring with ageing, effects of a hydrating formulation, reactivity kinetics of corneocytes to surfactants, acne and skin pores characteristics, as well as hyperkeratotic dermatoses and tumours

Large scale composting model

One way to treat the organic wastes accordingly to the environmental policies is to develop biological treatment like composting. Nevertheless, this development largely relies on the quality of the final product and as a consequence on the quality of the biological activity during the treatment. Favourable conditions (oxygen concentration, temperature and moisture content) in the waste bed largely contribute to the establishment of a good aerobic biological activity and guarantee the organic matter stabilisation with limitation and control of odorous and greenhouse effect gaseous emissions. Several approaches (0D biochemical reducing, see Pommier et al. 2007, effective 1D modelling coupling transport and biochemical) have been made to understand the behaviour of such systems. In this paper we will present a 2D numerical model using Darcy scale equations for heat and mass transport coupled with a biochemical reactive scheme. Then, we will solve that system (using experimental measurements on reactivity and transport coefficients) with a commercial code (COMSOL TM). The model described here is based on the biological model presented in Trémier et al 2005 coupled with an upscale transport model detailed in Hénon 2008 which takes into account the major components of the gas phase: N₂, O₂, CO₂ and also H₂O. This is a crucial point because of: - The reaction rate, depending on the moisture content (humidity comes from the initial condition of the sludge but also from the reactive scheme because reactions produce water), - heat content, very sensitive to the evaporation rate in the sludge. It has been shown in Pujol et al 2011 that the impact of drying could be important on the reactivity but also that the pseudo component air could not be sufficient to represent the drying in the sludge. The process studied was a closed reactor composting process (180 m³ rectangular box) with positive forced aeration. The air was blown from the bottom of the reactor, via two ventilation pipes. In the upper part of the reactor, air was sucked and led to a biofilter treatment system. The treated waste was a mixture of sewage sludge and bulking agent that was composted during four weeks without turning. Several informations were recorded during the treatment like temperature evolutions at different locations (see Henon et al. 2009 for more details about the temperature recording). We have validated this code by comparing the temperatures obtained through the simulations with those recorded during the experiments. After this step of validation and a discussion on final composition of the organic matter in the experiments compared to the ones estimated by simulations, we have used this numerical model as an optimization tool. Modifying the initial, boundary and operating conditions we have been able to determine the best conditions to this particular composting process. A whole set of conditions is discussed in the paper

Collaboration over Wiki Content

IWCES'12 - The Twelfth International Workshop on Collaborative Editing SystemsInternational audienceResolving conflicts is a key issue in collaborative editing. The difficulty of this task grows with the complexity of the document structure, and most of digital documents are not simple sequences of characters. This paper offers a new ap- proach to handle conflict resolution automatically in a rich text document. This work uses Operational Transformation approach, and is based on a meaningful set of operations instead of primitive ones. This way, information about what the users precisely want to do is saved, and conflict resolution is more accurate

Enhancing rich content wikis with real-time collaboration

International audienceWikis are one of the most important tools of Web 2.0 allowing users to easily edit shared data. However, wikis offer limited support for merging concurrent contributions on the same pages. Users have to manually merge concurrent changes and there is no support for an automatic merging. Real-time collaborative editing reduces the number of conflicts as the time frame for concurrent work is very short. In this paper we propose extending wiki systems with real-time collaboration. We propose an automatic merging solution adapted for rich content wikis. Our solution is integrated into a widely used wiki system

Supporting Adaptable Granularity of Changes for Massive-scale Collaborative Editing

International audienceSince the Web 2.0 era, the Internet is a huge content editing place in which users contribute to the content they browse. Users do not just edit the content but they collaborate on this content. Such shared content can be edited by thousands of people. However, current consistency maintenance algorithms seem not to be adapted to massive collaborative updating. Shared data is usually fragmented into smaller atomic elements that can only be added or removed. Coarse-grained data leads to the possibility of conflicting updates while fine-grained data requires more metadata. In this paper we offer a solution for handling an adaptable granularity for shared data that overcomes the limitations of fixed-grained data approaches. Our approach defines data at a coarse granularity when it is created and refines its granularity only for facing possible conflicting updates on this data. We exhibit three implementations of our algorithm and compare their performances with other algorithms in various scenarios.Depuis l'ère du Web 2.0, les contenus internet sont énormément édités par de nombreux contributeurs. Ils n'éditent pas simplement, mais collaborent sur des contenus partagés, parfois à plusieurs milliers. Toutefois, les algorithmes actuels de maintien de la consistance des données ne semblent pas adaptés à la collaboration en masse. Les données partagées sont souvent découpées en petits éléments atomiques, qui peuvent être ajoutés ou supprimés. Une taille importante de ces atomes peut conduire à des conflits d'édition, tandis qu'une taille minime nécessite plus de métadonnées. Cet article propose un algorithme qui fonctionne avec une granularité adaptable pour pallier à ce problème. Nous commençons avec des éléments de grande taille, et nous les séparons en plus petits pour éviter les conflits quand nécessaire. Nous présentons trois implémentations de cet algorithme et comparons leurs performances avec d'autres, dans différents scénarios

Initial combination therapy with ambrisentan + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial

Background: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization. Methods: The effect of initial combination therapy with ambrisentan and tadalafil in AMBITION was further explored to study PAH-related hospitalization, which was not reported in the primary publication. Results: Initial combination therapy was associated with a 63% reduction in risk of PAH-related hospitalization when compared with pooled monotherapy (hazard ratio [HR] 0.372, 95% confidence interval [CI] 0.217 to 0.639, p = 0.0002). For every 9 patients treated with combination therapy vs monotherapy, 1 PAH-related hospitalization could be prevented over a 1-year period. Serious adverse events leading to hospitalization, not necessarily PAH-related, occurred in 87 of 253 (34%) and 89 of 247 (36%) of patients on combination therapy and pooled monotherapy, respectively (post-hoc summary). Conclusions: Initial combination therapy with ambrisentan and tadalafil was found to reduce the risk of PAH-related hospitalization by 63% compared with pooled monotherapy

Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: Results from the AMBITION trial

Background: The purpose of this study was to compare patients with pulmonary arterial hypertension enrolled in the AMBITION trial with (excluded from the primary analysis set [ex-primary analysis set]) and without (primary analysis set) multiple risk factors for left ventricular diastolic dysfunction. Methods: Treatment-naive patients with pulmonary arterial hypertension were randomized to once-daily ambrisentan and tadalafil combination therapy, ambrisentan monotherapy, or tadalafil monotherapy. The primary end point was time from randomization to first adjudicated clinical failure event. Results: Primary analysis set patients (n = 500), compared with ex-primary analysis set patients (n = 105), were younger (mean, 54.4 vs 62.1 years) with greater baseline 6-minute walk distance (median, 363.7 vs 330.5 meters) and fewer comorbidities (e.g., hypertension and diabetes). Treatment effects of initial combination therapy vs pooled monotherapy were directionally the same for both populations, albeit of a lower magnitude for ex-primary analysis set patients. Initial combination therapy reduced the risk of clinical failure compared with pooled monotherapy in primary analysis set patients (hazard ratio, 0.50; 95% confidence interval, 0.35-0.72), whereas the effect was less clear in ex-primary analysis set patients (hazard ratio, 0.70; 95% confidence interval, 0.35-1.37). Overall, primary analysis set patients had fewer clinical failure events (25% vs 33%), higher rates of satisfactory clinical response (34% vs 24%), and lower rates of permanent study drug withdrawal due to adverse events (16% vs 31%) than ex-primary analysis set patients. Conclusions: Efficacy of initial combination therapy vs pooled monotherapy was directionally similar for primary analysis set and ex-primary analysis set patients. However, ex-primary analysis set patients (with multiple risk factors for left ventricular diastolic dysfunction) experienced higher rates of clinical failure events and the response to combination therapy vs monotherapy was attenuated. Tolerability was better in primary analysis set than ex-primary analysis set patients

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. Methods: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits and collated via case report forms. Results: In total, 956 patients with CTEPH were included in the analysis. The most common AEs in these patients were peripheral edema/edema (11.7%), dizziness (7.5%), right ventricular (RV)/cardiac failure (7.7%), and pneumonia (5.0%). The most common SAEs were RV/cardiac failure (7.4%), pneumonia (4.1%), dyspnea (3.6%), and syncope (2.5%). Exposure-adjusted rates of hemoptysis/pulmonary hemorrhage and hypotension were low and comparable to those in the long-term extension study of riociguat (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial [CHEST-2]). Conclusion: Data from EXPERT show that in patients with CTEPH, the safety of riociguat in routine practice was consistent with the known safety profile of the drug, and no new safety concerns were identified