Nonlinear Response of Underground Duct Structures with Due Attention to Seismic Input Ground Motions

Under destructive earthquake motions, structures behave heavily in nonlinear manner that is quite different from the linear response computation. The underground structures such as tunnels, ducts are susceptible to the ground motions so that the nonlinear interaction analysis should be performed for the reliable design. In case of irregular soil profile, due to the surface wave generation, the vertical motions come out to a less negligible extent compared to the horizontal motions. The present paper has concerned with such nonlinear response evaluation of a duct structure under strong motions. The effect of the transient characteristics in the inland type and ocean type earthquake motions is investigated. The effect of the vertical component in the ground motions is also evaluated

Periostin-expressing cell-specific transforming growth factor-β inhibition in pulmonary artery prevents pulmonary arterial hypertension

Transforming growth factor beta (TGF-β) has been shown to play a critical role in pathogenesis of pulmonary arterial hypertension (PAH) although the precise role of TGF-β signaling remains uncertain. A recent report has shown that periostin (Pn) is one of the most upregulated proteins in human PAH lung compared with healthy lungs. We established type I TGF-β receptor knockout mice specifically with Pn expressing cell (Pn-Cre/Tgfb1fl/fl mice). Increases in PA pressure and pulmonary artery muscularization were induced by hypoxia of 10% oxygen for 4 weeks. Lung Pn expression was markedly induced by 4 week-hypoxia. Pn-Cre/Tgfb1fl/fl mice showed lower right ventricular pressure elevation, inhibition of PA medial thickening. Fluorescent co-immunostaining showed that Smad3 activation in Pn expressing cell is attenuated. These results suggest that TGF-β signaling in Pn expressing cell may have an important role in the pathogenesis of PAH by controlling medial thickening

Research on the factors impact on “IBASHO” consciousness, self-affirmation and life satisfaction in adolescents. : From attitude survey for youth in Tokushima

Cognition, social skill and environment are associated with mental health in adolescents. It is an important task to improve their cognition, social skill and environment in their adaptation. In this study, we examined the factors impact on “IBASHO (existential place)” consciousness, self-affirmation and life satisfaction in middle and high school students. One thousand one hundred and forty-five(study I), one thousand one hundred and eighty-two(study II) adolescents completed the questionnaire “attitude survey for youth in Tokushima”. In the study I, we analyzed the relation between “IBASHO” consciousness in the family and presence or absence of the experience at home. In study II, we analyzed the relation between the self-affirmation, life satisfaction and the question of history of life. Multiple regression analyses resulted rejected or regulative parenting had negative influence on “IBASHO” consciousness in the family. Accepted parenting had positive influence on “IBASHO” consciousness in the family. Existential destress decreased self-affirmation and life satisfaction in middle and high school students. We concluded it will be necessity to improve “IBASHO” consciousness, self-affirmation and life satisfaction in middle and high school students by means of cultivating parenting and stress coping skills

Gambling symptoms, behaviors, and cognitive distortions in Japanese university students

Background: This study was conducted to investigate the relationship between symptoms of gambling problems, gambling behaviours, and cognitive distortions among a university student population in Japan ages 20 to 29 years. We aimed to address the gap in knowledge of gambling disorders and treatment for this population. Methods: Data were obtained from 1471 Japanese undergraduate students from 19 universities in Japan. Descriptive statistics and hierarchical multivariate regression analysis were used to investigate whether the factors of gambling cognitive distortions would have predictive effects on gambling disorder symptoms. Results: Results indicated that 5.1% of the participants are classifiable as probable disordered gamblers. The bias of the gambling type to pachinko and pachislot was unique to gamblers in Japan. Of the students sampled, 342 self-reported gambling symptoms via the South Oaks Gambling Screen. Hierarchical multivariate regression analysis indicated that one domain of gambling cognitive distortions was associated significantly with gambling symptoms among the 342 symptomatic participants: gambling expectancy (β = 0.19, p < .05). The multivariate model explained 47% of the variance in the gambling symptoms. Conclusion: This study successfully contributed to the sparse research on university student gambling in Japan. Specifically, our results indicated a statistically significant relationship between gambling cognitive distortions and gambling disorder symptoms. These results can inform the development of preventive education and treatment for university students with gambling disorder in Japan. The report also describes needs for future research of university students with gambling disorder

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD.

Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previously showed that EDEM2 stably disulfide-bonded to the thioredoxin domain-containing protein TXNDC11 is responsible for the first step (George et al., 2020). Here, we show that EDEM3 and EDEM1 are responsible for the second step. Incubation of pyridylamine-labeled M8B with purified EDEM3 alone produced M7 (M7A and M7C), M6, and M5. EDEM1 showed a similar tendency, although much lower amounts of M6 and M5 were produced. Thus, EDEM3 is a major α1,2-mannosidase for the second step from M8B. Both EDEM3 and EDEM1 trimmed M8B from a glycoprotein efficiently. Our confirmation of the Golgi localization of MAN1B indicates that no other α1,2-mannosidase is required for gpERAD. Accordingly, we have established the entire route of oligosaccharide processing and the enzymes responsible