Evidence-based bioethics: delineating the connections between science, practice, and values in medicine.

<p><b>A.</b> Secretion of FABP5 from adipose-derived stem cells (ADSC) after adipocyte differentiation at Day 0, Day 4 and Day 8 (n = 4 in each). Values were normalized to total protein concentration of the cell lysate. *P < 0.05 vs. Day 0. <b>B.</b> Flowchart of microarray analysis in ADSC treated with 1 μM recombinant FABP5 for 24 h. <b>C.</b> Gene ontology (GO) enrichment analysis. Significantly (Z-score > 0, P < 0.05) upregulated and downregulated GO terms of three GO categories, including cellular component, molecular function and biological process, were picked up and listed by a sort of lower P-value in each category. The abscissa of the bar plot was the number of annotated genes within the GO category. <b>D.</b> Cascade of the protein-protein interaction (PPI) network using a transcription factor binding site search data.</p

Antiatherosclerotic phenotype of perivascular adipose tissue surrounding the saphenous vein in coronary artery bypass grafting

冠動脈バイパス術（CABG）で大伏在静脈（SV）グラフトの血管周囲脂肪組織（PVAT）を温存したまま使用するNo-touch法が良好な成績を収め注目されている．本研究では術中に各種PVATを採取して組織性状と遺伝子発現を比較検討した．SV-PVATは冠動脈や大動脈のPVATに比してM1マクロファージの浸潤や炎症性サイトカイン発現が低く，No-touch法の成績向上に寄与している可能性が示唆された