2,846 research outputs found
Is depression a real risk factor for acute myocardial infarction mortality? A retrospective cohort study
Background: Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities. This study investigated whether continuative use of antidepressants (ADs), considered as a proxy of a state of depression, prior to acute myocardial infarction (AMI) is associated with a higher mortality afterwards. The outcome to assess was mortality by AD use. Methods: A retrospective cohort study was conducted in the Veneto Region on hospital discharge records with a primary diagnosis of AMI in 2002-2015. Subsequent deaths were ascertained from mortality records. Drug purchases were used to identify AD users. A descriptive analysis was conducted on patients' demographics and clinical data. Survival after discharge was assessed with a Kaplan-Meier survival analysis and Cox's multiple regression model. Results: Among 3985 hospital discharge records considered, 349 (8.8%) patients were classified as AD users'. The mean AMI-related hospitalization rate was 164.8/100,000 population/year, and declined significantly from 204.9 in 2002 to 130.0 in 2015, but only for AD users (-40.4%). The mean overall follow-up was 4.64.1years. Overall, 523 patients (13.1%) died within 30days of their AMI. The remainder survived a mean 5.3 +/- 4.0years. After adjusting for potential confounders, use of antidepressants was independently associated with mortality (adj OR=1.75, 95% CI: 1.40-2.19). Conclusions: Our findings show that AD users hospitalized for AMI have a worse prognosis in terms of mortality. The use of routinely-available records can prove an efficient way to monitor trends in the state of health of specific subpopulations, enabling the early identification of AMI survivors with a history of antidepressant use
PolĂticas pĂşblicas na agroindĂşstria do dendĂŞ na visĂŁo do produtor.
bitstream/item/63648/1/Oriental-Doc222.PD
Small-molecule modulators of mitochondrial channels as chemotherapeutic agents
Ion channels residing in the inner (IMM) and outer (OMM) mitochondrial membranes are emerging as noteworthy pharmacological targets in oncology. While these aspects have not been investigated for all of them, a role in cancer growth and/or metastasis and/or drug resistance has been shown at least for the IMM-residing Ca2+ uniporter complex and K+- selective mtKV1.3, mtIKCa, mtSKCa and mtTASK-3, and for the OMM Voltage-Dependent Anion Channel (mitochondrial porin). A special case is that of the Mitochondrial Permeability Transition Pore, a large pore which forms in the IMM of severely stressed cells, and which may be exploited to precipitate the death of cancerous cells. Here we briefly discuss the oncological relevance of mitochondria and their channels, and summarize the methods that can be adopted to selectively target these intracellular organelles. We then present an updated list of known mitochondrial channels, and review the pharmacology of those with proven relevance for cancer
Disentangling protostellar evolutionary stages in clustered environments using Spitzer-IRS spectra and comprehensive SED modeling
When studying the evolutionary stages of protostars that form in clusters,
the role of any intracluster medium cannot be neglected. High foreground
extinction can lead to situations where young stellar objects (YSOs) appear to
be in earlier evolutionary stages than they actually are, particularly when
using simple criteria like spectral indices. To address this issue, we have
assembled detailed SED characterizations of a sample of 56 Spitzer-identified
candidate YSOs in the clusters NGC 2264 and IC 348. For these, we use spectra
obtained with the Infrared Spectrograph onboard the Spitzer Space Telescope and
ancillary multi-wavelength photometry. The primary aim is twofold: 1) to
discuss the role of spectral features, particularly those due to ices and
silicates, in determining a YSO's evolutionary stage, and 2) to perform
comprehensive modeling of spectral energy distributions (SEDs) enhanced by the
IRS data. The SEDs consist of ancillary optical-to-submillimeter
multi-wavelength data as well as an accurate description of the 9.7 micron
silicate feature and of the mid-infrared continuum derived from line-free parts
of the IRS spectra. We find that using this approach, we can distinguish
genuine protostars in the cluster from T Tauri stars masquerading as protostars
due to external foreground extinction. Our results underline the importance of
photometric data in the far-infrared/submillimeter wavelength range, at
sufficiently high angular resolution to more accurately classify cluster
members. Such observations are becoming possible now with the advent of the
Herschel Space Observatory.Comment: Accepted for publication in Ap
Produção de alface hidropônica: um estudo de viabilidade técnico-economica.
Neste trabalho foi desenvolvido um projeto completo para a produção mensal de 30.000 plantas de alface em casa de vegetação, atravĂ©s da tĂ©cnica de hidroponia NFT. Elaborou-se tambĂ©m a análise econĂ´mica do projeto contemplando os investimentos necessários e seus custos operacionais. Os resultados demonstram que esta tĂ©cnica apresenta um bom potencial de viabilidade econĂ´mica, com lucro lĂquido da ordem de R 5.100,00/mĂŞs) e capacidade de amortização do investimento total (R$ 62.607,18) em aproximadamente 13 meses.CD-ROM 0
On the nature of the deeply embedded protostar OMC-2 FIR 4
We use mid-infrared to submillimeter data from the Spitzer, Herschel, and
APEX telescopes to study the bright sub-mm source OMC-2 FIR 4. We find a point
source at 8, 24, and 70 m, and a compact, but extended source at 160, 350,
and 870 m. The peak of the emission from 8 to 70 m, attributed to the
protostar associated with FIR 4, is displaced relative to the peak of the
extended emission; the latter represents the large molecular core the protostar
is embedded within. We determine that the protostar has a bolometric luminosity
of 37 Lsun, although including more extended emission surrounding the point
source raises this value to 86 Lsun. Radiative transfer models of the
protostellar system fit the observed SED well and yield a total luminosity of
most likely less than 100 Lsun. Our models suggest that the bolometric
luminosity of the protostar could be just 12-14 Lsun, while the luminosity of
the colder (~ 20 K) extended core could be around 100 Lsun, with a mass of
about 27 Msun. Our derived luminosities for the protostar OMC-2 FIR 4 are in
direct contradiction with previous claims of a total luminosity of 1000 Lsun
(Crimier et al 2009). Furthermore, we find evidence from far-infrared molecular
spectra (Kama et al. 2013, Manoj et al. 2013) and 3.6 cm emission (Reipurth et
al 1999) that FIR 4 drives an outflow. The final stellar mass the protostar
will ultimately achieve is uncertain due to its association with the large
reservoir of mass found in the cold core.Comment: Accpeted by ApJ, 17 pages, 11 figure
Phase Transition Study of Superconducting Microstructures
The presented results are part of a feasibility study of superheated
superconducting microstructure detectors. The microstructures (dots) were
fabricated using thin film patterning techniques with diameters ranging from
m up to m and thickness of m. We used arrays and single
dots to study the dynamics of the superheating and supercooling phase
transitions in a magnetic field parallel to the dot surface. The phase transi-
tions were produced by either varying the applied magnetic field strength at a
constant temperature or changing the bath temperature at a constant field.
Preliminary results on the dynamics of the phase transitions of arrays and
single indium dots will be reported.Comment: 7pages in LaTex format, five figures available upon request by
[email protected], preprint Bu-He 93/
Dangling bond energetics in carbon nitride and phosphorus carbide thin films with fullerene-like and amorphous structure
Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
Mixed endocrine-exocrine tumors of the gut are a heterogeneous group of neoplasms with uncertain histogenesis showing different morphologic and clinical features. The aim of this work is to clarify the histogenesis of these tumors by studying the genetic profile of both the endocrine and exocrine components. We performed an allelotyping analysis of five mixed endocrine-exocrine tumors (two gastric and three colonic) and one rectal collision tumor, using 35 polymorphic microsatellite markers covering a total of six chromosomes, including 3, 5q, 6, 11, 17, and 18. The loss of heterozygosity (LOH) analysis showed concurrent losses of the same allele in both the endocrine and exocrine components in all of the five mixed tumors composed by a poorly differentiated endocrine carcinoma or a well differentiated endocrine carcinoma associated with adenocarcinoma or adenoma. Among these tumors an identical LOH pattern was frequently found on chromosomes 17p, 18q, and 5q. Additional allelic losses restricted to the poorly differentiated endocrine carcinoma were often observed. On the contrary, in the only collision tumor composed by a well differentiated endocrine carcinoma associated with adenocarcinoma, completely different allelotypes between the two components were detected. These findings confirm a close genetic relationship between the two distinct histologic components within mixed endocrine-exocrine tumors, supporting the hypothesis that a monoclonal mechanism of tumorigenesis is the most frequent genetic event in mixed exocrine-endocrine tumors. The clonal divergence observed in the only collision tumor, composed by a well differentiated endocrine carcinoma associated with an adenocarcinoma, confirms the existence of double tumors growing next to each other coincidentally but showing different histogenesis and different tumorigenetic pathway
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