Soft Expansion of Double-Real-Virtual Corrections to Higgs Production at N3^3LO

We present methods to compute higher orders in the threshold expansion for the one-loop production of a Higgs boson in association with two partons at hadron colliders. This process contributes to the N$^3$LO Higgs production cross section beyond the soft-virtual approximation. We use reverse unitarity to expand the phase-space integrals in the small kinematic parameters and to reduce the coefficients of the expansion to a small set of master integrals. We describe two methods for the calculation of the master integrals. The first was introduced for the calculation of the soft triple-real radiation relevant to N$^3$LO Higgs production. The second uses a particular factorization of the three body phase-space measure and the knowledge of the scaling properties of the integral itself. Our result is presented as a Laurent expansion in the dimensional regulator, although some of the master integrals are computed to all orders in this parameter.Comment: 30 page

Probing stellar accretion with mid-infrared hydrogen lines

In this paper we investigate the origin of the mid-infrared (IR) hydrogen recombination lines for a sample of 114 disks in different evolutionary stages (full, transitional and debris disks) collected from the {\it Spitzer} archive. We focus on the two brighter {H~{\sc i}} lines observed in the {\it Spitzer} spectra, the {H~{\sc i}}(7-6) at 12.37$\mu$m and the {H~{\sc i}}(9-7) at 11.32$\mu$m. We detect the {H~{\sc i}}(7-6) line in 46 objects, and the {H~{\sc i}}(9-7) in 11. We compare these lines with the other most common gas line detected in {\it Spitzer} spectra, the {[Ne~{\sc iii}]} at 12.81$\mu$m. We argue that it is unlikely that the {H~{\sc i}} emission originates from the photoevaporating upper surface layers of the disk, as has been found for the {[Ne~{\sc iii}]} lines toward low-accreting stars. Using the {H~{\sc i}}(9-7)/{H~{\sc i}}(7-6) line ratios we find these gas lines are likely probing gas with hydrogen column densities of 10$^{10}$-10$^{11}$~cm$^{-3}$. The subsample of objects surrounded by full and transitional disks show a positive correlation between the accretion luminosity and the {H~{\sc i}} line luminosity. These two results suggest that the observed mid-IR {H~{\sc i}} lines trace gas accreting onto the star in the same way as other hydrogen recombination lines at shorter wavelengths. A pure chromospheric origin of these lines can be excluded for the vast majority of full and transitional disks.We report for the first time the detection of the {H~{\sc i}}(7-6) line in eight young (< 20~Myr) debris disks. A pure chromospheric origin cannot be ruled out in these objects. If the {H~{\sc i}}(7-6) line traces accretion in these older systems, as in the case of full and transitional disks, the strength of the emission implies accretion rates lower than 10$^{-10}$M$_{\odot}$/yr. We discuss some advantages of extending accretion indicators to longer wavelengths

Higgs production cross-section in a Standard Model with four generations at the LHC

We present theoretical predictions for the Higgs boson production cross-section via gluon fusion at the LHC in a Standard Model with four generations. We include QCD corrections through NLO retaining the full dependence on the quark masses, and the NNLO corrections in the heavy quark effective theory approximation. We also include electroweak corrections through three loops. Electroweak and bottom-quark contributions are suppressed in comparison to the Standard Model with three generations.Comment: 6 pages, 2 Tables, to appear in the proceedings of the XLVIth Rencontres de Moriond session devoted to Electroweak Interactions and Unified Theorie

Acid sphingomyelinase activity triggers microparticle release from glial cells

We have earlier shown that microglia, the immune cells of the CNS, release microparticles from cell plasma membrane after ATP stimulation. These vesicles contain and release IL-1β, a crucial cytokine in CNS inflammatory events. In this study, we show that microparticles are also released by astrocytes and we get insights into the mechanism of their shedding. We show that, on activation of the ATP receptor P2X7, microparticle shedding is associated with rapid activation of acid sphingomyelinase, which moves to plasma membrane outer leaflet. ATP-induced shedding and IL-1β release are markedly reduced by the inhibition of acid sphingomyelinase, and completely blocked in glial cultures from acid sphingomyelinase knockout mice. We also show that p38 MAPK cascade is relevant for the whole process, as specific kinase inhibitors strongly reduce acid sphingomyelinase activation, microparticle shedding and IL-1β release. Our results represent the first demonstration that activation of acid sphingomyelinase is necessary and sufficient for microparticle release from glial cells and define key molecular effectors of microparticle formation and IL-1β release, thus, opening new strategies for the treatment of neuroinflammatory diseases

Individual Health Budgets in Mental Health: Results of Its Implementation in the Friuli Venezia Giulia Region, Italy

Background: Individual Health Budget (IHB) is an intervention for recovery in mental health services, providing personalized care for subjects with severe disorders and complex needs. Little is known on its effectiveness and on the criteria for its delivery. Methods: A total of 67 IHB beneficiaries and 61 comparators were recruited among service users of the Mental Health Department of the Trieste Healthcare Agency, Italy. Data included sociodemographic and clinical variables, type of IHB, and Health of the Nation Outcome Scale (HoNOS) scores. Results: A comparison between groups showed significant differences in several socioeconomic and clinical characteristics. Multivariate logistic regression showed that IHB was positively associated to the 20-49 age group, single status, unemployment, low family support, cohabitation with relatives or friends, diagnosis of personality disorder, and a higher number of hospitalizations. The IHB group was at a higher risk of severe problems related to aggressive or agitated behaviors (OR = 1.4), hallucinations and delusions (OR = 1.5), and impairment in everyday life activities (OR = 2.1). Conclusions: IHB was used in patients with severe clinical and social problems. More resources, however, may be aimed at the working and social axes. More research is needed to better assess clinical and social outcomes of IHB and to adjust their intensity in a longitudinal perspective in order to enhance cost-effectivenes