THE CONCEALED SIDE OF THE HISTORY OF COMBINATORIAL CHEMISTRY

Combinatorial chemistry today is an accepted new branch of science that comprises methods widely applied in drug research and other research fields within chemistry and even outside of it. Its beginnings were slow and painful in the 1980s. The present account describes a story that has not been heretofore revealed in the history of its discovery. Its format is a conversation in which Árpád Furka, the original discoverer, provides the answers to István Hargittai´s questions

Changes of red blood cell aggregation parameters in a long-term follow-up of splenectomy, spleen-autotransplantation and partial or subtotal spleen resections in a canine model

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A Debreceni Egyetem Sebészeti Műtéttani Tanszékének története (1951–2017)

History of the Department of Operative Techniques and Surgial Research, Faculty of Medicine of the University of Debrecen. The Authors describe the establishment of the four Institutes of Surgical Anatomy and Operative Techniques in the 1951/1952 academic year in the Hungarian Medical Faculties. Then they introduce the 3 eras of the Institute in Debrecen: I. 1951-1986. (directed by Dénes Nagy from 1951 till 1953 and György Bornemisza from 1953 till 1986), II. 1986-2000 (directed by István Furka), III. 2000-2013 (directed by Irén Mikó). During that time the Institute had different names:  1. 1951-1972: Institute of Surgical Anatomy and Operative Techniques, 2. 1972-2000: Institute of Experimental Surgery, 3. 2000-2004: Institute of Operative Techniques and Surgical Research, 4. 2004-   Department of Operative Techniques and Surgical Research. The Authors review the wide spectrum of the educational and research work during the past (almost) 60 years. The Reader can have insight into the development of the Department, the accession of territory, the work of the Microsurgical- and Laparoscopic Educational and Training Centers and can get acquinted with the museums of the Department established by Prof. István Furka and Prof. Iren Mikó: Museum of Surgical Suture Materials, Exhibition of Surgical Staplers’ History, Sun Lee Microsurgical Museum, Memorial Place for Janos Veres (inventor of the Veres-needle that is used for laparoscopic interventions worldwide)

Ischaemiás-reperfusiós károsodások funkcionális és strukturális változásainak kivédése különböző (máj, vékonybél, szabad lebeny, amputatum) experimentalis sebészi modelleken = Protection of functional and structural changes of ischemia-reperfusion injuries on different experimental surgical models (liver, small bowel, free flap, limb)

A kutatás fő célkitűzései különböző szerveken végzett sebészi beavatkozások során az érleszorítások ischaemia-reperfusió (I/R) okozta károsodásainak vizsgálata volt megfelelő protektív módszerek kidolgozásához az esetleges klinikai szövődmények felismeréséhez nyolc kísérleti modellben. Főbb eredményeink: 1. Felhívtuk a figyelmet máj, vékonybél, musculus latissimus dorsi lebeny, amputatum és arterio-venosus (A-V) shunt modellekben arra, hogy a lokális és szisztémás keringés haemorheologiai paramétereinek -vvs deformálhatóság és vvs aggregatio- változásai az I/R károsodások korai jelzői lehetnek, melyeket szövettani, immunhisztokémiai és rutin kémiai vizsgálatok eredményei is alátámasztottak. 2. Máj modellnél megerősítettük a Báron manőver -a lig. hepatoduodenale leszorítás- jogosultságát, az egy vagy kétszeri alkalmazásának preventív hatását, mivel a további leszorítások a korai postoperatív szövődmények kockázatát növelik. 3. Az A-V shunt modell eredmények a haemodialysisre kerülő betegek hosszabb ideig biztosítható ""nyitva tartásához"", a kezelés folytatásához adtak biztató adatokat. 4. A musculus latissimus dorsi lebeny eredményei a szabadlebeny átültetések biztonságát növelheti a korai postoperatív időszakban, a plasztikai/rekonstrukciós sebészetben. | The main objectives of the research were in eight experimental models to investigate the ischemia-reperfusion (I/R) injuries due to vascular clamping during surgical interventions on various organs in order to develop proper protecting methods for recognizing the possible clinical complications. Our main findings are the followings: 1. We attracted attention in liver, small bowel, latissimus dorsi muscle (LDM) flap, amputate and arterio-venosus (A-V) shunt models that the changes of the systemic and local hemorheological parameters -RBC deformability and RBC aggregation- can be the early signs of I/R injuries, which was also supported by histological, immunohistochemical and routine chemical test results. 2. In case of the liver model the utility of the Báron’s manoeuvre -clamping of the hepatoduodenal ligament- was strengthened, with its preventive effect as applied one or two times, since further clamping periods raise the risk of early postoperative complications. 3. The results of the A-V shunt model supplied reassuring data for the management of longer lifetime shunts and for the treatment continuance in patients undergoing hemodialysis. 4. The results of the LDM flap model can increase the safety of free-flap transplantations in the early postoperative period in the plastic/reconstructive surgery

How does practice improve the skills of medical students during consecutive training courses?

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