An Algebraic Roadmap of Particle Theories, Part II: Theoretical checkpoints

An optimal algebraic model of particle physics has a number of checkpoints to pass. As a minimum, models should $\langle 1 \rangle$ conform to the Coleman-Mandula theorem (or establish a loophole), $\langle 2 \rangle$ evade familiar fermion doubling problems, $\langle 3 \rangle$ naturally explain the Standard Model's chirality, $\langle 4 \rangle$ exclude B-L gauge symmetry at low energy, and $\langle 5 \rangle$ explain the existence of three generations. We demonstrate how the model introduced in [1] passes checkpoints $\langle 1 \rangle, \langle 2 \rangle, \langle 3 \rangle, \langle 4 \rangle$, and has yet to cross $\langle 5 \rangle$. We close by elucidating an unexpected appearance of spacetime symmetries.Comment: 6 pages, 1 figure, Second paper in a series. Follows arXiv:2312.1237

An Algebraic Roadmap of Particle Theories, Part I: General construction

It is a curious fact that our most well-studied BSM theories can inform us about the Standard Model itself. Just over a decade ago, [1], Baez and Huerta explained how the Standard Model's gauge group can be seen to coincide with the intersection of Georgi and Glashow's SU(5), and Pati and Salam's $SU(4)\times SU(2)\times SU(2)$, inside Spin(10). More recently, [2], [3], it was shown how (up to a factor of B-L) the Spin(10) model, the Pati-Salam model, the Left-Right Symmetric model, the Standard Model pre-Higgs mechanism, and the Standard Model post-Higgs mechanism are interlinked via a sequence of division algebraic reflections. Between these three papers, [1], [2], [3], are six theories that have been studied extensively by particle physicists. In this article, we demonstrate how the full set of six familiar particle models may be laid out in one connected algebraic particle roadmap. The inclusion of a quaternionic reflection within the network further differentiates $W^{\pm}$ bosons from the $Z^0$ boson in comparison to the Standard Model. It may introduce subtle new considerations for the phenomenology of electroweak symmetry breaking.Comment: 14 pages, 6 figures, First paper in a serie

Wormhole throats in <i> R ^m </i> gravity

We consider wormhole geometries subject to a gravitational action consisting of non-linear powers of the Ricci scalar. Specifically, wormhole throats are studied in the case where Einstein gravity is supplemented with a Ricci-squared and inverse Ricci term. In this modified theory it is found that static wormhole throats respecting the weak energy condition can exist. The analysis is done locally in the vicinity of the throat, which eliminates certain restrictions on the models introduced by considering the global topology.Comment: 12 pages, 3 figures. Update includes more references and clarification that "zero tidal force" class of models are considered. Accepted for publication in Classical and Quantum Gravit

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression.

BACKGROUND: Ketamine as an antidepressant improves anhedonia as early as 2h post-infusion. These drug effects are thought to be exerted via actions on reward-related brain areas-yet, these actions remain largely unknown. Our study investigates ketamine's effects during the anticipation and receipt of an expected reward, after the psychotomimetic effects of ketamine have passed, when early antidepressant effects are reported. METHODS: We examined ketamine's effects during the anticipation and receipt of expected rewards on pre-defined brain areas, namely the dorsal and ventral striatum, the ventral tegmental area, the amygdala and the insula. We have recruited 37 male and female participants who remitted from depression and were free from symptoms and antidepressant treatments at the time of the scan. Participants were scanned, 2h after drug administration, in a double-blind cross over design (ketamine:0.5mg/kg and placebo) while performing a monetary reward task. RESULTS: A significant main effect of ketamine, across all ROIs, was observed during the anticipation and feedback phases of win and no-win trials. The drug effects were particularly prominent in the nucleus accumbens and putamen, which showed increased activation upon the receipt of smaller rewards compared to neutral. The levels of (2R,6R)-HNK, 2h post-infusion, significantly correlated with the activation observed in the ventral tegmental area for that contrast. CONCLUSIONS: These findings demonstrate that ketamine can produce detectable changes in reward-related brain areas, 2h after infusion, which occur without symptom changes and support the idea that ketamine might improve reward-related symptoms via modulation of response to feedback

Comparison and validation of 2 analytical methods for the determination of free fatty acids in dairy products by gas chromatography with flame ionization detection

peer-reviewedAccurate quantification of free fatty acids (FFA) in dairy products is important for quality control, nutritional, antimicrobial, authenticity, legislative, and flavor purposes. In this study, the performance of 2 widely used gas chromatographic flame ionization detection methods for determination of FFA in dairy products differing in lipid content and degree of lipolysis were evaluated. We used a direct on-column approach where the isolated FFA extract was injected directly and a derivatization approach where the FFA were esterified in the injector to methyl esters using tetramethylammonium hydroxide as a catalyst. A comprehensive validation was undertaken to establish method linearity, limits of detection, limits of quantification, accuracy, and precision. Linear calibrations of 3 to 700mg/L (R2>0.999) and 20 to 700mg/L (R2>0.997), and limits of detection and limits of quantification of 0.7 and 3mg/L and 5 and 20mg/L were obtained for the direct injection on-column and the derivatization method, respectively. Intraday precision of 1.5 to 7.2% was obtained for both methods. The direct injection on-column method had the lower levels of limits of detection and quantification, because FFA are directly injected onto the GC as opposed to the split injection used in the derivatization method. However, the direct injection on-column method experienced accumulative column phase deterioration and irreversible FFA absorption because of the acidic nature of the injection extract, which adversely affected method robustness and the quantification of some longer chain FFA. The derivatization method experienced issues with quantification of butyric acid at low concentrations because of coelution with the injection solvent peak, loss of polyunsaturated FFA due to degradation by tetramethylammonium hydroxide, and the periodic emergence of by-product peaks of the tetramethylammonium hydroxide reaction that interfered with the quantification of some short-chain FFA. The derivatization method is more robust, and because the derivatization step can be automated, it is more suitable for routine analysis of FFA in dairy products. However, considerable scope exists to develop an alternative gas chromatography with flame ionization detection method to quantify FFA in dairy products without any limitations that is robust and accurate

Lagrangian perspective on the origins of Denmark Strait Overflow

Author Posting. © American Meteorological Society, 2020. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 50(8), (2020): 2393-2414, doi:10.1175/JPO-D-19-0210.1.The Denmark Strait Overflow (DSO) is an important contributor to the lower limb of the Atlantic meridional overturning circulation (AMOC). Determining DSO formation and its pathways is not only important for local oceanography but also critical to estimating the state and variability of the AMOC. Despite prior attempts to understand the DSO sources, its upstream pathways and circulation remain uncertain due to short-term (3–5 days) variability. This makes it challenging to study the DSO from observations. Given this complexity, this study maps the upstream pathways and along-pathway changes in its water properties, using Lagrangian backtracking of the DSO sources in a realistic numerical ocean simulation. The Lagrangian pathways confirm that several branches contribute to the DSO from the north such as the East Greenland Current (EGC), the separated EGC (sEGC), and the North Icelandic Jet (NIJ). Moreover, the model results reveal additional pathways from south of Iceland, which supplied over 16% of the DSO annually and over 25% of the DSO during winter of 2008, when the NAO index was positive. The southern contribution is about 34% by the end of March. The southern pathways mark a more direct route from the near-surface subpolar North Atlantic to the North Atlantic Deep Water (NADW), and needs to be explored further, with in situ observations.This work was financially supported by the U.S. National Science Foundation under Grant Numbers OAC-1835640, OCE-1633124, OCE-1433448, and OCE-1259210

Notes on wormhole existence in scalar-tensor and F(R) gravity

Some recent papers have claimed the existence of static, spherically symmetric wormhole solutions to gravitational field equations in the absence of ghost (or phantom) degrees of freedom. We show that in some such cases the solutions in question are actually not of wormhole nature while in cases where a wormhole is obtained, the effective gravitational constant G_eff is negative in some region of space, i.e., the graviton becomes a ghost. In particular, it is confirmed that there are no vacuum wormhole solutions of the Brans-Dicke theory with zero potential and the coupling constant \omega > -3/2, except for the case \omega = 0; in the latter case, G_eff < 0 in the region beyond the throat. The same is true for wormhole solutions of F(R) gravity: special wormhole solutions are only possible if F(R) contains an extremum at which G_eff changes its sign.Comment: 7 two-column pages, no figures, to appear in Grav. Cosmol. A misprint corrected, references update

Observed deep cyclonic eddies around Southern Greenland

Recent mooring measurements from the Overturning in the Subpolar North Atlantic Program have revealed abundant cyclonic eddies at both sides of Cape Farewell, the southern tip of Greenland. In this study, we present further observational evidence, from both Eulerian and Lagrangian perspectives, of deep cyclonic eddies with intense rotation (ζ/f > 1) around southern Greenland and into the Labrador Sea. Most of the observed cyclones exhibit strongest rotation below the surface at 700–1000 dbar, where maximum azimuthal velocities are ~30 cm s−1 at radii of ~10 km, with rotational periods of 2–3 days. The cyclonic rotation can extend to the deep overflow water layer (below 1800 dbar), albeit with weaker azimuthal velocities (~10 cm s−1) and longer rotational periods of about one week. Within the middepth rotation cores, the cyclones are in near solid-body rotation and have the potential to trap and transport water. The first high-resolution hydrographic transect across such a cyclone indicates that it is characterized by a local (both vertically and horizontally) potential vorticity maximum in its middepth core and cold, fresh anomalies in the deep overflow water layer, suggesting its source as the Denmark Strait outflow. Additionally, the propagation and evolution of the cyclonic eddies are illustrated with deep Lagrangian floats, including their detachments from the boundary currents to the basin interior. Taken together, the combined Eulerian and Lagrangian observations have provided new insights on the boundary current variability and boundary–interior exchange over a geographically large scale near southern Greenland, calling for further investigations on the (sub)mesoscale dynamics in the region

Psoriasis prediction from genome-wide SNP profiles

<p>Abstract</p> <p>Background</p> <p>With the availability of large-scale genome-wide association study (GWAS) data, choosing an optimal set of SNPs for disease susceptibility prediction is a challenging task. This study aimed to use single nucleotide polymorphisms (SNPs) to predict psoriasis from searching GWAS data.</p> <p>Methods</p> <p>Totally we had 2,798 samples and 451,724 SNPs. Process for searching a set of SNPs to predict susceptibility for psoriasis consisted of two steps. The first one was to search top 1,000 SNPs with high accuracy for prediction of psoriasis from GWAS dataset. The second one was to search for an optimal SNP subset for predicting psoriasis. The sequential information bottleneck (sIB) method was compared with classical linear discriminant analysis(LDA) for classification performance.</p> <p>Results</p> <p>The best test harmonic mean of sensitivity and specificity for predicting psoriasis by sIB was 0.674(95% CI: 0.650-0.698), while only 0.520(95% CI: 0.472-0.524) was reported for predicting disease by LDA. Our results indicate that the new classifier sIB performs better than LDA in the study.</p> <p>Conclusions</p> <p>The fact that a small set of SNPs can predict disease status with average accuracy of 68% makes it possible to use SNP data for psoriasis prediction.</p

CompaGB: An open framework for genome browsers comparison

<p>Abstract</p> <p>Background</p> <p>Tools to visualize and explore genomes hold a central place in genomics and the diversity of genome browsers has increased dramatically over the last few years. It often turns out to be a daunting task to compare and choose a well-adapted genome browser, as multidisciplinary knowledge is required to carry out this task and the number of tools, functionalities and features are overwhelming.</p> <p>Findings</p> <p>To assist in this task, we propose a community-based framework based on two cornerstones: (i) the implementation of industry promoted software qualification method (QSOS) adapted for genome browser evaluations, and (ii) a web resource providing numerous facilities either for visualizing comparisons or performing new evaluations. We formulated 60 criteria specifically for genome browsers, and incorporated another 65 directly from QSOS's generic section. Those criteria aim to answer versatile needs, ranging from a biologist whose interest primarily lies into user-friendly and informative functionalities, a bioinformatician who wants to integrate the genome browser into a wider framework, or a computer scientist who might choose a software according to more technical features. We developed a dedicated web application to enrich the existing QSOS functionalities (weighting of criteria, user profile) with features of interest to a community-based framework: easy management of evolving data, user comments...</p> <p>Conclusions</p> <p>The framework is available at <url>http://genome.jouy.inra.fr/CompaGB</url>. It is open to anyone who wishes to participate in the evaluations. It helps the scientific community to (1) choose a genome browser that would better fit their particular project, (2) visualize features comparatively with easily accessible formats, such as tables or radar plots and (3) perform their own evaluation against the defined criteria. To illustrate the CompaGB functionalities, we have evaluated seven genome browsers according to the implemented methodology. A summary of the features of the compared genome browsers is presented and discussed.</p