14 research outputs found
PCN79 IMPACT OF NON-ADHERENCE TO IMATINIB ON PROGRESSION-FREE SURVIVAL AS 1ST TREATMENT FOR CHRONIC MYELOID LEUKEMIA IN BRAZIL: TWO YEARS FOLLOW UP
237: Long term results of allogeneic stem cell transplant for CML in pediatric patients A study of 50 cases transplanted over 20 years in a single institution
Guideline on myeloproliferative neoplasms: Associacão Brasileira de Hematologia, Hemoterapia e Terapia Cellular: Project guidelines: Associação Médica Brasileira – 2019
sem informação411173sem informaçãosem informaçã
Guidelines For The Diagnosis, Classification, Prophylaxis And Treatment Of Chronic Graft-versus-host Disease [diretrizes Para O Diagnóstico, Classificação, Profilaxia E Tratamento Da Doença Enxerto Contra Hospedeiro Crônica]
The lack of widely-used standardized diagnostic criteria may impair both the true evaluation of chronic graft-versus-host disease and the correlation of its severity with transplant-related mortality. At the I Consensus of the Brazilian Society of Bone Marrow Transplantation - SBTMO that took place in June 2009, the Group of GVHD Studies Brazil-Seattle (GEDECH), presented the guidelines for diagnosis, classification, prophylaxis and treatment of chronic GVHD as proposed by the National Institutes of Health and based on the reality in Brazilian Centers. These proposals, including standardization of features used in diagnosis and tools to score involved organs and to assess the overall severity, should be used in clinical studies of chronic graft-versus-host disease. These criteria are useful to better analyze the incidence of this disease, in addition to evaluate the extension of the involvement of organs or the site affected and its influence on late transplantation mortality. Prophylaxis and treatment proposed for this important complication of hematopoietic stem cell transplantations were discussed and graded according to the levels of evidence established by the National Institutes of Health.32SUPPL. 12239Shulman, H.M., Sullivan, K.M., Weiden, P.L., Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients (1980) Am J Med, 69 (2), pp. 204-217Wingard, J.R., Piantadosi, S., Vogelsang, G.B., Predictors of death from chronic graft-versus-host disease after bone marrow transplantation (1989) Blood, 74 (4), pp. 1428-1435Sullivan, K.M., Witherspoon, R.P., Storb, R., Prednisone and azathioprine compared with prednisone and placebo for treatment of chronic graft-v-host disease: Prognostic influence of prolonged thrombocytopenia after allogeneic marrow transplantation (1988) Blood, 72 (2), pp. 546-554Lee, S.J., Klein, J.P., Barrett, A.J., Severity of chronic graft-versus-host disease: Association with treatment-related mortality and relapse (2002) Blood, 100 (2), pp. 406-414Akpek, G., Lee, S.J., Flowers, M.E., Performance of a new clinical grading system for chronic graft-versus-host disease: A multicenter study (2003) Blood, 102 (3), pp. 802-809Arora, M., Burns, L.J., Davies, S.M., Chronic graft-versus-host disease: A prospective cohort study (2003) Biol Blood Marrow Transplant, 9 (1), pp. 38-45Stewart, B.L., Storer, B., Storek, J., Duration of immunosuppressive treatment for chronic graft-versus-host disease (2004) Blood, 104 (12), pp. 3501-3506Filipovich, A.H., Weisdorf, D., Pavletic, S., National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report (2005) Biol Blood Marrow Transplant, 11 (12), pp. 945-956Martin, P.J., Weisdorf, D., Przepiorka, D., Hirschfeld, S., Farrell, A., Rizzo, J.D., Design of Clinical Trials Working Group National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report (2006) Biol Blood Marrow Transplant, 12 (5), pp. 491-505Pavletic, S.Z., Martin, P., Lee, S.J., Mitchell, S., Jacobsohn, D., Cowen, E.W., Response criteria working group. Measuring therapeutic response in chronic graft-versus-host disease: National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. response criteria working group report (2006) Biol Blood Marrow Transplant, 12 (3), pp. 252-566Couriel, D., Carpenter, P.A., Cutler, C., Bolanos-Meade, J., Treister, N.S., Gea-Banacloche, J., Ancillary therapy and supportive care of chronic graft-versus-host disease: National institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report (2006) Biol Blood Marrow Transplant, 12 (4), pp. 375-396Shulman, H.M., Kleiner, D., Lee, S.J., Morton, T., Pavletic, S.Z., Farmer, E., Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host D. Disease: II. Pathology Working Group Report (2006) Biol Blood Marrow Transplant, 12 (1), pp. 31-47Schultz, K.R., Miklos, D.B., Fowler, C.K., Shizuru, J., Zorn, E., Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report (2006) Biol Blood Marrow Transplant, 12 (2), pp. 126-137Blume, K.G., Beutler, E., Bross, K.J., Bone-marrow ablation and allogeneic marrow transplantation in acute leukemia (1980) N Engl J Med, 302 (19), pp. 1041-1046Kansu, E., Gooley, T., Flowers, M.E.D., Administration of cyclosporine for 24 months compared with 6 months for prevention of chronic graft-versus-host disease: A prospective randomized clinical trial[brief report] (2001) Blood, 98, pp. 3868-3870Chao, N.J., Parker, P.M., Niland, J.C., Paradoxical effect of thalidomide prophylaxis on chronic graft-vs-host disease (1996) Biol Blood Marrow Transplant, 2 (2), pp. 86-92Cutler, C., Li, S., Ho, V.T., Koreth, J., Alyea, E., Soiffer, R.J., Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation (2007) Blood, 109 (7), pp. 3108-3114Bacigalupo, A., Lamparelli, T., Bruzzi, P., Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO) (2001) Blood, 98 (10), pp. 2942-2947Deeg, H.J., Storer, B.E., Boeckh, M., Reduced incidence of acute and chronic graft-versus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen (2006) Biol Blood Marrow Transplant, 12 (5), pp. 573-584Bacigalupo, A., Lamparelli, T., Barisione, G., Bruzzi, P., Guidi, S., Alessandrino, P.E., Thymoglobulin prevents chronic graft-versus-host disease,chronic lung dysfunction, and late transplant-related mortality: Long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation (2006) Biol Blood Marrow Transplant, 12 (5), pp. 560-565Soiffer, R.J., Martin, P., T-cell depletion of allogeneic hematopoietic stem cell grafts (2004) Clinical Bone Marrow and Blood Stem Cell Transplantation, pp. 416-425. , Atkinson K, Champlin R, Ritz J et al (eds.), 3 rd ed. Cambridge, UK: Cambridge University PressKottaridis, P.D., Milligan, D.W., Chopra, R., In vivo: Campath-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation (2000) Blood, 96 (7), pp. 2419-2425Arora, M., Therapy of chronic graft-versus-host disease (2008) Best Prac & Res Clin Haematol, 21 (2), pp. 271-279Koc, S., Leisenring, W., Flowers, M.E., Anasetti, C., Deeg, H.J., Nash, R.A., Therapy for chronic graft-versus-host disease: A randomized trial comparing cyclosporine plus prednisone versus prednisone alone (2002) Blood, 100 (1), pp. 48-51Lee, S.J., Flowers, M.E., Recognizing and managing chronic graft-versus-host disease (2008) Hematology Am Soc Hematol Educ Program, pp. 134-141Martin, P.J., Carpenter, P.A., Sanders, J.E., Flowers, M.E., Diagnosis and clinical management of chronic graft-versus-host disease (2004) Int J Hematol, 79 (3), pp. 221-228Arora, M., Nagaraj, S., Wagner, J.E., Barker, J.N., Brunstein, C.G., Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): Higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB) (2007) Biol Blood Marrow Transplant, 13 (10), pp. 1145-1152Martin, P.J., Storer, B.E., Rowley, S.D., Evaluation of mycophenolate mofetil for initial treatment of chronic graft-versus-host disease (2009) Blood, 13 (21), pp. 5074-5082Wang, Y., Xu, L.P., Liu, D.H., First-line therapy for chronic graft-versus-host disease that includes low-dose methotrexate is associated with a high response rate (2009) Biol Blood Marrow Transplant, 15 (4), pp. 505-511Koc, S., Leisenring, W., Flowers, M.E., Anasetti, C., Deeg, H.J., Nash, R.A., Thalidomide for treatment of patients with chronic graft-versus-host disease (2000) Blood, 96 (12), pp. 3995-3996Arora, M., Wagner, J.E., Davies, S.M., Randomized clinical trial of thalidomide, cyclosporine and prednisone versus cyclosporine and prednisone as initial therapy for chronic graft-versus-host disease (2001) Biol Blood Marrow Transplant, 7 (5), pp. 265-273Bergeron, A., Belle, A., Chevret, S., Combined inhaled steroids and bronchodilatators in obstructive airway disease after allogeneic stem cell transplantation (2007) Bone Marrow Transplant, 39 (9), pp. 547-553Bashoura, L., Gupta, S., Jain, A., Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation (2008) Bone Marrow Transplant, 41 (1), pp. 63-67Lopez, F., Parker, P., Nademanee, A., Efficacy of mycophenolate mofetil in the treatment of chronic graft-versus-host disease (2005) Biol Blood Marrow Transplant, 11 (4), pp. 307-313Baudard, M., Vicent, A., Moreau, P., Mycophenolate mofetil for the treatment of acute and chronic GVHD is effective and well tolerated but induces a high risk of infectious complications: A series of 21 BM or PBSC transplant patients (2002) Bone Marrow Transplant, 30, pp. 287-295Mookerjee, B., Altomonte, V., Vogelsang, G., Salvage therapy for refractory chronic graft-versus-host disease with mycophenolate mofetil and tacrolimus (1999) Bone Marrow Transplant, 24, pp. 517-520Busca, A., Locatelli, F., Marmont, F., Audisio, E., Falda, M., Response to mycophenolate mofetil therapy in refractory chronic graft-versus-host disease (2003) Haematologica, 88, pp. 837-839Flowers, M.E., Apperley, J.F., Besien, K., A multicenter prospective phase II randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease (2008) Blood, 112 (7), pp. 2667-2674Couriel, D.R., Hosing, C., Saliba, R., Extracorporeal photo-chemotherapy for the treatment of steroid-resistant chronic GVHD (2006) Blood, 107, pp. 3074-3080Apisarnthanarax, N., Donato, M., Korbling, M., Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation: Feasibility and results (2003) Bone Marrow Transplant, 31 (6), pp. 459-465Foss, F.M., Divenuti, G.M., Chin, K., Prospective study of extracorporeal photopheresis in steroid-refractory or steroid-resistant extensive chronic graft-versus-host disease: Analysis of response and survival incorporating prognostic factors (2005) Bone Marrow Transplant, 35 (12), pp. 1187-1193Carnevale-Schianca, F., Martin, P., Sullivan, K., Flowers, M., Gooley, T., Anasetti, C., Changing from cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease (2000) Biol Blood Marrow Transplant, 6 (6), pp. 613-620Tzakis, A.G., Abu-Elmagd, K., Fung, J.J., Bloom, E.J., Nour, B., Greif, F., FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation (1991) Transplant Proc, 23 (6), pp. 3225-3227Couriel, D.R., Saliba, R., Escalon, M.P., Hsu, Y., Ghosh, S., Ippoliti, C., Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease (2005) Br J Haematol, 130 (3), pp. 409-417Johnston, L.J., Brown, J., Shizuru, J.A., Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease (2005) Biol Blood Marrow Transplant, 11 (1), pp. 47-55Jurado, M., Vallejo, C., Perez-Simon, J.A., Sirolimus as part of immunosuppressive therapy for refractory chronic graft-versus-host disease (2007) Biol Blood Marrow Transplant, 13 (6), pp. 701-706Cutler, C., Miklos, D., Kim, H.T., Rituximab for steroid-refractory chronic graft-versus-host disease (2006) Blood, 108, pp. 756-762Zaja, F., Bacigalupo, A., Patriarca, F., Treatment of refractory chronic GVHD with rituximab: A GITMO study (2007) Bone Marrow Transplant, 40, pp. 273-277Jacobsohn, D.A., Chen, A.R., Zahurak, M., Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease (2007) J Clin Oncol, 25, pp. 4255-4261Kulkarni, S., Powles, R., Sirohi, B., Thalidomide after allogeneic haematopoietic stem cell transplantation: Activity in chronic but not in acute graft-versus-host disease (2003) Bone Marrow Transplant, 32, pp. 165-170Browne, P.V., Weisdorf, D.J., Defor, T., Response to thalidomide therapy in refractory chronic graft-versus-host disease (2000) Bone Marrow Transplant, 26, pp. 865-869Parker, P.M., Chao, N., Nademanee, A., Thalidomide as salvage therapy for chronic graft-versus-host disease (1995) Blood, 86, pp. 3604-3609Hockenbery, D.M., Cruickshank, S., Rodell, T.C., A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease (2007) Blood, 109 (10), pp. 4557-4563Iyer, R.V., Hahn, T., Roy, H.N., Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease (2005) Biol Blood Marrow Transplant, 11 (8), pp. 587-592Giaccone, L., Martin, P., Carpenter, P., Safety and potential efficacy of low-dose methotrexate for treatment of chronic graft-versus-host disease (2005) Bone Marrow Transplant, 36, pp. 337-341Inagaki, J., Nagatoshi, Y., Hatano, M., Low-dose MTX for the treatment of acute and chronic graft-versus-host disease in children (2008) Bone Marrow Transplant, 41 (6), pp. 571-577Akpek, G., Lee, S.M., Anders, V., Vogelsang, G.B., A high-dose pulse steroid regimen for controlling active chronic graftversus-host disease (2001) Biol Blood Marrow Transplant, 7, pp. 495-502Gilman, A.L., Chan, K.W., Mogul, A., Hydroxychloroquine for the treatment of chronic graft-versus-host disease (2000) Biol Blood Marrow Transplant, 6 (3 A), pp. 327-334Willenbacher, W., Basara, N., Blau, I.W., Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab (2001) Br J Haematol, 112 (3), pp. 820-823Chiang, K.Y., Abhyankar, S., Bridges, K., Recombinant human tumor necrosis factor receptor fusion protein as complementary treatment for chronic graft-versus-host disease (2002) Transplantation, 73, pp. 665-667Magro, L., Catteau, B., Coiteux, V., Efficacy of imatinib mesylate in the treatment of refractory sclerodermatous chronic GVHD (2008) Bone Marrow Transplant, 42 (11), pp. 757-760Shapira, M.Y., Abdul-Hai, A., Resnick, I.B., Alefacept treatment for refractory chronic extensive GVHD (2009) Bone Marrow Transplant, 43 (4), pp. 339-343Jacobsohn, D.A., Emerging therapies for graft-versus-host disease (2003) Expert Opin Emerg Drugs, 8 (2), pp. 323-338Mayer, J., Krejci, M., Doubek, M., Pulse cyclophosphamide for corticosteroid-refractory graft-versus-host disease (2005) Bone Marrow Transplant, 35 (7), pp. 699-705Lee, S.J., Wegner, S.A., McGarigle, C.J., Treatment of chronic graft-versus-host disease with clofazimine (1997) Blood, 89 (7), pp. 2298-2302Marcellus, D.C., Altomonte, V.L., Farmer, E.R., Etretinate therapy for refractory sclerodermatous chronic graft-versus-host disease (1999) Blood, 93 (1), pp. 66-70Andree, H., Hilgendorf, I., Leithaeuser, M., Junghanss, C., Holzhueter, S., Loddenkemper, C., Steiner, B., Wolff, D., Enteral budesonide in treatment for mils and moderate gastrointestinal chronic GVHD (2008) Bone Marrow Transplant, 42 (8), pp. 541-546Hori, A., Kanda, Y., Goyama, S., Onishi, Y., A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease (2005) Transplantation, 79 (3), pp. 372-374Ringden, O., Uzunel, M., Rasmusson, I., Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease (2006) Transplantation, 81 (10), pp. 1390-1397Lee, S.J., New approaches for preventing and treating chronic graft-versus-host disease (2005) Blood, 105 (11), pp. 4200-4206Shlomchik, W.D., Lee, S.J., Couriel, D., Pavletic, S.D., Transplantation's greatest challenges: Advances in chronic graft-versus-host disease (2007) Biol Blood Marrow Transplant, 13 (SUPPL. 1), pp. 2-10Berger, M., Biasin, E., Saglio, F., Fagioli, F., Innovative approaches to treat steroid-resistant or steroid refractory GVHD (2008) Bone Marrow Transplant, 42 (SUPPL. 2), pp. S101-S105Kitajima, T., Imamura, S., Graft-versus-host reaction enhanced by ultraviolet radiation (1993) Arch Dermatol Res, 285 (8), pp. 499-501Grundmann-Kollmann, M., Martin, H., Ludwig, R., Klein, S., Boehncke, W.H., Hoelzer, D., Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease (2002) Transplantation, 74 (11), pp. 1631-1634Vogelsang, G.B., Wolff, D., Altomonte, V., Treatment of chronic graft-versus-host disease with ultraviolet irradiation and psoralen (PUVA) (1996) Bone Marrow Transplant, 17 (6), pp. 1061-1067Bouzas, L.F., Doença enxerto-contra-hospedeiro crônica em trans-plante de medula óssea:Tratamento com psoraleno e ultravioleta A. Dissertaçáo (Mestrado em Hematologia) (1996) Faculdade De Medici-na, Universidade Federal Do Rio De Janeiro, , Rio de JaneiroBouzas, L.F.S., Ferman, S., Matta, J.L.R., Tabak, D.G., Diamond, M.H., Ornellas, M.S., Treatment of chronic graft versus host disease with 8-methoxypsoralen and ultravioleta (1993) Blood, 82 (SUPPL. 1), p. 420Elad, S., Or, R., Resnick, I., Shapira, M.Y., Topical tacrolimus-a novel treatment alternative for cutaneous chronic graft-versus-host disease (2003) Transpl Int, 16 (9), pp. 665-670Ziemer, M., Gruhn, B., Thiele, J.J., Elsner, P., Treatment of extensive chronic cutaneous graft-versus-host disease in an infant with topical pimecrolimus (2004) J Am Acad Dermatol, 50 (6), pp. 946-948Smith, A.P.S., Fife, C.E., Advanced therapeutics: The biochemistry and biophysical basis of wound products (2004) Wound Care Practice, pp. 685-730. , Sheffield PJ ed., Flagstaff AZ: Best Publishing CompanyCouriel, D.R., Ancillary and supportive care in chronic graft-versus-host disease (2008) Best Pract Res Clin Haematol, 21 (2), pp. 291-307Epstein, J.B., Gorsky, M., Epstein, M.S., Nantel, S., Topical azathioprine in the treatment of immune-mediated chronic oral inflammatory conditions: A series of cases (2001) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 91 (1), pp. 56-61Schubert, M.M., Correa, M.E., Oral graft-versus-host disease (2008) Dent Clin North Am, 52 (1), pp. 79-109+viii+ixAlbert, M.H., Becker, B., Schuster, F.R., Klein, B., Binder, V., Adam, K., Oral graft vs. host disease in children - treatment with topical tacrolimus ointment (2007) Pediatr Transplant, 11 (3), pp. 306-311Al-Hashimi, I., Schifter, M., Lockhart, P.B., Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations (2007) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103 (SUPPL.), pp. S25+e21-12Horwitz, M.E., Sullivan, K.M., Chronic graft-versus-host disease (2006) Blood Rev, 20 (1), pp. 15-27Eckardt, A., Starke, O., Stadler, M., Reuter, C., Hertenstein, B., Severe oral chronic graft-versus-host disease following allogeneic bone marrow transplantation: Highly effective treatment with topical tacrolimus (2004) Oral Oncol, 40 (8), pp. 811-814Wolff, D., Anders, V., Corio, R., Oral PUVA and topical steroids for treatment of oral manifestations of chronic graft-vs.-host disease (2004) Photodermatol Photoimmunol Photomed, 20 (4), pp. 184-190Sanchez, A.R., Sheridan, P.J., Rogers, R.S., Successful treatment of oral lichen planus-like chronic graft-versus-host disease with topical tacrolimus: A case report (2004) J Periodontol, 75 (4), pp. 613-619Elad, S., Or, R., Resnick, I., Shapira, M.Y., Topical tacrolimus - A novel treatment alternative for cutaneous chronic graft-versus-host disease (2003) Transpl Int, 16 (9), pp. 665-670Epstein, J.B., Nantel, S., Sheoltch, S.M., Topical azathioprine in the combined treatment of chronic oral graft-versus-host disease (2000) Bone Marrow Transplant, 25 (6), pp. 683-687Epstein, J.B., Truelove, E.L., Topical cyclosporine in a bioadhesive for treatment of oral lichenoid mucosal reactions: An open label clinical trial (1996) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 82 (5), pp. 532-536Bertz, H., Afting, M., Kreisel, W., Duffner, U., Greinwald, R., Finke, J., Feasibility and response to budesonide as topical corticosteroid therapy for acute intestinal GVHD (1999) Bone Marrow Transplant, 24 (11), pp. 1185-1189Schubert, M.M., Sullivan, K.M., Recognition, incidence, and management of oral graft-versus-host disease (1990) NCI Monogr, pp. 135-143Calissendorff, B., el Azazi, M., Lönnqvist, B., Dry eye syndrome in long-term follow-up of bone marrow transplanted patients (1989) Bone Marrow Transplant, 4 (6), pp. 675-678Jack, M.K., Jack, G.M., Sale, G.E., Shulman, H.M., Sullivan, K.M., Ocular manifestations of graft-v-host disease (1983) Arch Ophthalmol, 101 (7), pp. 1080-1084Hill, J.C., Slow-release artificial tear inserts in the treatment of dry eyes in patients with rheumatoid arthritis (1989) Br J Ophthalmol, 73 (2), pp. 151-154Peral, A., Dominguez-Godinez, C.O., Carracedo, G., Pintor, J., Therapeutic targets in dry eye syndrome (2008) Drug News Perspect, 21 (3), pp. 166-176. , ReviewCosar, C.B., Cohen, E.J., Rapuano, C.J., Maus, M., Penne, R.P., Flanagan, J.C., Laibson, P.R., Tarsorrhaphy: Clinical experience from a cornea practice (2001) Cornea, 20 (8), pp. 787-791American Academy of Ophthalmology (1997) Ophthalmology, 104 (9), pp. 1521-1524. , Punctal occlusion for the dry eye. Three-year revisionMarsh, P., Pflugfe