A novel method to construct taxonomy electrical appliances based on load signatures

A load signature is an electrical expression that a load device or appliance distinctly possesses. Load signatures can be applied to produce many useful services and products, such as, determining the energy usage of individual appliances, monitoring the health of critical equipment, monitoring power quality, and developing facility management tools. Load signatures of typical yet extensive loads are needed to be collected before applying them to different services and products. As there are an enormous number of electrical appliances, it is beneficial to classify the appliances for building a well-organized load signature database. The objective of this study is to develop an effective method to classify the loads. A 2-dimensional form of load signatures, voltage-current (V-I) trajectory, is suggested for characterizing the typical household appliances. Hierarchical clustering method was employed to classify the appliances and construct the taxonomy of the appliances. The taxonomy based on V-I trajectory was compared to the taxonomies based on traditional power metrics and eigenvectors in the previous studies. It was found that the groups of appliances in the taxonomy based on V-I trajectory were well-separated and had engineering meanings. © 2007 IEEE.published_or_final_versio

How can BIM support construction safety management? Development of SIM

BIM is continuously changing the way construction can be approached, from design, scheduling, costing to facilities management. However, even though construction safety is a worldwide issue, and though previous, yet limited, studies have proven its great potential, BIM has not been extended to include automated construction safety management functions, i.e., hazard identification, assessment and control for construction works. In fact, as many as 71% of safety incidents can be prevented by safety considerations at design stage. Automation via BIM is the key to enhance effectiveness and efficiency of safety management, but development of Safety Information Modelling (SIM) is the key pre-requisite. This paper aims to outline a research project for developing both information and technical requirements for SIM via questionnaire survey, focus group, and real case studies. The project results, to be validated by real projects, will act as solid platform for developing:- i) Practical guidance to construction and safety professionals on the types of safety management a SIM can conduct, and the ways of utilizing the safety information in a SIM model [based on the systematic SIM information requirements (e.g., object identification, geometry attributes, safety rules)]; and ii) Overall guidance to software developers to develop appropriate SIM tools for different scenarios [based on the systematic SIM technical requirements (e.g., model information exchange, visualization, conflict analysis process for risk assessment, reliability)].published_or_final_versio

One-way optical tunneling induced by nonreciprocal dispersion of Tamm states in magnetophotonic crystals

2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Best practices to prevent transmission and control outbreaks of hand, foot, and mouth disease in childcare facilities: a systematic review.

INTRODUCTION: Hand, foot, and mouth disease continues to cause seasonal epidemics in the Asia-Pacific Region. Since the current Enterovirus 71 vaccines do not provide cross-protection for all Enterovirus species that cause hand, foot, and mouth disease, there is an urgent need to identify appropriate detection tools and best practice to prevent its transmission and to effectively control its outbreaks. This systematic review aimed to identify characteristics of outbreak and assess the impact and effectiveness of detection tools and public health preventive measures to interrupt transmission. The findings will be used to recommend policy on the most effective responses and interventions in Hong Kong to effectively minimise and contain the spread of the disease within childcare facilities. METHODS: We searched the following databases for primary studies written in Chinese or English: MEDLINE, EMBASE, Global Health, WHO Western Pacific Region Index Medicus database, China National Knowledge Infrastructure Databases, and Chinese Scientific Journals Database. Studies conducted during or retrospective to outbreaks of hand, foot, and mouth disease caused by Enterovirus 71 from 1980 to 2012 within childcare facilities and with a study population of 0 to 6 years old were included. RESULTS: Sixteen studies conducted on outbreaks in China showed that hand, foot, and mouth disease spread rapidly within the facility, with an outbreak length of 4 to 46 days, especially in those with delayed notification (after 24 hours) of clustered outbreak (with five or more cases discovered within the facility) to the local Center for Disease Control and Prevention and delayed implementation of a control response. The number of classes affected ranged from 1 to 13, and the attack rate for children ranged from 0.97% to 28.18%. CONCLUSIONS: Communication between key stakeholders about outbreak confirmation, risk assessment, and surveillance should be improved. Effective communication facilitates timely notification (within 24 hours) of clustered outbreaks to a local Center for Disease Control and Prevention. Timely implementation of a control response is effective in minimising incidence and length of an outbreak in childcare facilities. The government should provide incentives for childcare facilities to train infection control specialists who can serve as the first contact, knowledge, and communication points, as well as facilitate exchange of information and provision of support across stakeholders during a communicable disease epidemic

Development of a Bonner Sphere neutron spectrometer from a commercial neutron dosimeter

Bonner Spheres have been used widely for the measurement of neutron spectra with neutron energies ranged from thermal up to at least 20 MeV . A Bonner Sphere neutron spectrometer (BSS) was developed by extending a Berthold LB 6411 neutron-dose-rate meter. The BSS consists of a 3He thermal-neutron detector with integrated electronics, a set of eight polyethylene spherical shells and two optional lead shells of various sizes. The response matrix of the BSS was calculated with GEANT4 Monte Carlo simulation. The BSS had a calibration uncertainty of ± 8.6% and a detector background rate of (1.57 ± 0.04) × 10−3 s−1. A spectral unfolding code NSUGA was developed. The NSUGA code utilizes genetic algorithms and has been shown to perform well in the absence of a priori information.postprin

Genome maps across 26 human populations reveal population-specific patterns of structural variation.

Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in one experiment. Analyzing optical genome maps of 154 individuals from the 26 populations sequenced in the 1000 Genomes Project, we find that phylogenetic population patterns of large SVs are similar to those of single nucleotide variations in 86% of the human genome, while ~2% of the genome has high structural complexity. We are able to characterize SVs in many intractable regions of the genome, including segmental duplications and subtelomeric, pericentromeric, and acrocentric areas. In addition, we discover ~60 Mb of non-redundant genome content missing in the reference genome sequence assembly. Our results highlight the need for a comprehensive set of alternate haplotypes from different populations to represent SV patterns in the genome

A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures

BACKGROUND: Highly parallel analysis of gene expression has recently been used to identify gene sets or 'signatures' to improve patient diagnosis and risk stratification. Once a signature is generated, traditional statistical testing is used to evaluate its prognostic performance. However, due to the dimensionality of microarrays, this can lead to false interpretation of these signatures. PRINCIPAL FINDINGS: A method was developed to test batches of a user-specified number of randomly chosen signatures in patient microarray datasets. The percentage of random generated signatures yielding prognostic value was assessed using ROC analysis by calculating the area under the curve (AUC) in six public available cancer patient microarray datasets. We found that a signature consisting of randomly selected genes has an average 10% chance of reaching significance when assessed in a single dataset, but can range from 1% to ∼40% depending on the dataset in question. Increasing the number of validation datasets markedly reduces this number. CONCLUSIONS: We have shown that the use of an arbitrary cut-off value for evaluation of signature significance is not suitable for this type of research, but should be defined for each dataset separately. Our method can be used to establish and evaluate signature performance of any derived gene signature in a dataset by comparing its performance to thousands of randomly generated signatures. It will be of most interest for cases where few data are available and testing in multiple datasets is limited

Notch signaling during human T cell development

Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse

Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function

<p>Abstract</p> <p>Background</p> <p>Previous studies demonstrated <it>Ganoderma lucidum </it>polysaccharides (GL-PS), a form of bioactive β-glucan can stimulate the maturation of monocyte-derived dendritic cells (DC). The question of how leukemic cells especially in monocytic lineage respond to GL-PS stimuli remains unclear.</p> <p>Results</p> <p>In this study, we used <it>in vitro</it> culture model with leukemic monocytic cell-lines THP-1 and U937 as monocytic effectors cells for proliferation responses and DCs induction. We treated the THP-1 and U937 cells with purified GL-PS (100 μg/mL) or GL-PS with GM-CSF/IL-4. GL-PS alone induced proliferative response on both THP-1 and U937 cells but only THP-1 transformed into typical DC morphology when stimulated with GL-PS plus GM-CSF/IL-4. The transformed THP-1 DCs had significant increase expression of HLA-DR, CD40, CD80 and CD86 though not as high as the extent of normal monocyte-derived DCs. They had similar antigen-uptake ability as the normal monocyte-derived DCs positive control. However, their potency in inducing allogeneic T cell proliferation was also less than that of normal monocyte-derived DCs.</p> <p>Conclusion</p> <p>Our findings suggested that GL-PS could induce selected monocytic leukemic cell differentiation into DCs with immuno-stimulatory function. The possible clinical impact of using this commonly used medicinal mushroom in patients with monocytic leukemia (AML-M4 and M5) deserved further investigation.</p