Adherencia farmacológica en hipertensos crónicos de 25 a 59 años, según test de Martín-Bayarre-Grau, Unidad de Salud de Dulce Nombre de María, Chalatenango, período junio septiembre, 2022.

En este trabajo de investigación de tipo descriptivo, corte transversal, se abordó el nivel de adherencia de pacientes entre los 25 - 59 años con diagnóstico de hipertensión arterial que consultan en la Unidad de Salud Especializada de Dulce Nombre de María, a través del test de Martín Bayarre Grau, utilizando una muestra de 230 pacientes elegidos al azar mediante un muestreo aleatorio simple, siendo un total de 73% de mujeres y 27% de hombres, obteniéndose un 63% de pacientes con adherencia parcial. De igual manera se estudiaron 4 ámbitos que se ven inmersos en esta; determinándose en cuanto a las pautas terapéuticas, que los indicadores más deficientes fueron los relacionados a estilos de vid

Implementation of Stewardship Programs in Hospitals: Systematic Review

Background: Antimicrobial resistance is a pandemic issue affecting hospital patients. There are many studies showing what can be done to decrease resistance of many microbes, but there is not one complete method. This review indicates the effective methods that can be used to prevent resistance from spreading in hospitals.Methods: The review was set to focus on antimicrobial resistance, misuse, and overuse of antimicrobials, what doctors are doing that influences resistance and stewardship programs. Articles published from 2008- 2018 were found using Web of Science, ScienceDirect, and PLOS.Results: Out of the 15 articles found, 7 articles met the ideal selection criteria and were included in the review. All articles demonstrated the importance of antimicrobial resistance and provided ways in which resistance can be decreased. All studies reported the use of stewardship programs were necessary, but only three articles demonstrated its effectiveness.Conclusion: This review demonstrates a high need for antimicrobial stewardship programs to decrease the evolution of antimicrobial resistance. However, there is a problem with individual medical providers not complying to such programs due to the restrictions they say it creates. The results state otherwise and in fact demonstrate how a medical provider’s behavior must change to provide significance on the implementation of successful stewardship programs

Implementation of Stewardship Programs in Hospitals: Systematic Review

Background: Antimicrobial resistance is a pandemic issue affecting hospital patients. There are many studies showing what can be done to decrease resistance of many microbes, but there is not one complete method. This review indicates the effective methods that can be used to prevent resistance from spreading in hospitals.Methods: The review was set to focus on antimicrobial resistance, misuse, and overuse of antimicrobials, what doctors are doing that influences resistance and stewardship programs. Articles published from 2008- 2018 were found using Web of Science, ScienceDirect, and PLOS.Results: Out of the 15 articles found, 7 articles met the ideal selection criteria and were included in the review. All articles demonstrated the importance of antimicrobial resistance and provided ways in which resistance can be decreased. All studies reported the use of stewardship programs were necessary, but only three articles demonstrated its effectiveness.Conclusion: This review demonstrates a high need for antimicrobial stewardship programs to decrease the evolution of antimicrobial resistance. However, there is a problem with individual medical providers not complying to such programs due to the restrictions they say it creates. The results state otherwise and in fact demonstrate how a medical provider’s behavior must change to provide significance on the implementation of successful stewardship programs

Nivel de exposición a factores de riesgo psicosociales laborales de la salud en la empresa ENACAL León, marzo-noviembre de 2011

Tesis ( Lic. en Psicología)-Universidad Nacional Autónoma de Nicaragua, LeónUNAN-Leó

Adherencia Farmacológica en hipertensos crónicos de 25 a 59 años, según test de Martín-Bayarre-Grau, Unidad de Salud de Dulce Nombre de María, Chalatenango, período junio-septiembre, 2022

En este trabajo de investigación de tipo descriptivo, corte transversal, se abordó el nivel de adherencia de pacientes entre los 25 - 59 años con diagnóstico de hipertensión arterial que consultan en la Unidad de Salud Especializada de Dulce Nombre de María, a través del test de Martín Bayarre Grau, utilizando una muestra de 230 pacientes elegidos al azar mediante un muestreo aleatorio simple, siendo un total de 73% de mujeres y 27% de hombres, obteniéndose un 63% de pacientes con adherencia parcial. De igual manera se estudiaron 4 ámbitos que se ven inmersos en esta; determinándose en cuanto a las pautas terapéuticas, que los indicadores más deficientes fueron los relacionados a estilos de vida; sobre las dosis terapéuticas, se estableció que un 93% de la población estudiada las cumple sin mayor dificultad, mientras que los que la tuvieron mencionaron que las principales causas eran la polifarmacia o la automedicación; con respecto al conocimiento del tratamiento, los pacientes lograron cumplir su tratamiento sin esfuerzo o necesidad de apoyo de algún familiar, debido a que al saber sobre su tratamiento (nombre, dosificación, y posibles efectos secundarios) no requerían de estos; finalmente, en tanto a la implicación del paciente, existe una participación activa por parte del paciente en cuanto a la toma de decisiones y manifestación de aceptación de la toma de su tratamiento, sin embargo, siguen persistiendo ideas erróneas en cuanto a la prescripción, consecuencias de no tomarlo u otras dudas que bien pudieran solventarse durante la consulta al tener una relación médico-paciente ideal

Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy.

BACKGROUND & AIMS: The stroma in pancreatic ductal adenocarcinoma (PDAC) contributes to its immunosuppressive nature and therapeutic resistance. Herein we sought to modify signaling and enhance immunotherapy efficacy by targeting multiple stromal components through both intracellular and extracellular mechanisms. METHODS: A murine liver metastasis syngeneic model of PDAC was treated with focal adhesion kinase inhibitor (FAKi), anti-programmed cell death protein 1 (PD-1) antibody, and stromal hyaluronan (HA) degradation by PEGylated recombinant human hyaluronidase (PEGPH20) to assess immune and stromal modulating effects of these agents and their combinations. RESULTS: The results showed that HA degradation by PEGPH20 and reduction in phosphorylated FAK expression by FAKi leads to improved survival in PDAC-bearing mice treated with anti-PD-1 antibody. HA degradation in combination with FAKi and anti-PD-1 antibody increases T-cell infiltration and alters T-cell phenotype toward effector memory T cells. FAKi alters the expression of T-cell modulating cytokines and leads to changes in T-cell metabolism and increases in effector T-cell signatures. HA degradation in combination with anti-PD-1 antibody and FAKi treatments reduces granulocytes, including granulocytic- myeloid-derived suppressor cells and decreases C-X-C chemokine receptor type 4 (CXCR4)-expressing myeloid cells, particularly the CXCR4-expressing granulocytes. Anti-CXCR4 antibody combined with FAKi and anti-PD-1 antibody significantly decreases metastatic rates in the PDAC liver metastasis model. CONCLUSIONS: This represents the first preclinical study to identify synergistic effects of targeting both intracellular and extracellular components within the PDAC stroma and supports testing anti-CXCR4 antibody in combination with FAKi as a PDAC treatment strategy

A reference human induced pluripotent stem cell line for large-scale collaborative studies.

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned candidate human iPSC lines and deeply characterized their genetic properties using whole genome sequencing, their genomic stability upon CRISPR-Cas9-based gene editing, and their phenotypic properties including differentiation to commonly used cell types. These studies identified KOLF2.1J as an all-around well-performing iPSC line. We then shared KOLF2.1J with groups around the world who tested its performance in head-to-head comparisons with their own preferred iPSC lines across a diverse range of differentiation protocols and functional assays. On the strength of these findings, we have made KOLF2.1J and its gene-edited derivative clones readily accessible to promote the standardization required for large-scale collaborative science in the stem cell field.Chan Zuckerberg Initiative Neurodegeneration Challenge Network, New York Stem Cell Foundatio