Famous architectures in urban contexts: the impact of colours and materials

Architecture is not just a container or a place in which it is possible to perform functions; architecture is everything that surrounds us, it is the space in which we immerse ourselves and with which we communicate. It is not the shape of the project that first influences our perception of space, whether it is open or closed, but the colours and materials that characterise and define it, making it harmonious and pleasant or, in the opposite way, hostile and inhospitable. In 1981 the UNI 8289:1981 "Construction. Needs of the final user. Classification" defined the term "well-being" as "the set of conditions relating to states of the building system appropriate to life, to health, to the performance of the users' activities", how do colours and materials contribute to the conditions of well-being? Which are the targets that can be achieved through the wise use of these elements? The aim of this work is to analyse the application of colours and materials in famous architectures in order to determinate the impact at urban and human level, how they dialogue with the context and how they dialogue with human perceptions, identifying three directions of intervention: colour and materials as anthropomorphic relation, colours and materials as pictorial support, colour and materials as function

Interdisciplinary and International Workshop as Technological Design Method Focused on the European Ods Strategy

The innovative rules of the Europe 2020 Strategy, which follow the Lisbon Strategy (2000) and the Copenhagen Declaration (2002), promote smart and sustainable growth through the promotion of lowpollutant, resource-efficient and effective project strategies for improving human, social and environmental conditions. This paper illustrates the workshop design experience conducted in collaboration between the Escuela Superior de Edificacion (ETSEM) of the Universidad Politecnica de Madrid, the Department of Civil, Building and Environmental Engineering (DICEA) of Università di Napoli "Federico II" and the Department of Architecture and Industrial Design (DADI) of Università della Campania "L. Vanvitelli", focusing on the added value for the three research groups to integrate different teaching methods according that strategies

European overview of sustainable policies and approaches in COST C25 member countries

The implementation of the principles and methods towards a Sustainable Construction varies across different countries in Europe. In some countries, the sustainability of the construction sector has been effectively taken into consideration over the last years, while in other its implementation is at an initial stage. Many reasons may be pointed out for this situation. Different countries have different understandings of what is entailed in Sustainable Construction. Different cultural and educational backgrounds, along with different priorities in each country, are also contributing for the lack of a common European approach. General frameworks, aiming to cover every aspect of Sustainable Construction and to provide a consistent and integrated approach, such as Agenda 21 for Sustainable Construction, gave a major advance in the search for a common approach for the construction sector. However, general agreed methodologies and tools to make this common approach operational are still missing.European Science Foundation - COST Action C2

Association of TGFβ1, TNFα, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians

BACKGROUND: Cytokines play an important role in the development of diabetic chronic renal insufficiency (CRI). Transforming growth factor β1 (TGF β1) induces renal hypertrophy and fibrosis, and cytokines like tumor necrosis factor-alpha (TNFα), chemoattractant protein-1 (MCP-1), and regulated upon activation and normal T cell expressed and secreted (RANTES) mediate macrophage infiltration into kidney. Over expression of these chemokines leads to glomerulosclerosis and interstitial fibrosis. The effect of MCP-1 and RANTES on kidney is conferred by their receptors i.e., chemokine receptor (CCR)-2 and CCR-5 respectively. We tested association of nine single nucleotide polymorphisms (SNPs) from TGFβ1, TNFα, CCR2 and CCR5 genes among individuals with type-2 diabetes with and without renal insufficiency. METHODS: Type-2 diabetes subjects with chronic renal insufficiency (serum creatinine ≥ 3.0 mg/dl) constituted the cases, and matched individuals with diabetes of duration ≥ 10 years and normoalbuminuria were evaluated as controls from four centres in India. Allelic and genotypic contributions of nine SNPs from TGFβ1, TNFα, CCR2 and CCR5 genes to diabetic CRI were tested by computing odds ratio (OR) and 95% confidence intervals (CI). Sub-analysis of CRI cases diabetic retinopathy status as dependent variable and SNP genotypes as independent variable in a univariate logistic regression was also performed. RESULTS: SNPs Tyr81His and Thr263Ile in TGF β1 gene were monomorphic, and Arg25Pro in TGF β1 gene and Δ32 polymorphism in CCR5 gene were minor variants (minor allele frequency <0.05) and therefore were not considered for case-control analysis. A significant allelic association of 59029G>A SNP of CCR5 gene has been observed and the allele 59029A seems to confer predisposition to development of diabetic CRI (OR 1.39; CI 1.04–1.84). In CRI subjects a compound group of genotypes "GA and AA" of SNP G>A -800 was found to confer predisposition for proliferative retinopathy (OR 3.03; CI 1.08–8.50, p = 0.035). CONCLUSION: Of the various cytokine gene polymorphisms tested, allele 59029A of CCR5 gene is significantly associated with diabetic renal insufficiency among Asian Indians. Result obtained for 59029G>A SNP of CCR5 gene is in conformity with reports from a Japanese population but due to sub-optimal power of the sample, replication in larger sample set is warranted

Targeting HSP90 for cancer therapy

Heat-shock proteins (HSPs) are molecular chaperones that regulate protein folding to ensure correct conformation and translocation and to avoid protein aggregation. Heat-shock proteins are increased in many solid tumours and haematological malignancies. Many oncogenic proteins responsible for the transformation of cells to cancerous forms are client proteins of HSP90. Targeting HSP90 with chemical inhibitors would degrade these oncogenic proteins, and thus serve as useful anticancer agents. This review provides an overview of the HSP chaperone machinery and the structure and function of HSP90. We also highlight the key oncogenic proteins that are regulated by HSP90 and describe how inhibition of HSP90 could alter the activity of multiple signalling proteins, receptors and transcriptional factors implicated in carcinogenesis