Roses Have Thorns: Understanding the Downside of Oncological Care Delivery Through Visual Analytics and Sequential Rule Mining

Personalized head and neck cancer therapeutics have greatly improved survival rates for patients, but are often leading to understudied long-lasting symptoms which affect quality of life. Sequential rule mining (SRM) is a promising unsupervised machine learning method for predicting longitudinal patterns in temporal data which, however, can output many repetitive patterns that are difficult to interpret without the assistance of visual analytics. We present a data-driven, human-machine analysis visual system developed in collaboration with SRM model builders in cancer symptom research, which facilitates mechanistic knowledge discovery in large scale, multivariate cohort symptom data. Our system supports multivariate predictive modeling of post-treatment symptoms based on during-treatment symptoms. It supports this goal through an SRM, clustering, and aggregation back end, and a custom front end to help develop and tune the predictive models. The system also explains the resulting predictions in the context of therapeutic decisions typical in personalized care delivery. We evaluate the resulting models and system with an interdisciplinary group of modelers and head and neck oncology researchers. The results demonstrate that our system effectively supports clinical and symptom research

Correlates of illicit methadone use in New York City: A cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Despite growing concern about illicit methadone use in the US and other countries, there is little data about the prevalence and correlates of methadone use in large urban areas. We assessed the prevalence and examined correlates of lifetime and recent illicit methadone use in New York City (NYC).</p> <p>Methods</p> <p>1,415 heroin, crack, and cocaine users aged 15–40 years were recruited in NYC between 2000 and 2004 to complete interviewer-administered questionnaires.</p> <p>Results</p> <p>In multivariable logistic regression, non-injection drug users who used illicit methadone were more likely to be heroin dependent, less than daily methamphetamine users and to have a heroin using sex partner in the last two months. Injection drug users who used illicit methadone were more likely to use heroin daily, share injection paraphernalia and less likely to have been in a detoxification program and to have not used marijuana in the last six months.</p> <p>Conclusion</p> <p>The results overall suggest that illicit (or street) methadone use is likely not a primary drug of choice, but is instead more common in concert with other illicit drug use.</p

Sterile neutrinos and supernova nucleosynthesis

A light sterile neutrino species has been introduced to explain simultaneously the solar and atmospheric neutrino puzzles and the results of the LSND experiment, while providing for a hot component of dark matter. Employing this scheme of neutrino masses and mixings, we show how matter-enhanced active-sterile neutrino transformation followed by active-active neutrino transformation can solve robustly the neutron deficit problem encountered by models of r-process nucleosynthesis associated with neutrino-heated supernova ejecta.Comment: 29 pages, 3 postscript figures, submitted to Phys. Rev.

The Grizzly, March 27, 1981

Parents Day Slated for Early April • Overwhelming Enthusiasm Welcomes Special Olympics • Bomberger Tower Under Construction • SPC Elects New Grizzly Editor-in-Chief • Shakespeare Opens • Departmental Focus: Math Department • Transplanted Texan: NY to Collegeville • Spectrum Tries New Ticket Sales • Values Next Forum Topic • TV Production in Communications • Language Clubs Host Dessert Festival • Final Exam Schedule • Baseball Team Carries Much Potential • Hoopsters Finish 3rd in Nation • Tennis Team Prepares for Tough Season • Women\u27s Lacrosse Start Season 1-1https://digitalcommons.ursinus.edu/grizzlynews/1056/thumbnail.jp

A New Dark Matter Candidate: Non-thermal Sterile Neutrinos

We propose a new and unique dark matter candidate: $\sim 100$ eV to $\sim 10$ keV sterile neutrinos produced via lepton number-driven resonant MSW (Mikheyev-Smirnov-Wolfenstein) conversion of active neutrinos. The requisite lepton number asymmetries in any of the active neutrino flavors range from 10$^{-3}$ to 10$^{-1}$ of the photon number - well within primordial nucleosynthesis bounds. The unique feature here is that the adiabaticity condition of the resonance strongly favors the production of lower energy sterile neutrinos. The resulting non-thermal (cold) energy spectrum can cause these sterile neutrinos to revert to non-relativistic kinematics at an early epoch, so that free-streaming lengths at or below the dwarf galaxy scale are possible. Therefore, the main problem associated with light neutrino dark matter candidates can be circumvented in our model.Comment: Latex 11 pages + 1 figur

The Grizzly, March 20, 1981

Special Olympics at Ursinus This Weekend • IFC All Set for Dance • Basketball Team Shootin\u27 for National Title • St. Andrews Scholarship Applications Being Taken • McQuillan Warns of Student Loan Cuts • USGA Notes • Evening Student Awarded Phillips Prize • Departmental Focus: Economics / Business Administration • Texan in New York • Rush Clarifies Itself in Moving Pictures • Positive Rock Radio • Midsummer Night\u27s Dream in Final Preparation • UC Secretaries: Service Beyond the Call of Duty • Classics Club Announces Movie • Course Offerings 1981-1982 • Ursinus Basketball in Final Four • All-American Giff Earns Third • Gymnastics Season Seen as a Successhttps://digitalcommons.ursinus.edu/grizzlynews/1055/thumbnail.jp

Updating the Infection Risk Reduction Hierarchy: Preventing Transition into Injection

Current approaches to prevention of blood-borne infections in injection drug users include referral to drug abuse treatment, access to sterile syringes, bleach disinfection of injection equipment, and education about not sharing equipment. However, rates of some blood-borne infections (e.g., hepatitis C virus) remain elevated among injection drug users, especially early after initiation into injection drug use. With lower infection rates in noninjectors and transition into injection drug use occurring most commonly among these noninjectors, prevention of transition into injection drug use as an additional step to reduce risk for acquisition and transmission of blood-borne infections merits closer attention.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/40275/2/Vlahov_Updating the Infection Risk Reduction Hierarchy_2004.pd

Ecstasy Use Among Hispanic and Black Substance Users in New York City

Surveillance data suggests that use of ecstasy in the U.S. is predominantly among white adolescent and young adults. To investigate ecstasy use among substance users in New York City we added questions to ongoing efforts to recruit heroin and cocaine users. Of 715 participants recruited, 58.3% were injection dug users (IDUs). The median age was 32 (range 17–64), 76.4% were male, 49.0% were currently homeless, 62.4% were Hispanic, 27.3% were black, and 34.5% were born outside the United States. Overall, 23.4% used ecstasy in their lifetime and 11.9% had used in the last-6 months. In multivariate logistic regression, correlates of lifetime ecstasy use included younger age, being born in the U.S., and current homelessness. We observed a significant interaction between injection drug use and race where, compared to black non-IDUs, Hispanic non-IDUs, and white IDUs were significantly more likely to have a history of lifetime ecstasy use while black IDUs were significantly less likely. These findings are limited to persons who use other drugs, but suggest that further investigation of ecstasy use in minority populations is warranted.http://deepblue.lib.umich.edu/bitstream/2027.42/40374/2/Ompad_Ecstasy Use Among Hispanic and Black_2005.pd

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Infection of T cells by HIV-1 can occur through binding of virus to dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) on dendritic cells and transfer of virus to CD4(+) T cells. Here we show that a subset of B cells in the blood and tonsils of normal donors expressed DC-SIGN, and that this increased after stimulation in vitro with interleukin 4 and CD40 ligand, with enhanced expression of activation and co-stimulatory molecules CD23, CD58, CD80, and CD86, and CD22. The activated B cells captured and internalized X4 and R5 tropic strains of HIV-1, and mediated trans infection of T cells. Pretreatment of the B cells with anti–DC-SIGN monoclonal antibody blocked trans infection of T cells by both strains of HIV-1. These results indicate that DC-SIGN serves as a portal on B cells for HIV-1 infection of T cells in trans. Transmission of HIV-1 from B cells to T cells through this DC-SIGN pathway could be important in the pathogenesis of HIV-1 infection

CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4.

The mammalian Pcdhg gene cluster encodes a family of 22 cell adhesion molecules, the gamma-Protocadherins (γ-Pcdhs), critical for neuronal survival and neural circuit formation. The extent to which isoform diversity-a γ-Pcdh hallmark-is required for their functions remains unclear. We used a CRISPR/Cas9 approach to reduce isoform diversity, targeting each Pcdhg variable exon with pooled sgRNAs to generate an allelic series of 26 mouse lines with 1 to 21 isoforms disrupted via discrete indels at guide sites and/or larger deletions/rearrangements. Analysis of 5 mutant lines indicates that postnatal viability and neuronal survival do not require isoform diversity. Surprisingly, given reports that it might not independently engage in trans-interactions, we find that γC4, encoded by Pcdhgc4, is the only critical isoform. Because the human orthologue is the only PCDHG gene constrained in humans, our results indicate a conserved γC4 function that likely involves distinct molecular mechanisms