26 research outputs found
Dimensões nasofarÃngeas e sintomas respiratórios após a cirurgia de retalho farÃngeo em crianças e adultos
Lunar Phase-Dependent Expression of Cryptochrome and a Photoperiodic Mechanism for Lunar Phase-Recognition in a Reef Fish, Goldlined Spinefoot
Lunar cycle-associated physiology has been found in a wide variety of organisms. Recent study has revealed that mRNA levels of Cryptochrome (Cry), one of the circadian clock genes, were significantly higher on a full moon night than on a new moon night in coral, implying the involvement of a photoreception system in the lunar-synchronized spawning. To better establish the generalities surrounding such a mechanism and explore the underlying molecular mechanism, we focused on the relationship between lunar phase, Cry gene expression, and the spawning behavior in a lunar-synchronized spawner, the goldlined spinefoot (Siganus guttatus), and we identified two kinds of Cry genes in this animal. Their mRNA levels showed lunar cycle-dependent expression in the medial part of the brain (mesencephalon and diencephalon) peaking at the first quarter moon. Since this lunar phase coincided with the reproductive phase of the goldlined spinefoot, Cry gene expression was considered a state variable in the lunar phase recognition system. Based on the expression profiles of SgCrys together with the moonlight's pattern of timing and duration during its nightly lunar cycle, we have further speculated on a model of lunar phase recognition for reproductive control in the goldlined spinefoot, which integrates both moonlight and circadian signals in a manner similar to photoperiodic response
Comparação entre duas abordagens diferentes de tratamento cirúrgico da insuficiência velofarÃngea
Investigation of postoperative hypernasality after superiorly based posterior pharyngeal flap
Correlação entre fechamento velofarÃngeo e dimensões nasofarÃngeas após cirurgia de retalho farÃngeo avaliados por meio da técnica fluxo-pressão Correlation between velopharyngeal closure and nasopharyngeal dimensions after pharyngeal flap surgery assessed by pressure-flow technique
OBJETIVO: Verificar se a área dos orifÃcios velofarÃngeos obtida após o retalho farÃngeo (RF) durante a respiração de repouso (AVFr) é um indicador do grau de fechamento velofarÃngeo durante a fala (AVFf). MÉTODOS: Os sujeitos foram 62 pacientes com fissura de palato, associada ou não à fissura de lábio, de ambos os gêneros, com idades entre seis e 32 anos, submetidos ao RF há, pelo menos, 12 meses. AVFr e AVFf foram determinadas por meio da técnica fluxo-pressão. Valores de AVFr inferiores a 0,500 cm² foram considerados subnormais. A AVFf foi classificada como adequada (0-0,049 cm²), marginal (0,050-0,199 cm²) ou inadequada (>0,200 cm²). A associação entre os valores de AVFr e AVFf pós-cirúrgicos foi analisada por meio de um modelo de regressão logÃstica. RESULTADOS: Após o RF, 92% dos pacientes com valores de AVFr subnormais (<0,500 cm²) apresentaram fechamento velofarÃngeo adequado. A proporção de pacientes com valores de AVFr normais (>0,500 cm²) e fechamento velofarÃngeo adequado foi menor, porém ainda expressiva (55%). Não houve associação estatisticamente significante entre as duas variáveis. CONCLUSÃO: A maioria dos pacientes com retalho largo apresentou fechamento velofarÃngeo adequado durante a fala. Entretanto, os resultados mostraram que as dimensões dos orifÃcios velofarÃngeos durante a respiração de repouso não podem predizer a eficácia do retalho farÃngeo para a fala.<br>PURPOSE: To investigate whether postoperative velopharyngeal orifice area during nasal breathing at rest (VPAb) can predict velopharyngeal closure during speech (VPAs). METHODS: The subjects were 62 patients with cleft palate, associated or not with cleft lip, of both genders, with ages between six and 32 years, who underwent pharyngeal flap surgery (PFS) at least 12 months before the evaluation performed for this study. VPAb and VPAs were assessed using the pressure-flow technique. VPAb values below 0.500cm² were considered subnormal. VPAs was categorized as adequate (0-0.049cm²), borderline (0.050-0.199cm²) or inadequate (>0.200cm²). A logistic regression model analyzed the association between VPAb and VPAs. RESULTS: After PFS, 92% of the patients with subnormal VPAb values (<0.500cm²) presented adequate velopharyngeal closure. The percentage of patients with normal VPAb values (>0.500cm²) who also presented adequate closure was smaller, but still significant (55%). The association between VPAb and VPAs values was not statistically significant. CONCLUSION: Most patients with large flaps presented adequate velopharyngeal closure during speech. However, the findings show that the velopharyngeal orifice area during breathing is not a good predictor of the effectiveness of the pharyngeal flap for speech