147 research outputs found
A Case of Acute Superior Mesenteric Artery Embolism with Severe Ischemic Liver Injury Successfully Treated by Endovascular Treatment
We describe an interesting clinical course of a patient who developed severe ischemic liver injury due to acute embolism of the superior mesenteric artery (SMA) and celiac artery. A 70-year-old man was hospitalized for abdominal pain and diarrhea. Abdominal computed tomography demonstrated a variant
common hepatic artery arising from the SMA and multiple thromboembolic occlusions of visceral arteries, including the SMA and celiac artery. Laboratory data showed markedly elevated hepatic enzymes, which increased after admission despite the initiation of systemic anticoagulant and thrombolytic
therapy. The patient was successfully treated by endovascular recanalization of the SMA occlusion via transcatheter embolus aspiration, thrombolysis, balloon angioplasty, and stent placement.
Severe ischemic liver injury may occur in the setting of synchronous embolism of the SMA and celiac artery, and these phenomena may have a critical impact on the choice of treatment strategies and prognosis. Endovascular treatment appears to an effective treatment option
Spectropolarimetric Study on Circumstellar Structure of Microquasar LS I +61deg 303
We present optical linear spectropolarimetry of the microquasar LS I
+61 303. The continuum emission is mildly polarized (up to 1.3 %) and
shows almost no temporal change. We find a distinct change of polarization
across the H emission line, indicating the existence of polarization
component intrinsic to the microquasar. We estimate the interstellar
polarization (ISP) component from polarization of the H line and derive
the intrinsic polarization component. The wavelength dependence of the
intrinsic component is well explained by Thomson scattering in equatorial disk
of the Be-type mass donor. The position angle (PA) of the intrinsic
polarization represents the rotational axis of the Be disk.
This PA is nearly perpendicular to the PA of the radio jet found during
quiescent phases. Assuming an orthogonal disk-jet geometry around the compact
star, the rotational axis of the accretion disk is almost perpendicular to that
of the Be disk. Moreover, according to the orbital parameters of the
microquasar, the compact star is likely to get across the Be disk around their
periastron passage. We discuss the peculiar circumstellar structure of this
microquasar inferred from our observation and possible connection with its
high-energy activities.Comment: 17pages, 7figures; accepted for Publications of the Astronomical
Society of Japa
Anti-Tumor Effect in Human Lung Cancer by a Combination Treatment of Novel Histone Deacetylase Inhibitors: SL142 or SL325 and Retinoic Acids
Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer. In this study, we investigated the anti-tumor activity in lung cancer cells of the novel cyclic amide-bearing hydroxamic acid based HDAC inhibitors SL142 and SL325. In A549 and H441 lung cancer cells both SL142 and SL325 induced more cell growth inhibition and cell death than the hydroxamic acid-based HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Moreover, the combination treatment using retinoid drugs ATRA or 9-cis RA along with SL142 or SL325 significantly induced more apoptosis and suppressed colony formation than the single use of either. The expression of the retinoic acid receptors RARα, RARβ, RXRα and RXRβ were unchanged with the treatment. However a luciferase reporter construct (pGL4. RARE 7x) containing seven tandem repeats of the retinoic acid responsible element (RARE) generated significant transcriptional activity after the combination treatment of retinoic acids and SL142 or SL325 in H441 lung cancer cells. Moreover, apoptosis-promoting Bax expression and caspase-3 activity was increased after the combination treatment. These results suggest that the combination treatment of SL142 or SL325 with retinoic acids exerts significant anti-tumor activity and is a promising therapeutic candidate to treat human lung cancer
Suzaku observations of the Hydra A cluster out to the virial radius
We report Suzaku observations of the northern half of the Hydra A cluster out
to ~1.4 Mpc, reaching the virial radius. This is the first Suzaku observations
of a medium-size (kT ~3 keV) cluster out to the virial radius. Two observations
were conducted, north-west and north-east offsets, which continue in a filament
direction and a void direction of the large-scale structure of the Universe,
respectively. The X-ray emission and distribution of galaxies elongate in the
filament direction. The temperature profiles in the two directions are mostly
consistent with each other within the error bars and drop to 1.5 keV at 1.5
r_500. As observed by Suzaku in hot clusters, the entropy profile becomes
flatter beyond r_500, in disagreement with the r^1.1 relationship that is
expected from accretion shock heating models. When scaled with the average
intracluster medium (ICM) temperature, the entropy profiles of clusters
observed with Suzaku are universal and do not depend on system mass. The
hydrostatic mass values in the void and filament directions are in good
agreement, and the Navarro, Frenk, and White universal mass profile represents
the hydrostatic mass distribution up to ~ 2 r_500. Beyond r_500, the ratio of
gas mass to hydrostatic mass exceeds the result of the Wilkinson microwave
anisotropy probe, and at r_100, these ratios in the filament and void
directions reach 0.4 and 0.3, respectively. We discuss possible deviations from
hydrostatic equilibrium at cluster outskirts. We derived radial profiles of the
gasmass- to-light ratio and iron-mass-to-light ratio out to the virial radius.
Within r_500, the iron-mass-to-light ratio of the Hydra A cluster was compared
with those in other clusters observed with Suzaku.Comment: 16 pages, 15 figures; Accepted for publication in PAS
Obesity and Perioperative management – Review –
Obesity is a contributing factor to life-style related diseases such as diabetes, hypertension and dyslipidemia, as well as being a cause of metabolic syndromes. It has been predicted that more than half of the adult population in the world might be obese within the next twenty years. Once a person is diagnosed with metabolic syndrome, conditions such as diabetes, hypertension and dyslipidemia may remain mild even while visceral fat obesity slowly advances arterial sclerosis. Eventually, severe clinical conditions such as heart diseases and stroke can result. In recent years, there are more and more patients diagnosed with morbid obesity both inside and outside of Japan. This case report will discuss some concerns and tasks in treating patients with obesity and morbid obesity
Real-Time Evaluation of the Effectiveness of Microwave Coagulation Therapy for Hepatocellular Carcinoma Using Color Doppler Imaging
Percutaneous microwave coagulation therapy (PMCT) is a new technique for the treatment of hepatocellular carcinoma (HCC). However, it is difficult to distinguish those lesions in which necrosis has been induced from the viable residual lesions during the procedure, because the margin of the tumor becomes unclear during PMCT. We determined the area of necrotic lesions during the procedure using color Doppler imaging. PMCT was performed on 10 patients (17 lesions) with recurrent HCC. The electrode of the microwave delivery system was moved around the tumor and the surrounding area until color mosaic images disappeared from the entire area of the tumor. The areas in which necrotic tissue was indicated by color Doppler imaging were later confirmed by other modalities such as angiography or contrast-enhanced computed tomography. This leads us to believe that real-time, effective evaluation of PMCT is possible with color Doppler imaging.</p
Detection of Polarimetric Variations Associated with the Shortest Time-Scale Variability in S5 0716714
We present the result of near-infrared and optical observations of the BL Lac
object S5 0716714 carried out by the KANATA telescope. S5 0716714 has
both a long term high-amplitude variability and a short-term variability within
a night. The shortest variability (microvariability) time-scale is important
for understanding the geometry of jets and magnetic field, because it provides
a possible minimum size of variation sources. Here, we report the detection of
15-min variability in S5 0716714, which is one of the shortest time-scales
in optical and near-infrared variations observed in blazars. The detected
microvariation had an amplitude of mag in band and a blue
color of . Furthermore, we successfully detected
an unprecedented, short time-scale polarimetric variation which correlated with
the brightness change. We revealed that the microvariation had a specific
polarization component. The polarization degree of the variation component was
higher than that of the total flux. These results suggest that the
microvariability originated from a small and local region where the magnetic
field is aligned.Comment: 5 pages, 4 figures; Publications of the Astronomical Society of Japan
letter accepte
SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma.
Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data from 178 lung SCC specimens (containing tumor and tumor-associated cells) and analyzed the correlation between SOX2 and previously-reported SOX2-controlled genes in lung SCC. In addition, we used another RNA-seq dataset from 105 non-small cell lung cancer cell lines (NSCLC; including 4 lung SCC cell lines) and again analyzed the correlation between SOX2 and the reported SOX2-controlled genes in the NSCLC cell lines (no tumor-associated cells). We combined the two analyses and identified genes commonly correlated with SOX2 in both datasets. Among the 99 genes reported as SOX2 downstream and/or correlated genes, we found 4 negatively-correlated (e.g., CDKN1A) and 11 positively-correlated genes with SOX2. We used biological studies to demonstrate that CDKN1A was suppressed by SOX2 in lung SCC cells. G1 cell cycle arrest induced by SOX2 siRNA was rescued by CDKN1A siRNA. These results indicate that the tumorigenic effect of SOX2 in lung SCC cells is mediated in part by suppression of CDKN1A
Dwarf Novae in the Shortest Orbital Period Regime: I. A New Short Period Dwarf Nova, OT J055717+683226
We report the observation of a new dwarf nova, OT J055717+683226, during its
first-ever recorded superoutburst in December 2006. Our observation shows that
this object is an SU UMa-type dwarf nova having a very short superhump period
of 76.67+/- 0.03 min (0.05324+/-0.00002 d). The next superoutburst was observed
in March 2008. The recurrence time of superoutbursts (supercycle) is, hence,
estimated to be ~480 d. The supercycle is much shorter than those of WZ
Sge-type dwarf novae having supercycles of >~ 10 yr, which are a major
population of dwarf novae in the shortest orbital period regime (<~85 min).
Using a hierarchical cluster analysis, we identified seven groups of dwarf
novae in the shortest orbital period regime. We identified a small group of
objects that have short supercycles, small outburst amplitudes, and large
superhump period excesses, compared with those of WZ Sge stars. OT
J055717+683226 probably belongs to this group.Comment: 14 pages, 11 figures, accepted for publication in PAS
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