A molecular thermometer based on luminescence of copper(II) tetraphenylporphyrin

The photoluminescence (PL) spectra from solid samples consisting of polystyrene and 5,10,15,20-tetraphenyl-21H,23H-porphine copper(II) (CuTPP) revealed two sharp peaks at 653 and 720 nm, and indicated another broad peak at around 780 nm, which could not be observed in CuTPP solutions. The intensity ratio of the two peaks appearing at 653 nm and at around 780 nm demonstrated clear dependence on temperature. This dependence of the PL intensity ratio was observed under the atmosphere and even in water. The findings mean that we were able to utilize PL from CuTPP as a thermometer under various conditions. We measured the temperatures of an organic light-emitting diode (OLED) during operation based on its electroluminescence, where the OLED contained CuTPP as a light-emitting dopant, to demonstrate the CuTPP thermometer.ArticleThin Solid Films. 518(2):563-566 (2009)journal articl

Indoxyl Sulfate as a Mediator Involved in Dysregulation of Pulmonary Aquaporin-5 in Acute Lung Injury Caused by Acute Kidney Injury

High mortality of acute kidney injury (AKI) is associated with acute lung injury (ALI), which is a typical complication of AKI. Although it is suggested that dysregulation of lung salt and water channels following AKI plays a pivotal role in ALI, the mechanism of its dysregulation has not been elucidated. Here, we examined the involvement of a typical oxidative stress-inducing uremic toxin, indoxyl sulfate (IS), in the dysregulation of the pulmonary predominant water channel, aquaporin 5 (AQP-5), in bilateral nephrectomy (BNx)-induced AKI model rats. BNx evoked AKI with the increases in serum creatinine (SCr), blood urea nitrogen (BUN) and serum IS levels and exhibited thickening of interstitial tissue in the lung. Administration of AST-120, clinically-used oral spherical adsorptive carbon beads, resulted in a significant decrease in serum IS level and thickening of interstitial tissue, which was accompanied with the decreases in IS accumulation in various tissues, especially lung. Interestingly, a significant decrease in AQP-5 expression of lung was observed in BNx rats. Moreover, the BNx-induced decrease in pulmonary AQP-5 protein expression was markedly restored by oral administration of AST-120. These results suggest that BNx-induced AKI causes dysregulation of pulmonary AQP-5 expression, in which IS could play a toxico-physiological role as a mediator involved in renopulmonary crosstalk