The infrared-dark dust content of high redshift galaxies

We present a theoretical model aimed at explaining the IRX-$\beta$ relation for high redshift (z >5) galaxies. Recent observations (Capak+2015; Bouwens+2016) have shown that early Lyman Break Galaxies, although characterized by a large UV attenuation (e.g. flat UV beta slopes), show a striking FIR deficit, i.e. they are "infrared-dark". This marked deviation from the local IRX-beta relation can be explained by the larger molecular gas content of these systems. While dust in the diffuse ISM attains relatively high temperatures (Td = 45 K for typical size a=0.1 um; smaller grains can reach Td = 60 K), a sizable fraction of the dust mass is embedded in dense gas, and therefore remains cold. If confirmed, the FIR deficit might represent a novel, powerful indicator of the molecular content of high-z galaxies which can be used to pre-select candidates for follow-up deep CO observations. Thus, high-z CO line searches with ALMA might be much more promising than currently thought.Comment: 8 pages, 4 Figures, MNRAS Submitte

Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes

<b>Background:</b> Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study. <b>Methods</b> A total of 87 patients were assessed at baseline and following 9 weeks treatment with the angiotensin-receptor blocker telmisartan (final dose, 80 mg; n = 45) or the angiotensin-converting enzyme inhibitor ramipril (final dose, 10 mg; n = 42). Adiponectin levels were measured in plasma by radioimmunoassay. <b>Results:</b> Adiponectin levels were inversely correlated with systolic (SBP; r = -0.240, P < 0.05) and diastolic (DBP; r = -0.227, P < 0.05) blood pressure at baseline and following treatment with telmisartan or ramipril (SBP: r = -0.228, P < 0.05; DBP: r = -0.286, P < 0.05). Changes in adiponectin levels were related to changes in SBP (r = -0.357, P < 0.01) and DBP (r = -0.286, P < 0.01). There was a significant increase in adiponectin levels in the telmisartan (0.68 (95% confidence interval (CI), 0.27 to 1.10) <sup>µ</sup>g/ml, P < 0.01) but not in the ramipril group (0.17 (95% CI, -0.56 to 0.90) <sup>µ</sup>g/ml, P = 0.67). Blood pressure reduction in the telmisartan group (DeltaSBP: -13.5 (95% CI, -17.0 to -10.0) mm Hg; ΔDBP: -7.6 (95% CI, -9.8 to -5.3) mm Hg, each P < 0.001) was significantly (P less than or equal to 0.01 for SBP and P < 0.01 for DBP) greater than in the ramipril group (ΔSBP: -6.1 (95% CI, -6.2 to -2.0) mm Hg; ΔDBP: -2.7 (95% CI, -5.0 to -0.5) mm Hg; P < 0.01 and P < 0.05, respectively). <b>Conclusion:</b> Adiponectin is correlated with blood pressure in patients with type 2 diabetes. Whether increased adiponectin contributes to the blood pressure–lowering effect of telmisartan needs further study

Large Population of ALMA Galaxies at z>6 with Very High [OIII]88um to [CII]158um Flux Ratios: Evidence of Extremely High Ionization Parameter or PDR Deficit?

We present our new ALMA observations targeting [OIII]88um, [CII]158um, [NII]122um, and dust continuum emission for three Lyman break galaxies at z=6.0293-6.2037 identified in the Subaru/Hyper Suprime-Cam survey. We clearly detect [OIII] and [CII] lines from all of the galaxies at 4.3-11.8sigma levels, and identify multi-band dust continuum emission in two of the three galaxies, allowing us to estimate infrared luminosities and dust temperatures simultaneously. In conjunction with previous ALMA observations for six galaxies at z>6, we confirm that all the nine z=6-9 galaxies have high [OIII]/[CII] ratios of L[OIII]/L[CII]~3-20, ~10 times higher than z~0 galaxies. We also find a positive correlation between the [OIII]/[CII] ratio and the Lya equivalent width (EW) at the ~90% confidence level. We carefully investigate physical origins of the high [OIII]/[CII] ratios at z=6-9 using Cloudy, and find that high density of the interstellar medium, low C/O abundance ratio, and the cosmic microwave background attenuation are responsible to only a part of the z=6-9 galaxies. Instead, the observed high [OIII]/[CII] ratios are explained by 10-100 times higher ionization parameters or low photodissociation region (PDR) covering fractions of 0-10%, both of which are consistent with our [NII] observations. The latter scenario can be reproduced with a density bounded nebula with PDR deficit, which would enhance the Lya, Lyman continuum, and C+ ionizing photons escape from galaxies, consistent with the [OIII]/[CII]-Lya EW correlation we find.Comment: 20 pages, 18 figures, Accepted for publication in Ap

EMPRESS. VI. Outflows Investigated in Low-Mass Galaxies with M∗=104−107 M⊙M_*=10^4-10^7~M_\odot: Weak Feedback in Low-Mass Galaxies?

We study emission line profiles of 21 nearby low-mass ($M_*=10^4-10^7~M_\odot$) galaxies in deep medium-high resolution spectra taken with Magellan/MagE. These low-mass galaxies are actively star-forming systems with high specific star-formation rates of $\mathrm{sSFR}\sim100-1000~\mathrm{Gyr}^{-1}$ that are well above the star-formation main sequence and its extrapolation. We identify broad-line components of H$\alpha$ and [OIII]$\lambda 5007$ emission in 14 out of the 21 galaxies that cannot be explained by the MagE instrumental profile or the natural broadening of line emission. We conduct double Gaussian profile fitting to the emission of the 14 galaxies, and find that the broad-line components have line widths significantly larger than those of the narrow-line components, indicative of galactic outflows. The board-line components have moderately large line widths of $\sim 100$ km s$^{-1}$. We estimate the maximum outflow velocities $v_\mathrm{max}$ and obtain values of $\simeq 60-200$ km s$^{-1}$, which are found to be comparable to or slightly larger than the escape velocities. Positive correlations of $v_\mathrm{max}$ with star-formation rates, stellar masses, and circular velocities, extend down into this low-mass regime. Broad- to narrow-line flux ratios BNRs are generally found to be smaller than those of massive galaxies. The small $v_\mathrm{max}$ and BNRs suggest that the mass loading factors $\eta$ can be as small as 0.1 - 1 or below, in contrast to the large $\eta$ of energy-driven outflows predicted by numerical simulations.Comment: 22 pages, 11 figures, Accepted for publication by Ap

Tumour inoculation site-dependent induction of cachexia in mice bearing colon 26 carcinoma

Murine colon 26 carcinoma growing at either subcutaneous (s.c.) or intramuscular (i.m.) inoculation sites causes cachexia in mice. Such animals show extensive loss of body weight, wasting of the muscle and adipose tissues, hypoglycaemia, and hypercalcaemia, even when the tumour weight comprises only about 1.9% of carcass weight. In contrast, the same tumour when inoculated into the liver does not cause any sign of tumour-related cachexia even when the tumour becomes much larger (6.6% of carcass weight). Interleukin 6 (IL-6), a mediator associated with cachexia in this tumour model, is detected at high levels both in the tumour tissues and in the circulating blood of mice bearing colon 26 tumour at the s.c. inoculation site. In contrast, only minute levels of IL-6 are detected in the tumour grown in the liver. The colon 26 tumour grown in the liver does not lose its ability to cause cachexia, because the tumour when re-inoculated s.c. is able to cause extensive weight loss and produce IL-6 as did the original colon 26 cell line. Histological studies revealed differences in the composition of tumour tissues: the tumours grown in the subcutis consist of many polygonal tumour cells, extended-intercellular space, and high vascular density, whereas those grown in the liver consist of spindle-shaped tumour cells. Thus, the environment where tumour cells grow would be a critical factor in determining the cachectic phenotype of cancer cells, including their ability to produce IL-6. 1999 Cancer Research Campaig