Electric currents distributions on finite patch conductor of microstrip antenna

The electric currents on the upper, lower and side surfaces of the finite patchconductor of a circular microstrip antenna are calculated by using the methodof moment in the spectral domain. The electric current on the lower surfaceis much bigger than that on the upper surface and the input impedance ofmicrostrip antenna depends on the electric current on the lower surface.2003 Asia Pacific Microwave Conference, November 4-7, 2003, Sheraton Walkerhill Hotel, Seoul, Kore

Comparison of numerical solutions of hollow cylindrical dipole antennas

The current distributions of hollow cylindrical dipole antennas are calculated by using WIPL-D and AWAS. The relative error of feed point current and the root mean square error of current distribution are compared. As the criterion for accuracy of calculated results, the numerical solutions of Pocklington\u27s integral equation on the antenna surface with the surface current expansion functions satisfying the edge condition at the antenna ends are adopted.ACES-2002, March 18-22, 2002, Monterey, Californi

Wall Admittance of a Circular Microstrip Antenna

The formulation of the wall admittance of a circular microstrip antenna by the spectral domain method is presented. The circular microstrip antenna is calculated using the cavity model. The electromagnetic fields within the antenna cavity are determined from the impedance boundary condition at the side aperture. The contribution from the region outside the antenna is taken into account by the wall admittance. The wall admittance is defined by the magnetic field produced by the equivalent, magnetic current at the aperture. The magnetic field is calculated by the spectral domain method. The wall admittances obtained by this method are compared with the results calculated by Shen. The calculated input impedances of the microstrip antenna agree fairly well with the experimental data for the substrate thickness of up to 0.048λ_g. The formulation of wall admittance presented here is easily applicable to arbitrarily shaped microstrip antennas

Transcription-associated breaks in Xeroderma Pigmentosum group D cells from patients with combined features of Xeroderma Pigmentosum and Cockayne Syndrome

Defects in the XPD gene can result in several clinical phenotypes, including xeroderma pigmentosum (XP), trichothiodystrophy, and, less frequently, the combined phenotype of XP and Cockayne syndrome (XP-D/CS). We previously showed that in cells from two XP-D/CS patients, breaks were introduced into cellular DNA on exposure to UV damage, but these breaks were not at the sites of the damage. In the present work, we show that three further XP-D/CS patients show the same peculiar breakage phenomenon. We show that these breaks can be visualized inside the cells by immunofluorescence using antibodies to either gamma-H2AX or poly-ADP-ribose and that they can be generated by the introduction of plasmids harboring methylation or oxidative damage as well as by UV photoproducts. Inhibition of RNA polymerase II transcription by four different inhibitors dramatically reduced the number of UV-induced breaks. Furthermore, the breaks were dependent on the nucleotide excision repair (NER) machinery. These data are consistent with our hypothesis that the NER machinery introduces the breaks at sites of transcription initiation. During transcription in UV-irradiated XP-D/CS cells, phosphorylation of the carboxy-terminal domain of RNA polymerase II occurred normally, but the elongating form of the polymerase remained blocked at lesions and was eventually degraded

Magnetic Reconnection by a Self-Retreating X-Line

Particle-in-cell (PIC) simulations of collisionless magnetic reconnection are performed to study asymmetric reconnection in which an outflow is blocked by a hard wall while leaving sufficiently large room for the outflow of the opposite direction. This condition leads to a slow, roughly constant motion of the diffusion region away from the wall, the so-called `X-line retreat'. The typical retreat speed is ~0.1 times the Alfven speed. At the diffusion region, ion flow pattern shows strong asymmetry and the ion stagnation point and the X-line are not collocated. A surprise, however, is that the reconnection rate remains the same unaffected by the retreat motion.Comment: 4 pages; Phys. Rev. Lett., in pres

Novel Hybrid Hydroxyapatite Spacers Ensure Sufficient Bone Bonding in Cervical Laminoplasty

Study Design Prospective observational study. Purpose This prospective analysis aimed to evaluate the efficacy and bone-bonding rate of hybrid hydroxyapatite (HA) spacers in expansive laminoplasty. Overview of Literature Various types of spacers or plates have been developed for expansive laminoplasty. Methods Expansive open-door laminoplasty was performed in 146 patients with cervical myelopathy; 450 hybrid HA spacers and 41 autogenous bone spacers harvested from the spinous processes were grafted into the opened side of each lamina. The patients were followed up using computed tomography (CT), and their bone-bonding rates for hybrid HA and autogenous spacers, bone-fusion rates of the hinges of the laminae, and complications associated with the implants were then examined. Results Clinical symptoms significantly improved in all patients, and no major complications related to the procedure were noted. The hybrid HA spacers exhibited sufficient bone bonding on postoperative CT. The hinges completely fused in over 95% patients within 1 year of the procedure. Only 4 spacers (0.9%) developed lamina sinking, and most expanded laminae maintained their positions without sinking or floating throughout the follow-up period. Conclusions Hybrid HA spacers contributed to high bone-fusion rates of the spacers and hinges of the laminae, and no complications were associated with their use. Cervical laminoplasty with these spacers is safe and simple, and it yields sufficient fixation strength while ensuring sufficient bone bonding during the immediate postoperative period

シンコウ イガン ニ タイスル フククウキョウ ケンサゴ ニ SIADH オ ハッショウシタ 1レイ

We report here a case of advanced gastric cancer complicated by Syndrome of Inappropriate Secretion of Antidiuretic Hormone（SIADH）following staging laparoscopy. A ５５ year-old male developed nausea, and was found with a poorly differentiated adenocarcinoma of stomach（UE, type4, cT 3, cN2, cM0, cStage ⅢB）. He was done with staging laparoscopy. The serum sodium concentration decreased from１３８mEq/l to１１４mEq/l after operation. SIADH was diagnosed on the basis of hyponatremia with corresponding serum hypoosmolality and an inappropriate high urinary osmolality due to continued sodium excretion. Fluid restriction and sodium supplement resulted in an appropriate rise in the serum sodium level to１２８mEq/l in ４ days

Downregulation of microRNA-100/microRNA-125b

A majority of early colorectal cancers (CRCs) with submucosal invasion undergo surgical operation, despite a very low incidence of lymph node metastasis. Our study aimed to identify microRNAs (miRNAs) specifically responsible for lymph node metastasis in submucosal CRCs. MicroRNA microarray analysis revealed that miR-100 and miR-125b expression levels were significantly lower in CRC tissues with lymph node metastases than in those without metastases. These results were validated by quantitative real-time PCR in a larger set of clinical samples. The transfection of a miR-100 or miR-125b inhibitor into colon cancer HCT116 cells significantly increased cell invasion, migration, and MMP activity. Conversely, overexpression of miR-100 or miR-125b mimics significantly attenuated all these activities but did not affect cell growth. To identify target mRNAs, we undertook a gene expression array analysis of miR-100-silenced HCT116 cells as well as negative control cells. The Ingenuity Pathway Analysis, TargetScan software analyses, and subsequent verification of mRNA expression by real-time PCR identified mammalian target of rapamycin (mTOR) and insulin-like growth factor 1 receptor (IGF1R) as direct, and Fas and X-linked inhibitor-of-apoptosis protein (XIAP) as indirect candidate targets for miR-100 involved in lymph node metastasis. Knockdown of each gene by siRNA significantly reduced the invasiveness of HCT116 cells. These data clearly show that downregulation of miR-100 and miR-125b is closely associated with lymph node metastasis in submucosal CRC through enhancement of invasion, motility, and MMP activity. In particular, miR-100 may promote metastasis by upregulating mTOR, IGF1R, Fas, and XIAP as targets. Thus, miR-100 and miR-125b may be novel biomarkers for lymph node metastasis of early CRCs with submucosal invasion

Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1

Aberrant crypt foci (ACF), the earliest precursor lesion of colorectal cancers (CRCs), are a good surrogate marker for CRC risk stratification and chemoprevention. However, the conventional ACF detection method with dye-spraying by magnifying colonoscopy is labor- and skill-intensive. We sought to identify rat and human ACF using a fluorescent imaging technique that targets a molecule specific for ACF. We found that glutathione S-transferase (GST) P1-1 was overexpressed in ACF tissues in a screening experiment. We then synthesized the fluorogenic probe, DNAT-Me, which is fluorescently quenched but is activated by GSTP1-1. A CRC cell line incubated with DNAT-Me showed strong fluorescence in the cytosol. Fluorescence intensities correlated significantly with GST activities in cancer cell lines. When we sprayed DNAT-Me onto colorectal mucosa excised from azoxymethane-treated rats and surgically resected from CRC patients, ACF with strong fluorescent signals were clearly observed. The ACF number determined by postoperative DNAT-Me imaging was almost identical to that determined by preoperative methylene blue staining. The signal-to-noise ratio for ACF in DNAT-Me images was significantly higher than that in methylene blue staining. Thus, we sensitively visualized ACF on rat and human colorectal mucosa by using a GST-activated fluorogenic probe without dye-spraying and magnifying colonoscopy