13 research outputs found
An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A
The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the α subunit of the eukaryotic translation initiation factor 2 (eIF2α) to inhibit protein translation. A broad range of regulatory functions has also been attributed to PKR. However, as few additional PKR substrates have been identified, the mechanisms remain unclear. Here, PKR is shown to interact with an essential RNA helicase, RHA. Moreover, RHA is identified as a substrate for PKR, with phosphorylation perturbing the association of the helicase with double-stranded RNA (dsRNA). Through this mechanism, PKR can modulate transcription, as revealed by its ability to prevent the capacity of RHA to catalyze transactivating response (TAR)–mediated type 1 human immunodeficiency virus (HIV-1) gene regulation. Consequently, HIV-1 virions packaged in cells also expressing the decoy RHA peptides subsequently had enhanced infectivity. The data demonstrate interplay between key components of dsRNA metabolism, both connecting RHA to an important component of innate immunity and delineating an unanticipated role for PKR in RNA metabolism
68Gallium-labelled prostate-specific membrane antigen ligand (68Ga-PSMA-11) promising radiotracer for PET/MRI or PET/CT of prostate cancer
C3 IS PRO PSA MORE CANCER SPECIFIC FORM OF PROSTATE SPECIFIC ANTIGEN FOR THE EARLY DETECTION OF PROSTATE CANCER?
Synergistic effect of low K and D vitamin status on arterial stiffness in a general population
The Ability of Prostate Health Index (PHI) to Predict Gleason Score in Patients With Prostate Cancer and Discriminate Patients Between Gleason Score 6 and Gleason Score Higher Than 6—A Study on 320 Patients After Radical Prostatectomy
Reproductive System Augmented Reality Application for Sexual Health Classes
This study aims to evaluate a reproductive systems augmented reality (AR) application for use in sexual health education. AR material included learner interactivity and a 3D video. Sixteen counselor candidates voluntarily registered to the sexual health class. A Reproductive Systems Questionnaire and an AR interview form were used to collect data. The participants were evaluated with a pretest, post-test and retention test. A significant improvement from pretest to post-test indicated that the AR application enhanced participants' knowledge of reproductive organs and their positions. Participants learned more about female reproductive systems than male reproductive systems