50 research outputs found
Lean Management en la industria farmacéutica, el caso de BAYER AG en China = Lean Management in the pharmaceutical industry, the Case of BAYER AG in China
Hoy en día, el sistema de gestión se ha convertido en un elemento clave para mejorar la competitividad en las compañías. Y entre todas las formas de gestión, el Lean Management es una de las más destacadas en la actualidad. En este Trabajo Fin de Grado se pretende profundizar el conocimiento de Lean Management desde distintas perspectivas como son sus elementos clave, herramientas que utiliza, concepto de desperdicios, etc.
Además, para verificar la aplicación de Lean Management en la industria farmacéutica, el presente trabajo se ha enfocado en la aplicación práctica de Lean Management en la empresa Bayer AG, líder de la industria farmacéutica en todo el mundo. A través del caso de un proyecto de OEM entre Bayer AG y XH Pharma (gran empresa farmacéutica en China), se lleva a cabo el análisis de la implantación del Lean Management en dicha empresa, analizando –con la información disponible- los puntos en los que se ha aplicado y las mejoras obtenidas presumiblemente con dicha implementación, para concluir la conveniencia de aplicar este sistema de gestión en este sector.
El trabajo realizado ha permitido concluir que el Lean Management es una forma de gestión para toda la industria farmacéutica, pero las empresas tienen que implementar las herramientas adecuadas a su situación cuando implantan este sistem
Recommended from our members
Climate warming accelerates temporal scaling of grassland soil microbial biodiversity.
Determining the temporal scaling of biodiversity, typically described as species-time relationships (STRs), in the face of global climate change is a central issue in ecology because it is fundamental to biodiversity preservation and ecosystem management. However, whether and how climate change affects microbial STRs remains unclear, mainly due to the scarcity of long-term experimental data. Here, we examine the STRs and phylogenetic-time relationships (PTRs) of soil bacteria and fungi in a long-term multifactorial global change experiment with warming (+3 °C), half precipitation (-50%), double precipitation (+100%) and clipping (annual plant biomass removal). Soil bacteria and fungi all exhibited strong STRs and PTRs across the 12 experimental conditions. Strikingly, warming accelerated the bacterial and fungal STR and PTR exponents (that is, the w values), yielding significantly (P < 0.001) higher temporal scaling rates. While the STRs and PTRs were significantly shifted by altered precipitation, clipping and their combinations, warming played the predominant role. In addition, comparison with the previous literature revealed that soil bacteria and fungi had considerably higher overall temporal scaling rates (w = 0.39-0.64) than those of plants and animals (w = 0.21-0.38). Our results on warming-enhanced temporal scaling of microbial biodiversity suggest that the strategies of soil biodiversity preservation and ecosystem management may need to be adjusted in a warmer world
Recommended from our members
The incidence of congenital hypothyroidism (CH) in Guangxi, China and the predictors of permanent and transient CH
Background: The incidence of congenital hypothyroidism (CH) differs significantly among different ethnicities and regions, and early differentiation of transient CH is important to avoid unnecessary prolonged treatment with L-T4. Objective: To investigate the incidence of CH based on the newborn screening program in Guangxi Zhuang Autonomous Region, China, and to analyze the predictors that might allow for an early differentiation between permanent (P) and transient (T) CH. Design and methods Data from newborn screening program over a seven-year period (January 2009 to January 2016) at Guangxi Maternal and Child Health Hospital are analyzed. Blood samples were collected on filter paper between 3 and 7 days after birth, and TSH level was measured by time-resolved fluorescence assay. Individuals with increased TSH (TSH ≥ 8 IU/L) levels detected by newborn screening were recalled for further evaluation. Serum TSH, FT3 and FT4 were determined by electrochemiluminescence assay using venous blood samples. Diagnosis of CH is based on elevated TSH levels (>10 IU/L) and decreased FT4 levels (30 μg/day) has the highest predictive value for PCH. Earlier differentiation of PCH and TCH helps to determine appropriate treatment course
Search for light dark matter from atmosphere in PandaX-4T
We report a search for light dark matter produced through the cascading decay
of mesons, which are created as a result of inelastic collisions between
cosmic rays and Earth's atmosphere. We introduce a new and general framework,
publicly accessible, designed to address boosted dark matter specifically, with
which a full and dedicated simulation including both elastic and quasi-elastic
processes of Earth attenuation effect on the dark matter particles arriving at
the detector is performed. In the PandaX-4T commissioning data of 0.63
tonneyear exposure, no significant excess over background is observed.
The first constraints on the interaction between light dark matter generated in
the atmosphere and nucleus through a light scalar mediator are obtained. The
lowest excluded cross-section is set at for
dark matter mass of MeV and mediator mass of 300 MeV. The
lowest upper limit of to dark matter decay branching ratio is
A Search for Light Fermionic Dark Matter Absorption on Electrons in PandaX-4T
We report a search on a sub-MeV fermionic dark matter absorbed by electrons
with an outgoing active neutrino using the 0.63 tonne-year exposure collected
by PandaX-4T liquid xenon experiment. No significant signals are observed over
the expected background. The data are interpreted into limits to the effective
couplings between such dark matter and electrons. For axial-vector or vector
interactions, our sensitivity is competitive in comparison to existing
astrophysical bounds on the decay of such dark matter into photon final states.
In particular, we present the first direct detection limits for an axial-vector
(vector) interaction which are the strongest in the mass range from 25 to 45
(35 to 50) keV/c