704 research outputs found
4,5,6,7-Tetrachloro-N-(2-fluorophenyl)phthalimide
In the title compound, C14H4Cl4FNO2, the benzene ring and the phthalimide plane are nearly planar, the maximum deviations being 0.005 (2) and 0.010 (2) Å, respectively, but the molecule as a whole is not planar: the dihedral angle between the two planar ring systems is 68.06 (10)°. A short Cl⋯O contact of 2.914 (2) Å exists in the crystal structure
STAGE: Span Tagging and Greedy Inference Scheme for Aspect Sentiment Triplet Extraction
Aspect Sentiment Triplet Extraction (ASTE) has become an emerging task in
sentiment analysis research, aiming to extract triplets of the aspect term, its
corresponding opinion term, and its associated sentiment polarity from a given
sentence. Recently, many neural networks based models with different tagging
schemes have been proposed, but almost all of them have their limitations:
heavily relying on 1) prior assumption that each word is only associated with a
single role (e.g., aspect term, or opinion term, etc. ) and 2) word-level
interactions and treating each opinion/aspect as a set of independent words.
Hence, they perform poorly on the complex ASTE task, such as a word associated
with multiple roles or an aspect/opinion term with multiple words. Hence, we
propose a novel approach, Span TAgging and Greedy infErence (STAGE), to extract
sentiment triplets in span-level, where each span may consist of multiple words
and play different roles simultaneously. To this end, this paper formulates the
ASTE task as a multi-class span classification problem. Specifically, STAGE
generates more accurate aspect sentiment triplet extractions via exploring
span-level information and constraints, which consists of two components,
namely, span tagging scheme and greedy inference strategy. The former tag all
possible candidate spans based on a newly-defined tagging set. The latter
retrieves the aspect/opinion term with the maximum length from the candidate
sentiment snippet to output sentiment triplets. Furthermore, we propose a
simple but effective model based on the STAGE, which outperforms the
state-of-the-arts by a large margin on four widely-used datasets. Moreover, our
STAGE can be easily generalized to other pair/triplet extraction tasks, which
also demonstrates the superiority of the proposed scheme STAGE.Comment: Accepted by AAAI 202
4,5,6,7-Tetrachloro-2-(4-fluorophenyl)isoindoline-1,3-dione
The title compound, C14H4Cl4FNO2, has crystallographic twofold symmetry with the N and F atoms and two C atoms of the benzene ring located on a twofold rotation axis. The isoindoledione ring system is almost planar [maximum atomic deviation = 0.036 (3) Å], and is twisted with respect to the florobenzene ring, making a dihedral angle of 58.56 (16)°. Weak intermolecular C—H⋯Cl hydrogen bonding is present in the crystal structure
4,5,6,7-Tetrachloro-2-(2,2,2-trifluoroethyl)isoindoline-1,3-dione
In the title compound, C10H2Cl4F3NO2, the isoindoline ring system is almostplanar, the maximum atomic deviation being 0.064 (2) Å. The C—C bond of the ethylene group is twisted with respect to the isoindoline plane by a dihedral angle of 59.58 (12)°. In the crystal, weak intermolecular C—H⋯F hydrogen bonding links the molecules into supramolecular chains running along the a axis. A short intermolecular Cl⋯O contact of 2.950 (3) Å is also observed
2-(2,2,2-Trifluoroethyl)isoindoline-1,3-dione
In the title compound, C10H6F3NO2, the isoindole ring system is planar, the maximum atomic deviation being 0.012 (2) Å. The C—C bond of the trifluoroethyl group is twisted with respect to the isoindole ring by a dihedral angle of 62.58 (17)°. Weak intermolecular C—H⋯O and C—H⋯F hydrogen bonding is present in the crystal structure
N-(3,4-Difluorophenyl)phthalimide
In the title compound, C14H7F2NO2, the phthalimide ring system is nearly planar [maximum atomic deviation = 0.028 (1) Å] and it is twisted with respect to the attached benzene ring, making a dihedral angle of 55.70 (6)°. Weak intermolecular C—H⋯F hydrogen bonds are present in the crystal structure
Cross-cultural differences in consumers' attention to food labels
Purpose: Extended from Hofstede’s cultural framework, this study investigated the differences between the Australian (representing the Western culture) and Chinese (representing the Eastern Culture) consumers in regard to their attention paid to product attribute cues presented on food labels and the degree of such attention controlling for an individual-level moderator of product involvement.
Design/methodology/approach: Data were collected using face-to-face interviews with semi-structured questionnaires for both Australian and Chinese samples. The questionnaire data were analysed using factorial between-groups analysis of variance (ANOVA) to investigate the influence of culture and product involvement on the attention paid/degree of attention to product nature-related (e.g. brand name), product assurance-related (e.g. country-of-origin) and health-related attribute (e.g. nutritional panel) cues.
Findings: The findings revealed that Chinese consumers, as compared to Australian consumers, paid attention to more product-assurance cues (i.e. country of origin) and health-related cues (i.e. bioactivity indicators). The degrees of attention to these cues were also greater among Chinese consumers than for Australian consumers. Product involvement moderated the relationship between culture and attention towards product nature and product assurance-related cues.
Practical implications: Results from this study enable exporters to customize their labelling design by strategically including label information that is more salient to certain export markets.
Originality/value: This study offers a novel insight into the impact of culture on consumers’ attention to food product attributes and the interaction effects of product involvement on these relationships, hitherto underexplored
(2,9-Diethoxy-1,10-phenanthroline-κ2 N,N′)bis(thiocyanato-κN)cobalt(II)
In the title complex, [Co(NCS)2(C16H16N2O2)], the CoII ion is coordinated by two N atoms from one 2,9-diethoxy-1,10-phenanthroline ligand and two N atoms from two different thiocyanate ligands in a distorted tetrahedral environment. The Co—N bonds involving the thiocyanate ligands are significantly shorter than the other two Co—N bonds. The atoms of one of the ethoxy groups are essentially coplanar with the phenanthroline ring [N=C—O—C = 178.8 (4)°], while the other ethoxy group is slightly twisted from the phenanthroline ring plane [N=C—O—C = 167.2 (4)°]. In the crystal structure, there is a weak π–π stacking interaction between two symmetry-related phenanthroline rings with a centroid–centroid distance of 3.706 (4) Å
MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer
Background
We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. Here we aim to elucidate the role of miR-1 in gastric carcinogenesis.
Methods
We measured miR-1 expression in human GC cell lines and 90 paired primary GC samples, and analyzed the association of its status with clinicopathological features. The effect of miR-1 on GC cells was evaluated by proliferation and migration assay. To identify the target genes of miR-1, bioinformatic analysis and protein array analysis were performed. Moreover, the regulation mechanism of miR-1 with regard to these predicted targets was investigated by quantitative PCR (qPCR), Western blot, ELISA, and endothelial cell tube formation. The putative binding site of miR-1 on target genes was assessed by a reporter assay.
Results
Expression of miR-1 was obviously decreased in GC cell lines and primary tissues. Patients with low miR-1 expression had significantly shorter overall survival compared with those with high miR-1 expression (P = 0.0027). Overexpression of miR-1 in GC cells inhibited proliferation, migration, and tube formation of endothelial cells by suppressing expression of vascular endothelial growth factor A (VEGF-A) and endothelin 1 (EDN1). Conversely, inhibition of miR-1 with use of antago-miR-1 caused an increase in expression of VEGF-A and EDN1 in nonmalignant GC cells or low-malignancy GC cells.
Conclusions
MiR-1 acts as a tumor suppressor by inhibiting angiogenesis-related growth factors in human gastric cancer. Downregulated miR-1 not only promotes cellular proliferation and migration of GC cells, but may activates proangiogenesis signaling and stimulates the proliferation and migration of endothelial cells, indicating the possibility of new strategies for GC therapy
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