Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder

AbstractAutism spectrum disorder (ASD) affects a significant number of individuals in the United States, with the prevalence continuing to grow. A significant proportion of individuals with ASD have comorbid medical conditions such as epilepsy. In fact, treatment-resistant epilepsy appears to have a higher prevalence in children with ASD than in children without ASD, suggesting that current antiepileptic treatments may be suboptimal in controlling seizures in many individuals with ASD. Many individuals with ASD also appear to have underlying metabolic conditions. Metabolic conditions such as mitochondrial disease and dysfunction and abnormalities in cerebral folate metabolism may affect a substantial number of children with ASD, while other metabolic conditions that have been associated with ASD such as disorders of creatine, cholesterol, pyridoxine, biotin, carnitine, γ-aminobutyric acid, purine, pyrimidine, and amino acid metabolism and urea cycle disorders have also been associated with ASD without the prevalence clearly known. Interestingly, all of these metabolic conditions have been associated with epilepsy in children with ASD. The identification and treatment of these disorders could improve the underlying metabolic derangements and potentially improve behavior and seizure frequency and/or severity in these individuals. This paper provides an overview of these metabolic disorders in the context of ASD and discusses their characteristics, diagnostic testing, and treatment with concentration on mitochondrial disorders. To this end, this paper aims to help optimize the diagnosis and treatment of children with ASD and epilepsy.This article is part of a Special Issue entitled “Autism and Epilepsy”

Advanced Engineering Laboratory project summaries 1992

The Advanced Engineering Laboratory of the Woods Hole Oceanographic Institution is a development laboratory within the Applied Ocean Physics and Engineering Deparment. Its function is the development of oceanographic instrumentation to test developing theories in oceanography, and to enhance current research projects in other disciplines within the community. This report summarzes recent and ongoing projects perfomied by members of this laboratory

Advanced Engineering Lab project summaries 1991

The Advanced Engineering Laboratory of the Woods Hole Oceanographic Institution is a development laboratory within the Applied Ocean Physics and Engineering Department. Its function is the development of oceanographic instrumentation to test developing theories in oceanography, and to enhance current research projects in other disciplines within the community. This report summarizes recent and ongoing projects performed by members of this laboratory

Alien Registration- Frye, Richard E. (Bowdoin, Sagadahoc County)

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Advanced Engineering Laboratory project summaries : 1995-1996

The Advanced Engineering Laboratory of the Woods Hole Oceanographic Institution is a development laboratory within the Applied Ocean Physics and Engineering Department. Its function is the development of oceanographic instrumentation to test developing theories in oceanography and to enhance current research projects in other disciplines within the community. This report summarizes recent and ongoing projects performed by members of this laboratory

Advanced Engineering Laboratory project summaries 1994

The Advanced Engineering Laboratory of the Woods Hole Oceanographic Institution is a development laboratory within the Applied Ocean Physics and Engineering Department. Its function is the development of oceanographic instrumentation to test developing theories in oceanography and to enhance current research projects in other disciplines within the community. This report summarizes recent and ongoing projects performed by members of this laboratory