3 research outputs found
Female Anal Sphincter: Age-related Differences in Asymptomatic Volunteers with High-Frequency Endoanal US
Skeletal muscle–derived cell implantation for the treatment of fecal incontinence : a randomized, placebo-controlled study
Background and Aims: Fecal incontinence (FI) improvement following injection of autologous skeletal muscle–derived cells has been previously suggested. This study aimed to test the efficacy and safety of said cells through a multicenter, placebo-controlled study, to determine an appropriate cell dose, and to delineate the target patient population that can most benefit from cell therapy. Methods: Patients experiencing FI for at least 6 months were randomized to receive a cell-free medium or low or high dose of cells. All patients received pelvic floor electrical stimulation before and after treatment. Incontinence episode frequency (IEF), FI quality of life, FI burden assessed on a visual analog scale, Wexner score, and parameters reflecting anorectal physiological function were all assessed for up to 12 months. Results: Cell therapy improved IEF, FI quality of life, and FI burden, reaching a preset level of statistical significance in IEF change compared with the control treatment. Post hoc exploratory analyses indicated that patients with limited FI duration and high IEF at baseline are most responsive to cells. Effects prevailed or increased in the high cell count group from 6 to 12 months but plateaued or diminished in the low cell count and control groups. Most physiological parameters remained unaltered. No unexpected adverse events were observed. Conclusions: Injection of a high dose of autologous skeletal muscle–derived cells followed by electrical stimulation significantly improved FI, particularly in patients with limited FI duration and high IEF at baseline, and could become a valuable tool for treatment of FI, subject to confirmatory phase 3 trial(s). (ClinicalTrialRegister.eu; EudraCT Number: 2010-021463-32)
Management von Dammrissen dritten und vierten Grades nach vaginaler Geburt. Leitlinie der DGGG, OEGGG und SGGG (S2k-Level, AWMF-Register Nr. 015/079, Dezember 2020)
Purpose This guideline provides recommendations for the diagnosis, treatment and follow-up care of 3rd and 4th degree perineal tears which occur during vaginal birth. The aim is to improve the management of 3rd and 4th degree perineal tears and reduce the immediate and long-term damage. The guideline is intended for midwives, obstetricians and physicians involved in caring for high-grade perineal tears. Methods A selective search of the literature was carried out. Consensus about the recommendations and statements was achieved as part of a structured process during a consensus conference with neutral moderation. Recommendations After every vaginal birth, a careful inspection and/or palpation by the obstetrician and/or the midwife must be carried out to exclude a 3rd or 4th degree perineal tear. Vaginal and anorectal palpation is essential to assess the extent of birth trauma. The surgical team must also include a specialist physician with the appropriate expertise (preferably an obstetrician or a gynecologist or a specialist for coloproctology) who must be on call. In exceptional cases, treatment may also be delayed for up to 12 hours postpartum to ensure that a specialist is available to treat the individual layers affected by trauma. As neither the end-to-end technique nor the overlapping technique have been found to offer better results for the management of tears of the external anal sphincter, the surgeon must use the method with which he/she is most familiar. Creation of a bowel stoma during primary management of a perineal tear is not indicated. Daily cleaning of the area under running water is recommended, particularly after bowel movements. Cleaning may be carried out either by rinsing or alternate cold and warm water douches. Therapy should also include the postoperative use of laxatives over a period of at least 2 weeks. The patient must be informed about the impact of the injury on subsequent births as well as the possibility of anal incontinence.Ziel Die Leitlinie soll insbesondere durch Empfehlungen zu Diagnostik, Therapie und Nachsorge nach höhergradigen Dammrissen im Rahmen vaginaler Geburten das Management dieser Situationen verbessern und mitwirken, unmittelbare sowie langzeitige Folgeschäden zu reduzieren. Die Leitlinie richtet sich an Hebammen, an geburtshilflich tätige Ärztinnen und Ärzte sowie an Ärztinnen und Ärzte, die in die Versorgung von höhergradigen Dammrissen involviert sind.
Methoden Es erfolgte eine selektive Literaturrecherche. Die strukturierte Konsensfindung der Empfehlungen und Statements erfolgte bei der Konferenz unter neutraler Moderation.
Empfehlungen Nach jeder vaginalen Geburt soll ein Dammriss III°/IV° zunächst durch sorgfältige Inspektion und/oder Palpation durch den Geburtshelfer und/oder die Hebamme ausgeschlossen werden. Die vaginale sowie anorektale Palpation zur Evaluierung von Geburtsverletzungen sind dabei un- abdingbar. Im Operationsteam soll ein Facharzt mit ausreichender Erfahrung (vorrangig Facharzt für Frauenheilkunde und Geburtshilfe oder Facharzt mit koloproktologischer Expertise) zur Verfügung stehen. In Ausnahmefällen kann die Versorgung auch bis zu 12 Stunden postpartal durchgeführt werden, um eine fachgerechte Versorgung in den einzelnen, durch das Trauma einbezogenen Schichten, zu gewährleisten. Da weder die Stoß-auf-Stoß-Technik noch die überlappende Technik in der Versorgung des Risses des M. sphincter ani externus eine Überlegenheit gezeigt hat, soll der Operateur die Methode, bei der die größere Routine besteht, zur Anwendung bringen. Hierbei soll die Anlage eines Anus praeters im Rahmen der primären Versorgung nicht vorgenommen werden. Eine tägliche Reinigung mit fließendem Wasser, insbesondere nach dem Stuhlgang, wird empfohlen. Diese kann z. B. als Spülung oder Wechseldusche durchgeführt werden. Die postoperative Gabe von Laxanzien sollte über eine Therapiedauer von zumindest 2 Wochen erfolgen. Eine Aufklärung über das Vorgehen bei Folgegeburten wie auch einer potenziellen analen Inkontinenz soll erfolgen