PPARs and RXRs in Male and Female Fertility and Reproduction

International audienc

Indicateurs de santé dans la population d'un complexe agro-industriel du Sud Cameroun

Pour étudier la répercussion sur l'état sanitaire de la population de l'implantation d'un programme de développement agro-industriel (culture de canne à sucre) au Cameroun dans les années 60 (ville de Mbandjock), nous avons analysé la distribution des prévalences des principales pathologies parasitaires par quartier, groupe ethnique, âge et sexe. Trois enseignements peuvent être retirés de ce travail : dans la zone d'étude, le développement économique ne semble pas s'être accompagné d'une dégradation de l'état de santé, puisqu'au contraire les pathologies recherchées se sont avérées moins fréquentes que dans les régions avoisinantes; les pathologies importées (loase, schistosomose) ne se sont manifestement pas implantées localement en dépit des concentrations de population entraînées par l'installation du complexe agro-industriel; les parasitoses sévissant à l'état endémique dans la région (paludisme, onchocercose, helminthiases et protozooses intestinales) sont essentiellement groupées dans quelques quartiers (pas nécessairement défavorisés sur le plan socio-économique) qui devraient faire l'objet de mesures d'intervention intégrées

Imaging along-strike variations in mechanical properties of the Gofar transform fault, East Pacific Rise

Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 119 (2014): 7175–7194, doi:10.1002/2014JB011270.A large part of global plate motion on mid-ocean ridge transform faults (RTFs) is not accommodated as major earthquakes. When large earthquakes do occur, they often repeat quasiperiodically. We focus here on the high slip rate (∼14 cm/yr) Gofar transform fault on the equatorial East Pacific Rise. This fault is subdivided into patches that slip during Mw 5.5–6 earthquakes every 5 to 6 years. These patches are separated by rupture barriers that accommodate slip through swarms of smaller events and/or aseismic creep. We performed an imaging study to investigate which spatiotemporal variations of the fault zone properties control this segmentation in mechanical behavior and could explain the specific behavior of RTFs at the global scale. We adopt a double-difference approach in a joint inversion of active air gun shots and microseismicity recorded for 1 year. This data set includes the 2008 Mw 6 Gofar earthquake. The along-strike P wave velocity structure reveals an abrupt transition between the barrier area, characterized by a damaged fault zone of 10–20% reduced Vp and a nearly intact fault zone in the asperity area. The importance of the strength of the damage zone on the mechanical behavior is supported by the temporal S wave velocity changes which suggest increased damage within the barrier area, during the week preceding the Mw 6 earthquake. Our results support the conclusion that extended highly damaged zones are the key factor in limiting the role of major earthquakes to accommodate plate motion along RTFs.The material presented here is based on work supported by the National Science Foundation grants 1232725 and 0242117.2015-03-2

Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome

International audienceFree fatty acid receptors (FFAR) belong to a family of five G-protein coupled receptors that are involved in the regulation of lipidmetabolism, so that their loss of function increases the risk of obesity. The aim of this study was to determine the expansion of genesencoding paralogs of FFAR2 in the chicken, considered as amodel organism for developmental biology and biomedical research. Byestimating the gene copy number using quantitative polymerase chain reaction, genomic DNA resequencing, and RNA sequencingdata, we showed the existence of 23 ±1.5 genes encoding FFAR2 paralogs in the chicken genome. The FFAR2 paralogs shared anidentity from 87.2%up to 99%. Extensive gene conversion was responsible for this high degree of sequence similarities betweenthese genes, and this concerned especially the four amino acids known to be critical for ligand binding. Moreover, elevated nonsynonymous/synonymous substitutionratios onsomeamino acids withinor inclose-vicinity of the ligand-bindinggroove suggest thatpositive selectionmay have reduced the effective rate of gene conversion in this region, thus contributing to diversify the function ofsome FFAR2 paralogs. All the FFAR2 paralogs were located on a microchromosome in a same linkage group. FFAR2 genes wereexpressed in different tissues and cells such as spleen, peripheral blood mononuclear cells, abdominal adipose tissue, intestine, andlung, with the highest rate of expression in testis. Further investigations are needed to determine whether these chicken-specificevents along evolution are the consequence of domestication and may play a role in regulating lipid metabolism in this species