The effect of serum lipids and spermoplasm on the stallion sperm quality

The quality and cryoresistance of stallion sperm depend on many endogenous and exogenous factors. One of the factors affecting the sperm quality are the parameters of the lipid spectrum of spermoplasm and blood serum. Lipase activity, cholesterol and triglyceride content in blood serum and spermoplasm were studied in 19 stallions of the Arabian breed aged from 5 years to 15 years (on average 10.1±0.3 years). It was found that lipase activity in the spermoplasm (217.0 U/l) is on average 11.4 times higher than in the blood serum (19.1 U/l). The concentration of spermoplasm triglycerides (1.3 mmol/l) is on average 4.3 times higher than in blood serum (0.3 mmol/l). The concentration of cholesterol in the blood serum (2.4 mmol/ l) is on average 12 times higher than the same indicator in the stallion spermoplasm (0.2 mmol/l). The relationship between the parameters of the lipid spectrum of blood serum and spermoplasm with the characteristics of stallion sperm was studied. A significant relationship was found between the activity of lipase in blood serum with progressive mobility (r=0.66; p=0.006) and survival (r=0.67; p=0.005) of spermatozoa in cryopreserved sperm

Risk of pre-term birth as a function of sleep quality and obesity: prospective analysis in a large Prematurity Research Cohort

STUDY OBJECTIVE: To investigate whether poor sleep quality is associated with pre-term birth (PTB) risk, overall and independent of sleep apnea and habitual snoring. METHODS: We used longitudinal data from the Washington University Prematurity Research Cohort to investigate the association between poor sleep quality (defined as a Pittsburgh Sleep Quality Index > 5) and PTB, overall and independent of sleep apnea and snoring (defined by the Berlin questionnaire and prior sleep clinic attendance). Associations were investigated for sleep quality early and throughout pregnancy. Stratified analyses were performed by factors previously shown to modify associations between sleep and PTB (race, pre-pregnancy obesity). RESULTS: Of the 976 eligible participants, 50.1% experienced poor sleep quality early in pregnancy (<20 completed weeks) and 14.2% delivered pre-term (n = 50 without and 89 with poor sleep quality). In multivariable-adjusted analyses, poor sleep quality early in pregnancy was associated with increased PTB risk (hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.02-2.14). This association persisted after further adjustment for sleep apnea and snoring (HR = 1.50, 95% CI = 1.02-2.20) and in analyses stratified by race. It varied, however, by pre-pregnancy obesity. Among individuals without obesity, no association was observed between poor sleep and PTB (HR = 1.08, 95% CI = 0.65-1.79), whereas among those with obesity, a positive association was observed (HR = 2.94, 95% CI = 1.52-5.69, p-interaction = .05). This association was limited to individuals with obesity who experienced poor sleep both earlier and later in pregnancy (HR = 3.94, 95% CI = 1.56-9.99). CONCLUSION: Our findings suggest that improving sleep quality early in pregnancy may be important for PTB prevention, particularly among individuals with obesity

Digital rights as a new object of civil rights: Issues of substantive and procedural law

The fourth industrial revolution in the world involving the transition from mechanical and analog electronic technology to digital electronics has a significant impact on the legal systems of all countries of the world, including Russia. Today, relations the subject of which is cryptoactives and relations that related with other objects of the digital world, are becoming more common. Since the legal status of digital objects is not defined in the legislation, these relations are associated with high risks. In this regard new legal acts designed to legalize and regulate new relations were drafted in Russia. Despite many disagreements one of them - «On digital rights» (hereinafter – «Digital rights law») became the law. The decisive significance of this act is seen in the fact that it expands the list of existing objects of civil rights, supplementing it with “digital rights”, which are a legal equivalent of the term “token”. The purpose of this study is to analyze the legal status of “digital rights”, the adequacy and completeness of their legal regulation in the light of the adoption of the new Law. A separate aspect of the study is the identification of procedural problems that may arise in resolving disputes related to digital rights. The key problem is that the legal status of digital rights does not have logical completeness due to the inconsistency in the concept construction of the Digital rights law. In addition, many issues related to the proof of ownership of digital assets, the imposition of a penalty on them, the implementation of liability measures provided for by the Civil Code of the Russian Federation (hereinafter – «Civil Code»), as well as consumer legislation. © Springer Nature Switzerland AG 2020

Digital Rights as a New Object of Civil Rights: Issues of Substantive and Procedural Law

The fourth industrial revolution in the world involving the transition from mechanical and analog electronic technology to digital electronics has a significant impact on the legal systems of all countries of the world, including Russia. Today, relations the subject of which is cryptoactives and relations that related with other objects of the digital world, are becoming more common. Since the legal status of digital objects is not defined in the legislation, these relations are associated with high risks. In this regard new legal acts designed to legalize and regulate new relations were drafted in Russia. Despite many disagreements one of them - «On digital rights» (hereinafter – «Digital rights law») became the law. The decisive significance of this act is seen in the fact that it expands the list of existing objects of civil rights, supplementing it with “digital rights”, which are a legal equivalent of the term “token”. The purpose of this study is to analyze the legal status of “digital rights”, the adequacy and completeness of their legal regulation in the light of the adoption of the new Law. A separate aspect of the study is the identification of procedural problems that may arise in resolving disputes related to digital rights. The key problem is that the legal status of digital rights does not have logical completeness due to the inconsistency in the concept construction of the Digital rights law. In addition, many issues related to the proof of ownership of digital assets, the imposition of a penalty on them, the implementation of liability measures provided for by the Civil Code of the Russian Federation (hereinafter – «Civil Code»), as well as consumer legislation

Fairs and bazaars in the Kazan Province (based on materials from the newspaper “Kazanskie Gubernskie Vedomosti”)

The authors investigate the fairs and bazaars of the Kazan province of the second half of the 19th century in this article which is based on the analysis of the materials of the newspaper "Kazanskie Gubernskiye Vedomosti." Their investigation considers the development of fairs and market trades. In addition to that, they identify the features of the location as well as the functioning of fairs and bazaars. The authors analyze their role as a center of social interaction of different categories residents of the province. The authors concluded that bazaars and fairs had different forms of holding (duration, scale, goods, timing and infrastructure) and were oriented towards different consumers. The bazaars were held weekly and played an important role for the local community, while the fairs were held once a year and were focused on large scale trade and a greater number of visitors, which included other regions. In contrast with the bazaars, the fairs played a more important role in public life in the form of special cultural centers. These venues encouraged interaction of different participating social groups. Fairs and bazaars were perceived by the majority of visitors as a holiday and a desirable form of recreation, which was facilitated by the infrastructure and cultural and entertainment program of these sites

The effect of serum lipids and spermoplasm on the stallion sperm quality

The quality and cryoresistance of stallion sperm depend on many endogenous and exogenous factors. One of the factors affecting the sperm quality are the parameters of the lipid spectrum of spermoplasm and blood serum. Lipase activity, cholesterol and triglyceride content in blood serum and spermoplasm were studied in 19 stallions of the Arabian breed aged from 5 years to 15 years (on average 10.1±0.3 years). It was found that lipase activity in the spermoplasm (217.0 U/l) is on average 11.4 times higher than in the blood serum (19.1 U/l). The concentration of spermoplasm triglycerides (1.3 mmol/l) is on average 4.3 times higher than in blood serum (0.3 mmol/l). The concentration of cholesterol in the blood serum (2.4 mmol/ l) is on average 12 times higher than the same indicator in the stallion spermoplasm (0.2 mmol/l). The relationship between the parameters of the lipid spectrum of blood serum and spermoplasm with the characteristics of stallion sperm was studied. A significant relationship was found between the activity of lipase in blood serum with progressive mobility (r=0.66; p=0.006) and survival (r=0.67; p=0.005) of spermatozoa in cryopreserved sperm

Морфологическое изучение активности матриксных металлопро-теиназ и соотношения коллагена I/III в тканях пародонта в процессе комплексного лечения пациентов с хроническим и агрессивным течением пародонтита

The article presents the results of a follow up morphological study of matrix metalloproteinase activity and collagen type I/III ratio in periodontal tissue of patients with chronic and aggressive periodontitis after conservative and surgical treatment. The results of clinical and morphological studies have shown that the condition of periodontal tissues depends not only on the severity of periodontitis, but also on the nature of the inflammatory process course - chronic or aggressive.В статье представлены результаты морфологического изучения активности матриксных металлопротеиназ и соотношения коллагена I/III в тканях пародонта у пациентов с хроническим и агрессивным течением пародонтита в динамике после проведения консервативного и хирургического лечения. Результаты клинических и морфологических исследований показали, что состояние тканей пародонта зависит не только от степени тяжести пародонтита, но и от характера течения воспалительного процесса - хронического или агрессивного

Recovery process in sponges: morphogenesis and cell sources

2nd workshop of the COST Action 16203 MARISTEM: OMIC APPROACHES TO IDENTIFY AND CHARACTERIZE MARINE/AQUATIC INVERTEBRATE STEM CELLSInternational audienceSponges (Porifera) represent one of the most ancient metazoan lineages. They possess unique anatomical and tissue structure, making them promising models for evolutionary studies. The high plasticity of sponge tissue and cells provide them with outstanding recovery abilities, ranging from wound healing to re-building of a functional body from dissociated cells. We have combined several microscopy techniques to elucidate morphogenesis, cellular mechanisms and cell sources during reparative regeneration and cell reaggregation in five species from different clades: Halisarca dujardinii (Demospongiae), Aplysina cavernicola (Demosponigae), Sycon sp. (Calcarea), 29 Leucosolenia variabilis (Calcarea) and Clathrina arnesenae (Calcarea). The main mechanism of reparative regeneration in studied Demospongiae is cell migrations and epithelio-mesenchymal transformations, involving archaeocytes and choanocytes, which are a cell source for the recovery of lost structures. In contrast, the reparative regeneration in Calcarea occurs due to extensive remodeling of intact tissues near the wound through epithelial morphogenesis, accompanied by cell transdifferentiations. The cell re-aggregation in both Demospongiae and Calcarea involves mass cell dedifferentiation on the early stages of the process. During progressive development of multicellular aggregates, individual cell migrations and transdifferentiations ensure restoration of required cell types and intact anatomical structures. However, epithelial morphogenesis contributes to the development of calcareous sponge aggregates. Thus, during recovery processes, sponges utilize diverse and complex morphogenetic mechanisms, with a particular importance of cell transdifferentiation. While all sponges demonstrate high recovery abilities, the morphogenesis and cell sources for the recovery of lost structures varies in different clades

Effect of ticlopidine on hemostasis in diabetic microangiopathy

[No abstract available

A New Approach to the Assessment of the Safety of Tea, Coffee, Cocoa, and Vegetable Oils, Based on the Rapid Screening of Samples for the Total Concentration of Fluorine-, Chlorine-, and Bromine-Containing Organic Compounds

Abstract: We propose a new approach to assessing the contamination of tea, coffee, cocoa, and vegetable oils with F-, Cl-, Br- and S-containing organic pesticides and other hazardous anthropogenic and natural compounds at a trace level. The approach ensures the rapid screening of test samples for the total concentration of all halogen and sulfur organic compounds present in the samples. Sample preparation is excluded. The procedure is based on the direct high-temperature oxidative conversion of a test sample under oxygen; the absorption of inorganic salts present in the sample in a reactor; the absorption of the conversion products of organic compounds of the sample, including the analyzed ones, by deionized water with the formation of F–, Cl–, Br– and SO42- acccccon in the absorbate by ion chromatography. This approach ensures the simultaneously reliable determination of all volatile, medium-volatile, and nonvolatile organohalogen and organosulfur compounds present in one sample and, thereby, improves the reliability of detection by eliminating their losses during the analysis. © 2021, Pleiades Publishing, Ltd