3 research outputs found
Brain serotonin 4 receptor binding is inversely associated with verbal memory recall
BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5âHT (4)R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5âHT (4)R binding and affective verbal memory recall. METHODS: Twentyâfour healthy volunteers were scanned with the 5âHT (4)R radioligand [(11)C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Testâ24. The association between 5âHT (4)R binding and affective verbal memory was evaluated using a linear latent variable structural equation model. RESULTS: We observed a significant inverse association across all regions between 5âHT (4)R binding and affective verbal memory performances for positive (p = 5.5 Ă 10(â4)) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5âHT (4)R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance. CONCLUSION: Our findings replicate our previous observation of a negative association between 5âHT (4)R binding and memory performance in an independent cohort and provide novel evidence linking 5âHT (4)R binding, as a biomarker for synaptic 5âHT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans
Inter-laboratory mass spectrometry dataset based on passive sampling of drinking water for non-target analysis
Non-target analysis (NTA) employing high-resolution mass spectrometry is a commonly applied approach for the detection of novel chemicals of emerging concern in complex environmental samples. NTA typically results in large and information-rich datasets that require computer aided (ideally automated) strategies for their processing and interpretation. Such strategies do however raise the challenge of reproducibility between and within different processing workflows. An effective strategy to mitigate such problems is the implementation of inter-laboratory studies (ILS) with the aim to evaluate different workflows and agree on harmonized/standardized quality control procedures. Here we present the data generated during such an ILS. This study was organized through the Norman Network and included 21 participants from 11 countries. A set of samples based on the passive sampling of drinking water pre and post treatment was shipped to all the participating laboratories for analysis, using one pre-defined method and one locally (i.e. in-house) developed method. The data generated represents a valuable resource (i.e. benchmark) for future developments of algorithms and workflows for NTA experiments