Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population

Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection.<br/> Methods: A robust new polyclonal-monoclonal solid-phase IRMA for CRP was developed, with a range of 0.05- 10.0 mg/L.<br/> Results: Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25-74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25-64 years) were very similar. The median CRP approximately doubled with age, from similar to 1 mg/L in the youngest decade to similar to 2 mg/L in the oldest, and tended to be higher in females. <br/>Conclusion: This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations

The Case for Comparative Contribution in Florida

This article examines the recently enacted Uniform Contribution Among Tortfeasors Act in Florida. After briefly discussing the common law doctrine of no contribution and efforts to alleviate such a harsh rule, the authors focus on the serious conflicts between the new statute and the underlying equitable principles of Hoffman v. Jones. In particular, the pro rata sharing of liability, the settlement, and the release provisions of the statute are criticized as not allocating the ultimate liability of the tortfeasors based on their relative degrees of fault. The authors suggest that a legislative change regarding these provisions is warranted so as to maintain a consistent and equitable apportionment system for everyone

Holidaying with the family pet: No dogs allowed!

This paper assesses the extent to which dog owners located in Brisbane, Australia, wish to holiday with their pets, and whether there is a gap between this desire and reality. The paper also examines the extent to which this demand is being catered for by the tourism accommodation sector. The need for this study reflects the increasingly significant role dogs are playing in the lives of humans, and the scale of the dog-owning population. The results suggest that, although there is a strong desire among dog owners to take holidays with their pets, the actualisation of this desire is comparatively low. A significant obstacle to the realisation of this desire appears to be a dearth of pet-friendly accommodation. This has implications for the ability of the tourism industry to benefit from this potentially lucrative market, that is, the dog-owning population

On Abelian Multi-Chern-Simons Field Theories

In this paper a class of multi-Chern-Simons field theories which is relevant to the statistical mechanics of polymer systems is investigated. Motivated by the problems which one encounters in the treatment of these theories, a general procedure is presented to eliminate the Chern-Simons fields from their action. In this way it has been possible to derive an expression of the partition function of topologically linked polymers which depends explicitly on the topological numbers and does not have intractable nonlocal terms as it happened in previous approaches. The new formulation of multi-Chern-Simons field theories is then used to remove and clarify some inconsistencies and ambiguities which apparently affect field theoretical models of topologically linked polymers. Finally, the limit of disentangled polymers is discussed.Comment: 18 pages, plain LaTe

Biceps femoris long head morphology in youth competitive alpine skiers is associated with age, biological maturation and traumatic lower extremity injuries

Lower extremity injuries are common in competitive alpine skiers, and the knee and lower leg are often affected. The hamstring muscles, especially the biceps femoris long head (BFlh), can stabilize the knee and the hip and may counteract various adverse loading patterns during typical mechanisms leading to severe lower extremity injuries. The aim of the present study was to describe BFlh morphology in youth competitive alpine skiers in relation to sex, age and biological maturation and to investigate its association with the occurrence of traumatic lower extremity injuries in the upcoming season. 95 youth skiers underwent anthropometric measurements, maturity offset estimations and ultrasound assessment, followed by 12-months prospective injury surveillance. Unpaired t tests showed that the two sexes did not differ in BFlh morphology, including fascicle length (Lf), pennation angle (PA), muscle thickness (MT) and average anatomical cross-sectional area (ACSAavg). In contrast, U16 skiers had longer fascicles than U15 skiers (9.5 ± 1.3 cm vs 8.9 ± 1.3 cm, p < 0.05). Linear regression analyses revealed that maturity offset was associated with Lf (R2 = 0.129, p < 0.001), MT (R2 = 0.244, p < 0.001) and ACSAavg (R2 = 0.065, p = 0.007). No association was found between maturity offset and PA (p = 0.524). According to a binary logistic regression analysis, ACSAavg was significantly associated with the occurrence of traumatic lower extremity injuries (Chi-square = 4.627, p = 0.031, RNagelkerke2 = 0.064, Cohen f = 0.07). The present study showed that BFlh morphology is age- and biological maturation-dependent and that BFlh ACSAavg can be considered a relevant modifiable variable associated with lower extremity injuries in youth competitive alpine skiers

Scanning Electron Microscope Observations of Growth and Ochratoxin - A Production of Aspergillus alutaceus Variety alutaceus (Formerly A. ochraceus) on Gamma-Irradiated Barley

Scanning electron microscope examination, colony counting and biochemical studies were conducted to describe the effect of gammairradiation on growth and ochratoxin A production by Aspergillus alutaceus. Irradiation at a dose of 1.0 or 2.0 kGy reduced the level of mold growth greatly relative to unirradiated controls. Growth in the irradiated samples after 7 to 12 day incubation was mainly in cracks in the hull, and less mycelium was seen on the grain surface. In unirradiated controls, mycelial growth was heavy and, although conidial heads were most abundant in cracks in the hull, they were seen over the whole surface. Vhen the barley was inoculated before irradiation, the number of colony forming units (cfu) at 5 days after 1.0 or 2.0 kGy irradiation was lower than in the unirradiated controls; however, the number increased over the control by 30 days. A dose of 4.0 kGy eliminated viable fungi. Ochratoxin A production decreased from the control level of 17.6 μg/g with increased dose and was below the detection limit above 4.0 kGy. Vhen barley was inoculated after irradiation the spore count and the ochratoxin A level were higher than the unirradiated control after 27 days. We conclude that the difference in growth and ochratoxin A production on irradiated and unirradiated barley is due to the effect of irradiation on the natural competitive microflora on the grain surface and the reduction of inoculum size of the A. alutaceus by radiation

Composition of the Innermost Core Collapse Supernova Ejecta

With presently known input physics and computer simulations in 1D, a self-consistent treatment of core collapse supernovae does not yet lead to successful explosions, while 2D models show some promise. Thus, there are strong indications that the delayed neutrino mechanism works combined with a multi-D convection treatment for unstable layers. On the other hand there is a need to provide correct nucleosynthesis abundances for the progressing field of galactic evolution and observations of low metallicity stars. The innermost ejecta is directly affected by the explosion mechanism, i.e. most strongly the yields of Fe-group nuclei for which an induced piston or thermal bomb treatment will not provide the correct yields because the effect of neutrino interactions is not included. We apply parameterized variations to the neutrino scattering cross sections and alternatively, parameterized variations are applied to the neutrino absorption cross sections on nucleons in the ``gain region''. We find that both measures lead to similar results, causing explosions and a Ye>0.5 in the innermost ejected layers, due to the combined effect of a short weak interaction time scale and a negligible electron degeneracy, unveiling the proton-neutron mass difference. We include all weak interactions (electron and positron capture, beta-decay, neutrino and antineutrino capture on nuclei, and neutrino and antineutrino capture on nucleons) and present first nucleosynthesis results for these innermost ejected layers to discuss how they improve predictions for Fe-group nuclei. The proton-rich environment results in enhanced abundances of 45Sc, 49Ti, and 64Zn as requested by chemical evolution studies and observations of low metallicity stars as well as appreciable production of nuclei in the mass range up to A=80.Comment: 13 pages, 8 figures. Final versio