198 research outputs found
Preliminary study of kaonic deuterium X-rays by the SIDDHARTA experiment at DAFNE
The study of the KbarN system at very low energies plays a key role for the
understanding of the strong interaction between hadrons in the strangeness
sector. At the DAFNE electron-positron collider of Laboratori Nazionali di
Frascati we studied kaonic atoms with Z=1 and Z=2, taking advantage of the
low-energy charged kaons from Phi-mesons decaying nearly at rest. The SIDDHARTA
experiment used X-ray spectroscopy of the kaonic atoms to determine the
transition yields and the strong interaction induced shift and width of the
lowest experimentally accessible level (1s for H and D and 2p for He). Shift
and width are connected to the real and imaginary part of the scattering
length. To disentangle the isospin dependent scattering lengths of the
antikaon-nucleon interaction, measurements of Kp and of Kd are needed. We
report here on an exploratory deuterium measurement, from which a limit for the
yield of the K-series transitions was derived: Y(K_tot)<0.0143 and
Y(K_alpha)<0.0039 (CL 90%). Also, the upcoming SIDDHARTA-2 kaonic deuterium
experiment is introduced.Comment: Accepted by Nuclear Physics
Plasticity in the trophic niche of an invasive ant explains establishment success and long-term coexistence
Which Drug to Discontinue 3 Months After Combination Therapy of Tadalafil plus Tamsulosin for Men with Lower Urinary Tract Symptom and Erectile Dysfunction? Results of a Prospective Observational Trial
Which Drug to Discontinue 3 Months After Combination Therapy of Tadalafil plus Tamsulosin for Men with Lower Urinary Tract Symptom and Erectile Dysfunction? Results of a Prospective Observational Trial
Background: Safety and efficacy of tamsulosin and tadalafil for men with benign prostatic enlargement (BPE) and/or erectile dysfunction (ED) are defined. However, there are only a few pilot studies on combination therapy with these drugs for men with lower urinary tract symptom (LUTS)/BPE and ED. Moreover, preliminary reports are limited to 12 wk, without any information about subsequent therapies. Objective: To evaluate the impact of discontinuation of tamsulosin versus tadalafil 12 wk after combination therapy. Design, setting, and participants: Fifty consecutive patients with moderate-to-severe LUTS (International Prostate Symptom Score [IPSS] > 7) and mild-to-severe ED (International Index of Erectile Function-5 [IIEF-5] < 22) were treated with combination therapy (tamsulosin 0.4 mg/d plus tadalafil 5 mg/d) for 12 wk. After 12 wk, 25 patients discontinued tamsulosin (Group TAD), while 25 patients discontinued tadalafil (Group TAM). Outcome measurements and statistical analysis: Efficacy variables were IPSS (total, voiding, storage) and IIEF-5. Paired samples t test and analysis of variance were used. Results and limitations: Groups TAD and TAM presented similar features (age, BMI, metabolic profile) including symptoms scores at baseline. Similar and significant improvements in IPSS (total, voiding, and storage) and IIEF-5 were recorded in both groups after 12 wk of combination therapy (all p < 0.001). Total IPSS was similar between the two groups at the end of the trial. However, we found between-group significant differences from baseline to 24 wk and from 12 to 24 wk in storage-IPSS (Group TAD: –3.32 vs Group TAM: –1.24, p = 0.002; Group TAD: +0.24 vs Group TAM: +1.20, p = 0.040, respectively) and in IIEF-5 (Group TAD: +4.64 vs Group TAM: +0.16, p < 0.001; Group TAD: –1.64 vs Group TAM: –4.40, p = 0.003). No significant treatment-related adverse event was recorded in both groups. Conclusions: After 12 wk of combination therapy, monotherapy with tadalafil for further 12 wk allows to preserve the improvement of storage IPSS and IIEF-5, in addition to total IPSS. Patient summary: In this report we evaluated the discontinuation of tamsulosin or tadalafil after 12 wk of combination therapy. We found that tadalafil monotherapy, for a further 12 wk, aids in retaining the improvement of storage symptoms and erectile function
Tadalafil 5 mg Alone or in Combination with Tamsulosin 0.4 mg for the Management of Men with Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Prospective Observational Trial.
Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complaining of ED and LUTS were treated for 12-weeks with Tadalafil plus placebo (TAD+PLA-group) or with combination therapy tadalafil plus tamsulosin (TAD+TAM-group). Efficacy variables were: International Index of Erectile Function (IIEF), International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax) and safety assessments. Data were evaluated using paired samples T-test (baseline vs. 12-weeks) and analysis of variance (Δgroup-TAD+PLA vs. Δgroup-TAD+TAM). At baseline, both groups presented similar characteristics and symptoms scores (all: p > 0.05). From baseline to 12-weeks, all the subjects showed a significant improvement of IIEF, total-IPSS, storage-IPSS, Qmax (all: p < 0.001). Conversely, a significant improvement of voiding-IPSS was observed in TAD+TAM-group (−3.5 points, p < 0.001). Indeed, TAD+PLA-group showed a not significant improvement of voiding-IPSS (−2.0 points, p = 0.074). When we compared between-groups differences at 12-weeks, IIEF (p = 0.255), total-IPSS (p = 0.084) and storage-IPSS (p = 0.08) did not show any statistically significant differences, whereas, voiding-IPSS and Qmax were significantly better in TAD+TAM-group (p = 0.006 and p = 0.027, respectively). No severe treatment adverse events (TAEs) were reported in both groups. Tadalafil achieved the same improvements of IIEF, total-IPSS, storage-IPSS when compared to combination therapy. Instead, Qmax and voiding-IPSS were better managed with combination therapy, without change of TAEs
First measurement of kaonic helium-3 X-rays
The first observation of the kaonic 3He 3d - 2p transition was made using
slow K- mesons stopped in a gaseous 3He target. The kaonic atom X-rays were
detected with large-area silicon drift detectors using the timing information
of the K+K- pairs of phi-meson decays produced by the DAFNE e+e- collider. The
strong interaction shift of the kaonic 3He 2p state was determined to be -2+-2
(stat)+-4 (syst) eV.Comment: Accepted for publication in Phys. Lett.
A New Measurement of Kaonic Hydrogen X rays
The system at threshold is a sensitive testing ground for low
energy QCD, especially for the explicit chiral symmetry breaking. Therefore, we
have measured the -series x rays of kaonic hydrogen atoms at the DANE
electron-positron collider of Laboratori Nazionali di Frascati, and have
determined the most precise values of the strong-interaction energy-level shift
and width of the atomic state. As x-ray detectors, we used large-area
silicon drift detectors having excellent energy and timing resolution, which
were developed especially for the SIDDHARTA experiment. The shift and width
were determined to be eV and
eV, respectively. The new
values will provide vital constraints on the theoretical description of the
low-energy interaction.Comment: 5 figures, submitted to Physics Letters
Unlocking the secrets of the kaon-nucleon/nuclei interactions at low-energies: The SIDDHARTA(-2) and the AMADEUS experiments at the DA Phi NE collider
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Kaonic hydrogen X-ray measurement in SIDDHARTA
Kaonic hydrogen atoms provide a unique laboratory to probe the kaon-nucleon
strong interaction at the energy threshold, allowing an investigation of the
interplay between spontaneous and explicit chiral symmetry breaking in
low-energy QCD. The SIDDHARTA Collaboration has measured the -series X rays
of kaonic hydrogen atoms at the DANE electron-positron collider of
Laboratori Nazionali di Frascati, and has determined the most precise values of
the strong-interaction induced shift and width of the atomic energy level.
This result provides vital constraints on the theoretical description of the
low-energy interaction.Comment: 11 pages, 7 figures, Nuclear Physics A (in press) Special Issue on
Strangeness Nuclear Physic
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