On Languages Accepted by P/T Systems Composed of joins

Recently, some studies linked the computational power of abstract computing systems based on multiset rewriting to models of Petri nets and the computation power of these nets to their topology. In turn, the computational power of these abstract computing devices can be understood by just looking at their topology, that is, information flow. Here we continue this line of research introducing J languages and proving that they can be accepted by place/transition systems whose underlying net is composed only of joins. Moreover, we investigate how J languages relate to other families of formal languages. In particular, we show that every J language can be accepted by a log n space-bounded non-deterministic Turing machine with a one-way read-only input. We also show that every J language has a semilinear Parikh map and that J languages and context-free languages (CFLs) are incomparable

Synthesis of novel structural hybrids between aza-heterocycles and azelaic acid moiety with a specific activity on osteosarcoma cells

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (HDACi). The azelayl moiety recalls part of 9-hydroxystearic acid, a cellular lipid showing antiproliferative activity toward cancer cells with HDAC as a molecular target. Azelayl derivatives bound to a benzothiazolyl moiety further proved to be active as HDACi. The novel compounds were tested on a panel of both normal and tumor cell lines. Non-specific induction of cytotoxicity was observed in the normal cell line, while three of them induced a biological effect only on the osteosarcoma (U2OS) cell line. One of them induced a change in nuclear shape and size. Cell-cycle alterations are associated with post-transcriptional modification of both H2/H3 and H4 histones. In line with recent studies, revealing unexpected HDAC7 function in osteoclasts, molecular docking studies on the active molecules predicted their proneness to interact with HDAC7. By reducing side effects associated with the action of the first-generation inhibitors, the herein reported compounds, thus, sound promising as selective HDACi

Using Public Landslide Inventories for Landslide Susceptibility Assessment at the Basin Scale: Application to the Torto River Basin (Central-Northern Sicily, Italy)

In statistical landslide susceptibility evaluation, the quality of the model and its prediction image heavily depends on the quality of the landslide inventories used for calibration. However, regional-scale inventories made available by public territorial administrations are typically affected by an unknown grade of incompleteness and mapping inaccuracy. In this research, a procedure is proposed for verifying and solving such limits by applying a two-step susceptibility modeling procedure. In the Torto River basin (central-northern Sicily, Italy), using an available regional landslide inventory (267 slide and 78 flow cases), two SUFRA_1 models were first prepared and used to assign a landslide susceptibility level to each slope unit (SLU) in which the study area was partitioned. For each of the four susceptibility classes that were obtained, 30% of the mapping units were randomly selected and their stable/unstable status was checked by remote analysis. The new, increased inventories were finally used to recalibrate two SUFRA_2 models. The prediction skills of the SUFRA_1 and SUFRA_2 models were then compared by testing their accuracy in matching landslide distribution in a test sub-basin where a high-resolution systematic inventory had been prepared. According to the results, the strong limits of the SUFRA_1 models (sensitivity: 0.67 and 0.57 for slide and flow, respectively) were largely solved by the SUFRA_2 model (sensitivity: 1 for both slide and flow), suggesting the proposed procedure as a possibly suitable modeling strategy for regional susceptibility studies

What Makes Russian Women (Un)Happy? A Closer Look at the Family

Two decades of economic transition revealed that Russian women are on average less happy than men. This paper addresses individual subjective well-being from the intra-family perspective and investigates whether the gender satisfaction gap could be caused, among all, by a mismatch between the socially imposed patriarchal family gender roles and the actually performed ones. I test for the presence of the following phenomena: (1) a fair share of income brought by each of the spouses into their household is judged according to the patriarchal model attributing the role of the breadwinner to men; (2) division of housework, with women, even if working, holding the main responsibility for housekeeping activities, is perceived as fair. Prime-age working adults living in partnership constitute the dataset which is a part of the Russian Longitudinal Monitoring Survey for 1994-2004. Life satisfaction is modelled with the help of the seemingly unrelated bivariate ordered probit model aiming at the adjustment for unobserved factors influencing happiness evaluation of both partners. For the period 1994-1998, the results show that women's relative unhappiness is likely to be causes by their increasing earning powers with relative to men, and overload with hours spent on housekeeping in households with children. In the second period of economic growth, 2000 - 2004, I observe a change in women's preferences over time-use and total income shares, suggesting a tendency towards their emancipation

Are Women Happier When Their Spouse is Teleworker?

© 2017 Springer Science+Business Media Dordrecht. This study explores the household production allocation and happiness of women when their spouse is teleworker using data from the British Household Panel Survey over the years 1991–2009. The study aims to answer whether the women spend additional time on housework and are happier when they or their partner is teleworker. Also, we explore whether are happier when they share the household–domestic production with their partners. Fixed effects estimates take place, and we consider a Bayesian Network framework and a directed acyclic graph for causal inference. The results show that women are more likely to state that the household allocation, such as cooking, cleaning, ironing and childcare is shared when their partner teleworks. Shopping is an exception which can be regarded as an outdoor activity while one partner may be mainly responsible for this chore. In addition, women are happier when they or their spouse is teleworker, and they report higher levels of happiness when the household production allocation is a shared process. This may indicate men teleworkers may contribute extra to the household production releasing a burden for the partners and improving their well-being