Fourth Ventricular Schwannoma: Identical Clinicopathologic Features as Schwann Cell-Derived Schwannoma with Unique Etiopathologic Origins

Background. To our knowledge, this is the sixth reported case in the literature of fourth ventricular schwannoma. The etiology and natural history of intraventricular schwannomas is not well understood. A thorough review of potential etiopathogenic mechanisms is provided in this case report. Case Description. A 69-year-old man presented with an incidentally found fourth ventricular tumor during an evaluation for generalized weakness, gait instability, and memory disturbance. Magnetic resonance imaging (MRI) revealed a heterogeneously enhancing lesion in the fourth ventricle. A suboccipital craniotomy was performed to resect the lesion. Histopathological examination confirmed the diagnosis of schwannoma (WHO grade I). Conclusions. Schwannomas should be considered in the differential diagnosis of intraventricular tumors. Although the embryologic origins may be different from nerve sheath-derived schwannomas, the histologic, clinical, and natural history appear identical and thus should be managed similarly

The Grizzly, March 29, 2007

Re-opening of Bomberger Hall • Incite AAAS Program Debut Newsletter • Young Girl\u27s Death Sparks Ethics Debate • Professor Vosburgh Awaits Trial • The Burning Question • Beat It! • Ursinus Theater Hosting Musical Farce • Mr. Ursinus Crowned • Nutrition Tips: Alcohol\u27s Caloric Content • Opinions: Injustice in Justice • Rangers Upset Ursinus with Last Second Goalhttps://digitalcommons.ursinus.edu/grizzlynews/1735/thumbnail.jp

The Grizzly, April 19, 2007

Airband a Success • Omega Chi Blood Drive • Hillel Holocaust Discussion • Letter to the Editor • What Dreams May Come • Ivory-billed Woodpecker Not Extinct! • Fiber Facts • Earth-Shattering Drumming • Opinions: No Child Left Behind? Really?; Gitmo on Strike • Bears Win 11th in a Row; Coach McGowan Earns 200th Victory • Women\u27s Lacrosse Hangs Tough with #4 Gettysburghttps://digitalcommons.ursinus.edu/grizzlynews/1738/thumbnail.jp

The Grizzly, March 1, 2007

Media Lecture: The Jailhouse Doesn\u27t Rock • Peanut Butter Recall Update • Annual UC Job and Internship Fair • Living in Sin • Creating Communication Elation • Spotlight on Coach Kevin Small • Laramie Hits Big at Ursinus • Nutrition Tips: Fad Diets • Opinions: English as the Official Language? • Bears Capture Centennial Conference Title • Men\u27s Lacrosse Season Previewhttps://digitalcommons.ursinus.edu/grizzlynews/1733/thumbnail.jp

The Grizzly, February 15, 2007

Darfur Fast Week Kickoff • United Men of Color Reception • The Peter Pan Project • CoSA Kickoff a Success • Power of Purple • Preview of The Laramie Project • Nutrition Tips • Inside Look at New Member Education • Opinions: Black History Month; Our Long-Awaited Greek Column • Heartbreak at Hopkins • Guntli Leading Rebounder • Senior Day Basketball Double-Headerhttps://digitalcommons.ursinus.edu/grizzlynews/1731/thumbnail.jp

The Grizzly, April 12, 2007

Project Pericles Continues to Succeed in Community Service • Macs Lag in Environmental Friendliness According to Greenpeace • New Dorm Progress • Ursinus Freshmen Fall Behind in Collegiate Learning Assessment • Spread Your Legs and Turn Your Head and Cough • Relay for Life Fast Approaching • Ursinus, Break the Silence! • Nutrition Tips: Veggie Report • Opinions: Dear Mahmoud • Bears Terrorize McDaniel, Sit Atop CC Standings • Bears Finish Second at NCGA Championshipshttps://digitalcommons.ursinus.edu/grizzlynews/1737/thumbnail.jp

The Grizzly, February 1, 2007

New Ellen Priest Exhibit at the Berman • What\u27s Going on with Exposure? • Uterus Transplants Could Give Women Another Chance • What is Kaplan? • Study Abroad • Am I Ready to Have Sex? • Students Raise Awareness One Arabian Night • Nutrition Tips for the UC Student • UC to Host Relay for Life Again This Spring • Opinions: On the State of the Union Address; Ever-Changing 2008 Election • Swim Sorrows • Bears\u27 Basketball in Postseason Hunthttps://digitalcommons.ursinus.edu/grizzlynews/1729/thumbnail.jp

Reduced Body Weight and Increased Energy Expenditure in Transgenic Mice Over-Expressing Soluble Leptin Receptor

studies have shown that OBRe expression is inversely correlated to body weight and leptin levels. However, it is not clear whether OBRe plays an active role, either in collaboration with leptin or independently, in the maintenance of body weight.To investigate the function of OBRe in the regulation of energy homeostasis, we generated transgenic mice that express OBRe under the control of human serum amyloid P (hSAP) component gene promoter. The transgene led to approximately doubling of OBRe in circulation in the transgenic mice than in wild type control mice. Transgenic mice exhibited lower body weight at 4 weeks of age, and slower rate of weight gain when compared with control mice. Furthermore, transgenic mice had lower body fat content. Indirect calorimetry revealed that transgenic mice had reduced food intake, increased basal metabolic rate, and increased lipid oxidation, which could account for the differences in body weight and body fat content. Transgenic mice also showed higher total circulating leptin, with the majority of it being in the bound form, while the amount of free leptin is comparable between transgenic and control mice.These results are consistent with the role of OBRe as a leptin binding protein in regulating leptin's bioavailability and activity