533 research outputs found
Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: A multicenter retrospective study
A Variational Principle Based Study of KPP Minimal Front Speeds in Random Shears
Variational principle for Kolmogorov-Petrovsky-Piskunov (KPP) minimal front
speeds provides an efficient tool for statistical speed analysis, as well as a
fast and accurate method for speed computation. A variational principle based
analysis is carried out on the ensemble of KPP speeds through spatially
stationary random shear flows inside infinite channel domains. In the regime of
small root mean square (rms) shear amplitude, the enhancement of the ensemble
averaged KPP front speeds is proved to obey the quadratic law under certain
shear moment conditions. Similarly, in the large rms amplitude regime, the
enhancement follows the linear law. In particular, both laws hold for the
Ornstein-Uhlenbeck process in case of two dimensional channels. An asymptotic
ensemble averaged speed formula is derived in the small rms regime and is
explicit in case of the Ornstein-Uhlenbeck process of the shear. Variational
principle based computation agrees with these analytical findings, and allows
further study on the speed enhancement distributions as well as the dependence
of enhancement on the shear covariance. Direct simulations in the small rms
regime suggest quadratic speed enhancement law for non-KPP nonlinearities.Comment: 28 pages, 14 figures update: fixed typos, refined estimates in
section
Real-time in vivo Cherenkoscopy Imaging During External Beam Radiation Therapy
Cherenkov radiation is induced when charged particles travel through dielectric media (such as biological tissue) faster than the speed of light through that medium. Detection of this radiation or excited luminescence during megavoltage external beam radiotherapy (EBRT) can allow emergence of a new approach to superficial dose estimation, functional imaging, and quality assurance for radiation therapy dosimetry. In this letter, the first in vivo Cherenkov images of a real-time Cherenkoscopy during EBRT are presented. The imaging system consisted of a time-gated intensified charge coupled device (ICCD) coupled with a commercial lens. The ICCD was synchronized to the linear accelerator to detect Cherenkov photons only during the 3.25-μs radiation bursts. Images of a tissue phantom under irradiation show that the intensity of Cherenkov emission is directly proportional to radiation dose, and images can be acquired at 4.7 frames/s with SNR\u3c30 . Cherenkoscopy was obtained from the superficial regions of a canine oral tumor during planned, Institutional Animal Care and Use Committee approved, conventional (therapeutically appropriate) EBRT irradiation. Coregistration between photography and Cherenkoscopy validated that Cherenkov photons were detected from the planned treatment region. Real-time images correctly monitored the beam field changes corresponding to the planned dynamic wedge movement, with accurate extent of overall beam field, and expected cold and hot regions
Uniform random generation of large acyclic digraphs
Directed acyclic graphs are the basic representation of the structure
underlying Bayesian networks, which represent multivariate probability
distributions. In many practical applications, such as the reverse engineering
of gene regulatory networks, not only the estimation of model parameters but
the reconstruction of the structure itself is of great interest. As well as for
the assessment of different structure learning algorithms in simulation
studies, a uniform sample from the space of directed acyclic graphs is required
to evaluate the prevalence of certain structural features. Here we analyse how
to sample acyclic digraphs uniformly at random through recursive enumeration,
an approach previously thought too computationally involved. Based on
complexity considerations, we discuss in particular how the enumeration
directly provides an exact method, which avoids the convergence issues of the
alternative Markov chain methods and is actually computationally much faster.
The limiting behaviour of the distribution of acyclic digraphs then allows us
to sample arbitrarily large graphs. Building on the ideas of recursive
enumeration based sampling we also introduce a novel hybrid Markov chain with
much faster convergence than current alternatives while still being easy to
adapt to various restrictions. Finally we discuss how to include such
restrictions in the combinatorial enumeration and the new hybrid Markov chain
method for efficient uniform sampling of the corresponding graphs.Comment: 15 pages, 2 figures. To appear in Statistics and Computin
The Secret to Successful User Communities: An Analysis of Computer Associates’ User Groups
This paper provides the first large scale study that examines the impact of both individual- and group-specific factors on the benefits users obtain from their user communities. By empirically analysing 924 survey responses from individuals in 161 Computer Associates' user groups, this paper aims to identify the determinants of successful user communities. To measure success, the amount of time individual members save through having access to their user networks is used. As firms can significantly profit from successful user communities, this study proposes four key implications of the empirical results for the management of user communities
Emergent Geometry and Gravity from Matrix Models: an Introduction
A introductory review to emergent noncommutative gravity within Yang-Mills
Matrix models is presented. Space-time is described as a noncommutative brane
solution of the matrix model, i.e. as submanifold of \R^D. Fields and matter on
the brane arise as fluctuations of the bosonic resp. fermionic matrices around
such a background, and couple to an effective metric interpreted in terms of
gravity. Suitable tools are provided for the description of the effective
geometry in the semi-classical limit. The relation to noncommutative gauge
theory and the role of UV/IR mixing is explained. Several types of geometries
are identified, in particular "harmonic" and "Einstein" type of solutions. The
physics of the harmonic branch is discussed in some detail, emphasizing the
non-standard role of vacuum energy. This may provide new approach to some of
the big puzzles in this context. The IKKT model with D=10 and close relatives
are singled out as promising candidates for a quantum theory of fundamental
interactions including gravity.Comment: Invited topical review for Classical and Quantum Gravity. 57 pages, 5
figures. V2,V3: minor corrections and improvements. V4,V5: some improvements,
refs adde
Constraint-based probabilistic learning of metabolic pathways from tomato volatiles
Clustering and correlation analysis techniques have become popular tools for the analysis of data produced by metabolomics experiments. The results obtained from these approaches provide an overview of the interactions between objects of interest. Often in these experiments, one is more interested in information about the nature of these relationships, e.g., cause-effect relationships, than in the actual strength of the interactions. Finding such relationships is of crucial importance as most biological processes can only be understood in this way. Bayesian networks allow representation of these cause-effect relationships among variables of interest in terms of whether and how they influence each other given that a third, possibly empty, group of variables is known. This technique also allows the incorporation of prior knowledge as established from the literature or from biologists. The representation as a directed graph of these relationship is highly intuitive and helps to understand these processes. This paper describes how constraint-based Bayesian networks can be applied to metabolomics data and can be used to uncover the important pathways which play a significant role in the ripening of fresh tomatoes. We also show here how this methods of reconstructing pathways is intuitive and performs better than classical techniques. Methods for learning Bayesian network models are powerful tools for the analysis of data of the magnitude as generated by metabolomics experiments. It allows one to model cause-effect relationships and helps in understanding the underlying processes
Robotic nephrolithotomy and pyelolithotomy with utilization of the robotic ultrasound probe
MAGE I Transcription Factors Regulate KAP1 and KRAB Domain Zinc Finger Transcription Factor Mediated Gene Repression
Class I MAGE proteins (MAGE I) are normally expressed only in developing germ cells but are aberrantly expressed in many cancers. They have been shown to promote tumor survival, aggressive growth, and chemoresistance but the underlying mechanisms and MAGE I functions have not been fully elucidated. KRAB domain zinc finger transcription factors (KZNFs) are the largest group of vertebrate transcription factors and regulate neoplastic transformation, tumor suppression, cellular proliferation, and apoptosis. KZNFs bind the KAP1 protein and direct KAP1 to specific DNA sequences where it suppresses gene expression by inducing localized heterochromatin characterized by histone 3 lysine 9 trimethylation (H3me3K9). Discovery that MAGE I proteins also bind to KAP1 prompted us to investigate whether MAGE I can affect KZNF and KAP1 mediated gene regulation. We found that expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382, a KZNF with tumor suppressor activity. ChIP of MAGE I (-) HEK293T cells showed KAP1 and H3me3K9 are normally bound to the ID1 gene, a target of ZNF382, but that binding is greatly reduced in the presence of MAGE I proteins. MAGE I expression relieved KAP1 mediated ID1 repression, causing increased expression of ID1 mRNA and ID1 chromatin relaxation characterized by loss of H3me3K9. MAGE I binding to KAP1 also induced ZNF382 poly-ubiquitination and degradation, consistent with loss of ZNF382 leading to decreased KAP1 binding to ID1. In contrast, MAGE I expression caused increased KAP1 binding to Ki67, another KAP1 target gene, with increased H3me3K9 and decreased Ki67 mRNA expression. Since KZNFs are required to direct KAP1 to specific genes, these results show that MAGE I proteins can differentially regulate members of the KZNF family and KAP1 mediated gene repression
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