Design Requirements for AI-based Services Enriching Legacy Information Systems in Enterprises: A Managerial Perspective

Information systems (IS) have been introduced in enterprises for decades to generate business value. Historically systems that are deeply integrated into business processes and not replaced remain vital assets, and thus become legacy IS (LISs). To secure the future success, enterprises invest in innovative technologies such as artificial intelligence-based services (AIBSs), enriching LISs and assisting employees in the execution of work-related tasks. This study develops design requirements from a managerial perspective by following a mixed-method approach. First, we conducted ten interviews to formulate requirements to design AIBSs. Second, we evaluated their business value using an online survey (N = 101). The results indicate that executives consider design requirements as relevant that create strategic advancements in the short term. With the help of our findings, researchers can better understand where further in-depth studies are needed to refine the requirements. Practitioners can learn how AIBSs generate business value when enriching LISs

Towards Successful Collaboration: Design Guidelines for AI-based Services enriching Information Systems in Organisations

Information systems (IS) are widely used in organisations to improve business performance. The steady progression in improving technologies like artificial intelligence (AI) and the need of securing future success of organisations lead to new requirements for IS. This research in progress firstly introduces the term AI-based services (AIBS) describing AI as a component enriching IS aiming at collaborating with employees and assisting in the execution of work-related tasks. The study derives requirements from ten expert interviews to successful design AIBS following Design Science Research (DSR). For a successful deployment of AIBS in organisations the D&M IS Success Model will be considered to validated requirements within three major dimensions of quality: Information Quality, System Quality, and Service Quality. Amongst others, preliminary findings propose that AIBS must be preferably authentic. Further discussion and research on AIBS is forced, thus, providing first insights on the deployment of AIBS in organisations

Understanding Collaboration with Virtual Assistants—The Role of Social Identity and the Extended Self

Organizations introduce virtual assistants (VAs) to support employees with work-related tasks. VAs can increase the success of teamwork and thus become an integral part of the daily work life. However, the effect of VAs on virtual teams remains unclear. While social identity theory describes the identification of employees with team members and the continued existence of a group identity, the concept of the extended self refers to the incorporation of possessions into one’s sense of self. This raises the question of which approach applies to VAs as teammates. The article extends the IS literature by examining the impact of VAs on individuals and teams and updates the knowledge on social identity and the extended self by deploying VAs in a collaborative setting. Using a laboratory experiment with N = 50, two groups were compared in solving a task, where one group was assisted by a VA, while the other was supported by a person. Results highlight that employees who identify VAs as part of their extended self are more likely to identify with team members and vice versa. The two aspects are thus combined into the proposed construct of virtually extended identification explaining the relationships of collaboration with VAs. This study contributes to the understanding on the influence of the extended self and social identity on collaboration with VAs. Practitioners are able to assess how VAs improve collaboration and teamwork in mixed teams in organizations

Targeting Antibiotics to Households for Trachoma Control

Repeated ocular infection with the bacterium Chlamydia trachomatis leads to the development of trachoma, a major cause of infectious blindness worldwide. Mass distribution of antibiotics, a component of the current trachoma control strategy, has had success in reducing infection in some areas, but results in a large number of uninfected people receiving antibiotics. We have previously shown that transmission of the bacteria between people in the same household is very efficient. Here, we investigated the effectiveness and cost-effectiveness of targeting antibiotics to households with active trachoma (inflammatory disease) compared to mass distribution, using data from four trachoma-endemic populations and a mathematical model of transmission. We found a high correspondence between households with active trachoma and infected households. In all populations the household targeted approach was predicted to be as effective as mass distribution, but it reduced the number of uninfected individuals receiving antibiotics, making the targeted strategy more cost-effective when antibiotics are not donated. Assuming antibiotics are donated, we predicted the targeted strategy to be more cost effective if it increases the proportion of infected individuals receiving treatment. Further work to address the feasibility and the cost variability in implementing the targeted approach in different settings is now required

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis

The heterotrimeric G-protein complex is minimally composed of Ga, Gb, and Gc subunits. In the classic scenario, the G-protein complex is the nexus in signaling from the plasma membrane, where the heterotrimeric G-protein associates with heptahelical G-protein-coupled receptors (GPCRs), to cytoplasmic target proteins called effectors. Although a number of effectors are known in metazoans and fungi, none of these are predicted to exist in their canonical forms in plants. To identify ab initio plant G-protein effectors and scaffold proteins, we screened a set of proteins from the G-protein complex using two-hybrid complementation in yeast. After deep and exhaustive interrogation, we detected 544 interactions between 434 proteins, of which 68 highly interconnected proteins form the core G-protein interactome. Within this core, over half of the interactions comprising two-thirds of the nodes were retested and validated as genuine in planta. Co-expression analysis in combination with phenotyping of loss-of-function mutations in a set of core interactome genes revealed a novel role for G-proteins in regulating cell wall modification