On Vague Computers

Vagueness is something everyone is familiar with. In fact, most people think that vagueness is closely related to language and exists only there. However, vagueness is a property of the physical world. Quantum computers harness superposition and entanglement to perform their computational tasks. Both superposition and entanglement are vague processes. Thus quantum computers, which process exact data without "exploiting" vagueness, are actually vague computers

Three-dimensional hydrodynamic and sediment transport modeling to test the sediment focusing hypothesis in upland lakes

Palaeolimnological studies rely on assumptions regarding the distribution and completeness of lake deposits that are not always fully supported by observations. In particular, the assumption that “focusing” of suspended sediments leads to preferential deposition in the deepest part of a lake is not always justified, especially in upland lakes subject to energetic wind forcing. Few studies have investigated the hydrodynamic controls on lake sediment focusing, especially the importance of wind-driven currents in deep water. We combine a three-dimensional numerical hydrodynamic and suspended sediment model (FVCOM) with a semi-empirical wind wave model to investigate the potential mobility of bottom sediments in a small oligotrophic upland lake (Llyn Conwy, north Wales, UK). Exploratory simulations of wave- and current-generated bottom stress and suspended sediment dynamics confirm the expected importance of wave-generated bottom stresses in shallower waters (< 3 m depth) around the shore. Field survey shows that lake sediments are largely absent from this zone. This is consistent with peripheral wave action as a sediment focusing mechanism. In deeper water, wind-driven currents become the dominant contributor to bottom stress. Strong wind forcing events drive an energetic circulation with peak bottom stresses that intermittently exceed any realistic erosion threshold over a large proportion of the lake at depths far below those at which waves can be effective. The spatial distribution of lake sediments, and the completeness of the sediment record, is thus determined by a complex interaction between wind-driven circulation and bathymetry, rather than by bathymetry alone. Although our sediment dynamics simulations are purely exploratory, the results are consisted with survey results that show a patchy distribution of deep-water accumulation. Some implications of these results for the selection of sediment coring locations and the interpretation of sediment records are considered

Comparison of Binax NOW urine antigen test and pneumococcal DNA assay using qPCR before and after nasopharyngeal swabbing in healthy Malawian children.

Diagnosis of invasive pneumococcal disease is challenging. We compared Binax NOW pneumococcal urinary antigen test with blood pneumococcal PCR in healthy Malawian children with and without pneumococcal carriage, and we found a high false-positive rate with Binax NOW. Blood pneumococcal PCR positivity was 66/88 (75%) compared to 5/27 (18%) when nasopharyngeal swabbing was performed first compared to after blood sampling for pneumococcal blood PCR. We speculate that nasopharyngeal swabbing may be causing a breach of mucosal integrity, leading to invasion into the bloodstream. These findings need to be confirmed with autolysin-based PCR assays

Improved Depth Recovery In Consumer Depth Cameras via Disparity Space Fusion within Cross-spectral Stereo

We address the issue of improving depth coverage in consumer depth cameras based on the combined use of cross-spectral stereo and near infra-red structured light sensing. Specifically we show that fusion of disparity over these modalities, within the disparity space image, prior to disparity optimization facilitates the recovery of scene depth information in regions where structured light sensing fails. We show that this joint approach, leveraging disparity information from both structured light and cross-spectral sensing, facilitates the joint recovery of global scene depth comprising both texture-less object depth, where conventional stereo otherwise fails, and highly reflective object depth, where structured light (and similar) active sensing commonly fails. The proposed solution is illustrated using dense gradient feature matching and shown to outperform prior approaches that use late-stage fused cross-spectral stereo depth as a facet of improved sensing for consumer depth cameras

Implementation of a 3D ocean model to understand upland lake wind-driven circulation

A community numerical ocean model is used to extend the understanding of wind-driven circulation in small upland lakes. A 3D model of a case study lake (Llyn Conwy, Wales, UK) is calibrated against measured velocity profiles via adjustment of the bottom roughness coefficient. Validation against a separate set of measured velocity profiles confirms the ability of the model to resolve key features of the flow field. Sensitivity analysis shows that the velocity field responds rapidly to changes in the wind forcing. Analysis of the gross circulation using Empirical Orthogonal Functions reveals a persistent two-gyre circulation pattern in the upper half layer of the water column driven by the interaction of wind and bathymetry. At the bottom, the flow is characterised by locally strong currents and analysis of vertical circulation over short time scales shows strong currents in the deepest parts of the lake basin and the responsiveness of the water column to changes in wind speed and direction. Even in small lakes, the assumption of uniform wind stress across the water surface is not always justified and topographic sheltering or other catchment roughness effects give rise to heterogeneity in the wind field. An idealized experiment for the case study lake shows that differences in circulation emerge if the wind stress is allowed to vary across the lake. Energetic wind forcing in upland areas can drive an energetic lake circulation that has important implications for mixing and sediment dynamics. 3D numerical modelling of wind-driven circulation should be more widely used to provide insights into physical limnology to support a wide range of ecological, biogeochemical and palaeoenvironmental studies

Mathematical modeling of the metastatic process

Mathematical modeling in cancer has been growing in popularity and impact since its inception in 1932. The first theoretical mathematical modeling in cancer research was focused on understanding tumor growth laws and has grown to include the competition between healthy and normal tissue, carcinogenesis, therapy and metastasis. It is the latter topic, metastasis, on which we will focus this short review, specifically discussing various computational and mathematical models of different portions of the metastatic process, including: the emergence of the metastatic phenotype, the timing and size distribution of metastases, the factors that influence the dormancy of micrometastases and patterns of spread from a given primary tumor.Comment: 24 pages, 6 figures, Revie

Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels

Myxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs. It varies from dogs without clinical signs to those developing left-sided congestive heart failure, leading to death. Cavalier King Charles Spaniels (CKCSs) are particularly susceptible to MMVD. We hypothesised that within the elderly CKCS population, there is a sub-cohort of MMVD-affected dogs that do not have cardiac remodelling. The objectives of the present study were (i) to determine the prevalence and the degree of cardiac remodelling associated with MMVD; and (ii) assess the effect of age, gender, and body weight on echocardiographic status in a population of aged CKCSs. A total of 126 CKCSs ≥ 8 years old were prospectively included. They all had a physical and echocardiographic examination. A systolic murmur was detected in 89% of dogs; the presence of clinical signs was reported in 19% of them; and echocardiographic evidence of MMVD was described in 100%. Despite the high prevalence, 44.4% of the dogs were clear of echocardiographic signs of cardiac remodelling. Age was significantly associated with the presence and severity of cardiac remodelling and mitral valve prolapse. Our results showed that a proportion of elderly CKCS with confirmed MMVD did not undergo advanced stages of this pathology.This research was funded by the British CKCS Breed Club and The Roslin Institute, University of Edinburgh

Eliza Haywoods geschichte des fräuleins Elisabeth Thoughtless (1756): frühe selbsterkenntnis und ehekritik in der englischen ubersetzungsliteratur

Die Tradition, Frauenerleben aus weiblicher Perspektive zum Mittelpunkt eines Romans zu machen, beginnt in Deutschland nicht mit Sophie La Roches Geschichte des Fräuleins von Sternheim (1771), sondern mit den Werken englischer Schriftstellerinnen, die bereits bedeutend früher in deutschen Übersetzungen erschienen und bisher von der Germanistik nicht beachtet worden sind. An Eliza Haywoods Geschichte des Fräuleins Elisabeth Thoughtless (1756) soll hier exemplarisch gezeigt werden, wie in Deutschland Mitte des 18. Jahrhunderts bereits eine Form der Literatur von Frauen erscheint, die die Entwicklung eines weiblichen Charakters zum Mittelpunkt hat. Obwohl der Übersetzer die in diesem Roman enthaltene Kritik an der patriarchalisch geführten Ehe und der Idealisierung der Frau durch eine bewusst gewählte Übersetzungsstrategie abschwächt, um der Leserschaft den für deutsche Verhältnisse zu radikalen Text angenehmer zu machen, ist dieser, von Lessing als das Werk eines Genies bewertete Roman ein Meilenstein in der Literatur von Frauen