3 research outputs found
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
- Author
- Aban M
- Abeyskera KWM
- Aboagye J
- Adam M
- Adams K
- Adamson JP
- Adewatan G
- Adlou S
- Ahmed K
- Akhalwaya S
- Akhalwaya Y
- Alcock A
- Aley PK
- Ali A
- Allen ER
- Allen L
- Alvernaz FB
- Amorim FS
- Andrade CS
- Andritsou F
- Angus B
- Anslow R
- Arbe-Barnes EH
- Ariaans MP
- Arns B
- Arruda L
- Assad L
- Azi LDA
- Azi PDA
- Babbage G
- Bailey C
- Baillie VL
- Baker KF
- Baker M
- Baker N
- Baker P
- Baleanu I
- Bandeira D
- Bara A
- Barbosa MAS
- Barker D
- Barlow GD
- Barnabas SL
- Barnes E
- Barr AS
- Barrett J
- Barrett JR
- Barrett K
- Bates L
- Batten A
- Beadon K
- Beales E
- Beckley R
- Belij-Rammerstorfer S
- Bell J
- Bellamy D
- Belton S
- Berg A
- Bermejo L
- Berrie E
- Berry L
- Berzenyi D
- Beveridge A
- Bewley KR
- Bharaj I
- Bhikha S
- Bhorat AE
- Bhorat QE
- Bhorat ZE
- Bibi S
- Bijker EM
- Birch G
- Birch S
- Birchall K
- Bird A
- Bird O
- Bisnauthsing K
- Bittaye M
- Blackwell L
- Blacow R
- Bletchly H
- Blundell CL
- Blundell SR
- Bodalia P
- Bolam E
- Boland E
- Bormans D
- Borthwick N
- Bowring F
- Boyd A
- Bradley P
- Brenner T
- Bridges-Webb A
- Briner C
- Brown C
- Brown P
- Brown-O'Sullivan C
- Bruce S
- Brunt E
- Budd W
- Bulbulia YA
- Bull M
- Burbage J
- Burn A
- Buttigieg KR
- Byard N
- Cabrera Puig I
- Calvert A
- Camara S
- Cao M
- Cappuccini F
- Cardona R
- Cardoso JR
- Carr M
- Carroll MW
- Carson-Stevens A
- Carvalho YDM
- Casey HR
- Cashen P
- Castro LC
- Castro TRY
- Cathie K
- Cavey A
- Cerbino-Neto J
- Cezar LFF
- Chadwick J
- Chanice C
- Chapman D
- Charlton S
- Cheliotis KS
- Chelysheva I
- Chester O
- Chiplin E
- Chita S
- Cho J-S
- Cicconi P
- Cifuentes L
- Clark E
- Clark M
- Clutterbuck EA
- Colin-Jones R
- Collins AM
- Collins SLK
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- Conlon CP
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- Cooper C
- Cooper R
- Cornelissen L
- Corrah T
- Cosgrove CA
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- Costa FB
- Cox T
- Crocker WEM
- Crosbie S
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- da Costa DM
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- Davies J
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- de Carvalho JAM
- De Jager J
- de Jesus Jnr S
- De Oliveira Kalid LM
- Dearlove D
- Demissie T
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- Di Marco S
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- Dos Santos TG
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- Themistocleous Y
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- Thomas TM
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- Tiongson GF
- Tladinyane B
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- Tomic A
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- Vekemans J
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- Verheul MK
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- Watson MEE
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- Wellbelove Z
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- Willingham S
- Winslow R
- Woods D
- Woodyer M
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- Wright D
- Wroblewska M
- Yao A
- Yim YTN
- Zambrano MB
- Zimmer RL
- Zizi D
- Zuidewind P
- Publication venue
- Elsevier
- Publication date
- 01/02/2021
- Field of study
BACKGROUND: The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered. METHODS: We present data from three single-blind randomised controlled trials-one phase 1/2 study in the UK (COV001), one phase 2/3 study in the UK (COV002), and a phase 3 study in Brazil (COV003)-and one double-blind phase 1/2 study in South Africa (COV005). As previously described, individuals 18 years and older were randomly assigned 1:1 to receive two standard doses of ChAdOx1 nCoV-19 (5 × 1010 viral particles) or a control vaccine or saline placebo. In the UK trial, a subset of participants received a lower dose (2·2 × 1010 viral particles) of the ChAdOx1 nCoV-19 for the first dose. The primary outcome was virologically confirmed symptomatic COVID-19 disease, defined as a nucleic acid amplification test (NAAT)-positive swab combined with at least one qualifying symptom (fever ≥37·8°C, cough, shortness of breath, or anosmia or ageusia) more than 14 days after the second dose. Secondary efficacy analyses included cases occuring at least 22 days after the first dose. Antibody responses measured by immunoassay and by pseudovirus neutralisation were exploratory outcomes. All cases of COVID-19 with a NAAT-positive swab were adjudicated for inclusion in the analysis by a masked independent endpoint review committee. The primary analysis included all participants who were SARS-CoV-2 N protein seronegative at baseline, had had at least 14 days of follow-up after the second dose, and had no evidence of previous SARS-CoV-2 infection from NAAT swabs. Safety was assessed in all participants who received at least one dose. The four trials are registered at ISRCTN89951424 (COV003) and ClinicalTrials.gov, NCT04324606 (COV001), NCT04400838 (COV002), and NCT04444674 (COV005). FINDINGS: Between April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4-74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3-85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59-0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3-91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0-69·9] at <6 weeks). These observations are supported by immunogenicity data that showed binding antibody responses more than two-fold higher after an interval of 12 or more weeks compared with an interval of less than 6 weeks in those who were aged 18-55 years (GMR 2·32 [2·01-2·68]). INTERPRETATION: The results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim analysis of the trials and confirm that the vaccine is efficacious, with results varying by dose interval in exploratory analyses. A 3-month dose interval might have advantages over a programme with a short dose interval for roll-out of a pandemic vaccine to protect the largest number of individuals in the population as early as possible when supplies are scarce, while also improving protection after receiving a second dose. FUNDING: UK Research and Innovation, National Institutes of Health Research (NIHR), The Coalition for Epidemic Preparedness Innovations, the Bill & Melinda Gates Foundation, the Lemann Foundation, Rede D'Or, the Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016.
- Author
- Aach M
- Abbasi G
- Abdallah B
- Abdallah TB
- Abdelghani KB
- Abdelghni KB
- Abdelhamid YA
- Abdelhamid YA
- Abdelmonem SA
- Abe T
- Abellan-Lencina R
- Abellan-Lencina R
- Abellán AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abentroth LR
- Abougabal AM
- Abu-Habsa M
- Abu-Habsa M
- Achurra P
- Adedugbe I
- Adeniji K
- Adwaney A
- Adwaney A
- Aguilar-Alonso E
- Aguilera E
- Aguirre H
- Aguirre-Sánchez J
- Ahmad A
- Ahmad A
- Akcan A
- Aktepe O
- Al Azab A
- Al Sibai JZ
- Al-Ansary AM
- Al-Fares A
- Al-Saati T
- Ala-Kokko T
- Alabert M
- Alamoudi W
- Albaiceta GM
- Albaiceta GM
- Albaiceta GM
- Albaladejo-Otón MD
- Alban L
- Albrecht M
- Alegría L
- Alegría L
- Alejandro O
- Alfaro MA
- Algendi MA
- Ali AA
- Ali MA
- Aliev I
- Alkhan J
- Allaouchiche B
- Allegue JM
- Allut JL
- Allut JL
- Almaziad S
- Almeida R
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Almudévar PM
- Alonso A
- Alonso DC
- Altaba S
- Altook R
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- Alzahaby KM
- Amarante G
- Amaro R
- Amato MB
- Amin R
- Amour J
- Ampatzidou F
- Ampatzidou F
- Ampatzidou F
- Anandanadesan R
- Andersen GØ
- Andreis DT
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- Anguel N
- Antoniades CA
- Antonini MV
- Antonucci E
- Antonucci E
- Anwar S
- Anzola Y
- Apolo DX
- Aragão I
- Aragão I
- Araponga GP
- Araponga GP
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- Arizmendi AM
- Arminda B
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- Beshey BN
- Beurton A
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- Bhatti P
- Bianchin MM
- Bihari S
- Bihari S
- Bilotta F
- Bioethics work group of SEMICYUC
- Biradar V
- Biradar V
- Birchmeier C
- Bird GT
- Birri PN
- Birri PN
- Black E
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- Blackwood B
- Blanch L
- Blanco GA
- Blanco GA
- Blankman P
- Blunden M
- Blunden M
- Bobi Q
- Boerma EC
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- Bonten MJ
- Bonvicini D
- Boots R
- Borges JB
- Bos LJ
- Bosch F
- Bosch FH
- Boscolo A
- Boscolo A
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- Camarena-Alejo G
- Camblor PM
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- Campello E
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- Cangueiro TC
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- Capilla F
- Capuzzo M
- Carbon N
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- Carbonara M
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- Carmona SA
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- Carpio D
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- Casey WF
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- Castañeda DP
- Castegren M
- Castellanos A
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- Cavicchi FZ
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- Cea L
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- Ceniccola GD
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- Cerejo A
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- Chalari E
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- Chang Y
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- Chapman M
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- Chaves S
- Checcacci SC
- Chen CM
- Chen HC
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- Chimenti L
- Chiurazzi C
- Cho YJ
- Chocron S
- Cholley B
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- Chou W
- Chouchene I
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- Chung EJ
- Chung WY
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- Colombo A
- Colombo R
- Comans T
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- Connolly B
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- Conway D
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- Coquerel D
- Cordeiro CP
- Corkill R
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- Correa-Morales A
- Corte FD
- Cortés DO
- Cortés SD
- Costa CR
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- Costa RG
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- Critical Care Research Group
- Cruciger O
- Cruz C
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- Csernus V
- Cuellar AI
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- de Guadiana-Romualdo LG
- de Jong E
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- de la Torre-Prados MV
- de la Torre-Prados MV
- de Lange DW
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- Delamarre L
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- Demoule A
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- Department of Professional Development ESICM
- Desai KA
- DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators
- Devlin J
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- Dit Latte DD
- Divatia JV
- Dizon JS
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- Dunn-Siegrist I
- Dunne L
- Durlinger E
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- Duska F
- Dávila F
- Díaz A
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- Dünser M
- Dąbrowski M
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- EDISVAL Group
- EDISVAL Group
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- Elias-Jones I
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- Kostopoulos A
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- Kuan LY
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- Macias-Guarasa I
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- Martin-Loeches I
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- Martin-Loeches I
- Martinez PC
- Martinez-Lopez P
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- Martín MC
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- Min SH
- Mirabella L
- Mirek S
- Misran H
- Mittal S
- Mittelbrum CP
- Mittelbrum CP
- Miyajima I
- Miyamoto K
- Mizobuchi S
- Miñambres E
- Mogensen KM
- Mokart D
- Mokri A
- Molina JA
- Molinos E
- Molnár Z
- Momma AK
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- Mongkolpun W
- Moniz I
- Monnet X
- Monroy NS
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- Monteiro E
- Montenegro AP
- Montero JG
- Montero RM
- Montoya AA
- Moodie S
- Moodie S
- Moore J
- Moore J
- Moors I
- Moraes MM
- Moraes RB
- Morales MA
- Moreau AS
- Moreno AP
- Moreno G
- Moreno S
- Moreno-Gonzalez G
- Moreno-Gonzalez G
- Morente-Constantin E
- Morgan E
- Morgan P
- Morgan P
- Morgan R
- Mori LB
- Morimoto T
- Morán I
- Mota A
- Motos A
- Motta MF
- Motta MF
- Moursia C
- Mouyis K
- Movsisyan V
- Mrozek S
- Mudersbach E
- Mukhopadhyay A
- Mukhtar S
- Mulder P
- Munshi R
- Murbach LD
- Murbach LD
- Murcia J
- Musiał J
- Musiał J
- Mutlu F
- Muñoz JJ
- Myatra SN
- Myers RB
- Mårtensson J
- Mårtensson J
- Möller C
- Müller MC
- N JK
- N JK
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- Nagashima F
- Nagy H
- Nakamae MN
- Nakamae MN
- Nakity R
- Nakos G
- Namgung H
- Nanas S
- Naser B
- Nashan B
- Nastou M
- Navis GJ
- Negro A
- Neitzke NM
- Neto AS
- Neves AD
- Nevière R
- Ngu WC
- Nguyen DN
- Nieto B
- Nieto OR
- Nijsten MW
- Nijsten MW
- Nikandish RN
- Nirmalan M
- Nobile L
- Nomikos T
- Norberg E
- Norkiene I
- Norrenberg M
- Nottin S
- Novotni D
- Nseir S
- Nseir S
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- Ntantana A
- Ntzouvani A
- Nuevo-Ortega P
- Numan T
- Nunes A
- Nunes A
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- Nurses of the Central and General ICUs of Shiraz Namazi Hospital
- Nußbaum B
- Nußbaum B
- Nußbaum B
- Nyberg A
- Nyman M
- Nyunga M
- Nóbrega JJ
- O'Dea KP
- Oddo M
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- Ogasawara SM
- Ogasawara SM
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- Ordoñez PF
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- Ori C
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- Ortin A
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- Ortolano F
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- Osaku EF
- Osaku EF
- Ospina-Tascón G
- Ospina-Tascón G
- Osse RJ
- Ossorio ME
- Osuna A
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- Otulakowski G
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- Palma I
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- Papaparaskeva K
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- Parienti JJ
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- Park KJ
- Park MS
- Park SY
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- Parovichnikova E
- Parpibaev F
- Parrilla F
- Parsikia A
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- Patel SJ
- Patet C
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- Paugam-Burtz C
- Payen D
- Payen JF
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- Pelegrini AM
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- Pellegrini M
- Pellegrini M
- Pellizzari A
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- Pequeno RS
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- Perchiazzi G
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- Perez-Sanchez J
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- Piotrowska K
- Piqueras CS
- Pires EM
- Pires EM
- Pires T
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- Pizarraya AG
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- Plata-Menchaca EP
- Plattner O
- Plotnikow G
- PLUG Working group
- Plummer M
- Plummer MP
- Plummer MP
- Poitou T
- Politi E
- Politi F
- Polok K
- Polok K
- Pomprapa A
- Pooresmaeel F
- POPC-CB investigators
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- Porta A
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- Poveda-Andrés JL
- Povoa P
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- Prabu NR
- Prada DA
- Prats RG
- Preiser JC
- Preiser JC
- Preiser JC
- Prescott H
- Proença L
- Protti A
- PRoVENT investigators and the PROVE Network
- Prowle JR
- Prowle JR
- Psarra K
- Puebla C
- Puerta RR
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- Puig F
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- Puyraveau M
- Pène F
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- Pérez MA
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- Pérez-Fernández XL
- Pérez-Madrigal A
- Póvoa P
- Póvoa P
- Qiu C
- Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group
- Quesada-Garcia G
- Quint M
- Quintana MM
- Quintard H
- Raadts A
- Rabbat A
- Rabello L
- Radermacher P
- Radermacher P
- Radermacher P
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- Rafik MM
- Ragazzi R
- Raja M
- Rajput RK
- Ramalingam S
- Ramazanoglu A
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- Ramírez CS
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- Ranzani OT
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- Rawn JD
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- Renal Transplantation HUVR
- Renault A
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- Renuka MK
- Research O
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- Ribas MP
- Ribeiro JM
- Ribeiro MO
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- Rietdijk W
- Rieusset J
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- Rigobello A
- Rigol M
- Rigol M
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- Rimmer E
- Ringaitiene D
- Risolo S
- Risso-Vazquez A
- Rittayamai N
- Riva M
- Rivera JJ
- Rivera-Ginés B
- Roberts S
- Robertsen A
- Robertson CS
- Robertson E
- Robinson MK
- Robles CM
- Robles CM
- Robles JC
- Rocha AP
- Rocha LL
- Rochwerg B
- Rodrigues CM
- Rodrigues FF
- Rodrigues M
- Rodriguez A
- Rodriguez A
- Rodriguez N
- Rodriguez-Ruiz E
- Rodriguez-Ruiz E
- Rodríguez A
- Rodríguez MD
- Rodríguez-Mejías C
- Roedl K
- Roedl K
- Roedl K
- Roedl K
- Roedl K
- Roeker LE
- Roig AL
- Rolland-Debord C
- Romdhani S
- Romera-Peregrina I
- Romera-Peregrina I
- Romero OM
- Romero OM
- Roneus A
- Rood P
- Rood PJ
- Rooyackers O
- Roquilly A
- Ros J
- Rose L
- Rosello DB
- Rosenqvist M
- Rosselló AF
- Rossetti M
- Rossi I
- Rosstalnaya A
- Rotzel HB
- Routsi C
- Rouze A
- Rowland MJ
- Roy A
- Rozec B
- Rubenfeld GD
- Rubio JJ
- Rubulotta F
- Rubulotta F
- Rubulotta F
- Rueda-Molina C
- Ruiz BL
- Ruiz F
- Ruiz-Ramos J
- Rulisek J
- Rusin CG
- Rusinova K
- Russ M
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- Rutter K
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- Rygård SL
- Ryu HG
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- Sabater-Riera J
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- Sabetian G
- Sabetiyan G
- Sabirov D
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- Safi F
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- Sakaguchi M
- Sakamoto Y
- Salciccioli JD
- Saldaña T
- Sales FL
- Salido-Díaz L
- Salluh J
- Salluh J
- Salluh JI
- Saludes P
- Samain E
- Samy W
- Sanchez JG
- Sanchez M
- Sanchez S
- Sanders S
- Santafe M
- Santana MC
- Santana PS
- Santana SR
- Santiago-Ruiz F
- Santibañez M
- Santini A
- Santos AC
- Santos C
- Santos C
- Santos ER
- Sanz JG
- Saoli M
- Saraj N
- Sasso T
- Sattayasomboon Y
- Saugel B
- Savchenko V
- Savvidou S
- Sbraga F
- Sbraga F
- Scaramuzzo G
- Scaramuzzo G
- Scaravilli V
- Schellnegger R
- Schildhauer C
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- Schlemmer B
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- Schneeweiss B
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- Schultz M
- Schultz M
- Schultz MJ
- Schwarzkopf D
- Schwarzkopf D
- Schwedhelm E
- Schweizer R
- Schädler D
- Scola E
- Sedation an Delirium Group Hospital Universitari de Bellvitge
- Segaran E
- Segelsjö M
- Seguin P
- Sekhon M
- Seller-Perez G
- Seller-Pérez G
- SEMICYUC/GETGAG Working Group
- Sen E
- Senussi T
- Serrano JA
- Sertedaki A
- Servadei F
- Sessler DI
- Sganzerla E
- Shafi M
- Shafi M
- Shalhoub J
- Sharipova V
- Sharma S
- Sharma SC
- Sharman M
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- Shaw JE
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- Shevill DD
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- Shinotsuka CR
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- Shyu LJ
- Siddiqui S
- Siedler S
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- Simioni P
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- Singer M
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- Singh VK
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- Siniscalchi A
- Sipylaite J
- SIRAKI group
- Sirvent JM
- Sivakumar S
- Sivasamy V
- Six S
- Sjölin J
- Skaga NO
- Skarzynski M
- Sklar M
- Skorko A
- Skorup P
- Skouri W
- Skrypnikov V
- Slooter AJ
- Slooter AJ
- Sma N
- Smani Y
- Smit B
- Smit B
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- Smulders YM
- Snelson C
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- Soares M
- Sola EC
- Solari D
- Solari D
- Soliman IW
- Soliman M
- Sollitto F
- Sondag L
- Soon Y
- Soriano R
- Soto D
- Sotos F
- Sotos F
- Sottile JP
- Sousa M
- Souza RB
- Souza RB
- Souza RB
- SPACeR group (Surrey Peri-operative Anaesthesia and Critical Care Collaborative Research Group)
- Spadaro S
- Spadaro S
- Spadaro S
- Spanaki AM
- Spanaki AM
- Spapen HD
- Spasova T
- Spiezia L
- Spina S
- Spoelstra-de Man A
- Spronk PE
- Spuler S
- Srinivasan S
- Srinivasan S
- Sriram S
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- Steenstra RJ
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- Svoren-Jabalera E
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- Talwar N
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- Tamura T
- Taneja S
- Tang Z
- Taniguchi LU
- Taniguchi LU
- Tapia P
- Tarancón CM
- Tarazi T
- Tavares AL
- TAVeM study group
- TAVeM study Group
- Tavladaki T
- Tavladaki T
- Teboul JL
- Teixeira C
- Teixeira C
- Tejeda-Huezo BC
- Tejero AP
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- Ten Kleij M
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- Terranova S
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- Tharmalingam B
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- Thibault-Halman G
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- Thomas-Rüddel DO
- Thomsen LP
- Thooft A
- Tijero J
- Timenetsky KT
- Tirlapur N
- Tizón AI
- Tjepkema-Cloostermans MC
- Toapanta ND
- Togal T
- Tokuda Y
- Tollisen KH
- Tomar DS
- Tomar DS
- Tomlinson G
- Tomás R
- Tonietto TA
- Topeli A
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- Torrella PE
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- Torres A
- Torres A
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- Travierso C
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- Troitskaya V
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- Tsang JL
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- Tsolakoglou I
- Tsvetanova-Spasova T
- Tuinman PR
- Turgeon AF
- Turki S
- Turki S
- Turkoglu LM
- Tyagi N
- Uddin I
- Urrea C
- Uya J
- Uygur ML
- Uz Z
- Vaara ST
- Vakalos A
- Valbuena BL
- Valbuena BL
- Valentino F
- Vales C
- Valhonrat IL
- Vallejo-Pascual ME
- van Baal L
- Van Dam MJ
- van de Schoor F
- van Delden JJ
- van den Berg JP
- van den Boogaard M
- van den Boogaard M
- van den Broek JM
- van der Horst IC
- van der Horst IC
- van der Jagt M
- van der Poll T
- van Dijk D
- van Ewijk CE
- van Galen T
- Van Gorp V
- van IJzendoorn MC
- van Klei WA
- van Meurs M
- van Oers JA
- van Putten MJ
- van Straaten HM
- van Tertholen K
- van Wijk A
- Vaquerizo C
- Vaquero RH
- Vaquero RH
- Varas JL
- Vardas K
- Varela A
- Vargas A
- Varghese S
- Vargiolu A
- Varis E
- Vaz-Ferreira A
- Vazin A
- Vazquez AR
- Vazquez D
- Veganzones J
- Veiga LN
- Veiga LN
- Velayos C
- Vera A
- Vera M
- Verdejo JA
- Vereecke HE
- Veronesi M
- Vestito MC
- Viana LV
- Viana MV
- Vicente R
- Viciana R
- Vicka V
- Vickers L
- Vieira J
- Vieira JC
- Vieira JC
- Vieira JC
- Vieira JM
- Vieira JM
- Vieira SR
- Vieira SR
- Viera MA
- Vilas-Boas A
- Villa G
- Villacres S
- Villajero P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villamizar PR
- Villarejo P
- Villarreal E
- Villazala R
- Villazala R
- Villén LM
- Vincent F
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Viola L
- Vlachou A
- Vlasakov V
- Volta CA
- Volta CA
- Vorona S
- Vázquez CF
- Wade C
- Wagenpfeil G
- Wagenpfeil S
- Waldauf P
- Waldauf P
- Waldum-Grevbo BE
- Walling S
- Walter E
- Walter E
- Walter M
- Walther G
- Wang CH
- Wangensteen R
- Watson G
- Waydhas C
- Weaver A
- Weber-Carstens S
- Weber-Carstens S
- Weijs PJ
- Weiler N
- Weiler N
- Welsh SP
- West A
- Westbrook J
- Wetterslev J
- Wignall I
- Wilkerson P
- Wilkinson J
- Wilkman E
- Williams L
- Willis K
- Wilske F
- Winding RW
- Windpassinger M
- Winkler MS
- Winterwerp D
- Witter T
- Wollersheim T
- Wollersheim T
- Wong CM
- Woodward CL
- Worral R
- Worrall R
- Wozniak S
- Wright C
- Wright S
- Wruck ML
- Wu SH
- Wykes K
- Wykes K
- Włudarczyk A
- Xiol EA
- Yamada KC
- Yamamoto T
- Yamamura H
- Yamashita K
- Yan WW
- Yasuda H
- Yatabe T
- Yatabe T
- Yehia A
- Yelken BB
- Yeter H
- Yıldırım AE
- Yokoyama M
- Yoo SH
- Yoshida T
- Youn A
- Young R
- Yousef K
- Yu CH
- Yugi G
- Yuste AS
- Yuste AS
- Zacharov S
- Zakharkina T
- Zakynthinos E
- Zaleska-Kociecka M
- Zamel R
- Zamora DF
- Zand A
- Zand F
- Zand F
- Zand F
- Zangrillo A
- Zaponi RS
- Zarychanski R
- Zechner F
- Zeman PM
- Zepeda EM
- Zerpa MC
- Zhang LA
- Zhen CE
- Zijlstra JG
- Zitta K
- Zolfaghari P
- Zuleika A
- Zöllner C
- Álvarez TP
- Álvarez-Lerma F
- Ávila-Espinoza RE
- Ñamendys-Silva SA
- Özçelik M
- Ünal N
- Şencan I
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
A Comprehensive Review on Ocimum basilicum
- Author
- Aarthi N Murugan K
- Aishwath OP Nibauria SV
- Alshishani AA Saad B, Semail NF, Salhimi SM, Mohd Talib MK
- Alves-Silvaa JM Dias dos Santosa SM, Pintadob ME, Perez-Alvarezc JA, Fernandez-Lopezc J, Viuda-Martosc M
- Alvi MN Ahmad S, Rehman K
- Amrani S Harnafi H, Gadi D, Mechfi H, Legssyer A, Ariz M, Martin-Nizard F, Bosca L
- Andrade TCB Lima SG, Freitas RM, Rocha MS, Islam T, Silva TG, et al
- Araldi RP Assaf SMR, Carvalho RF, Caldas MA, Carvalho R, Souza JM, Magnelli RF, Modolo GD, Roperto FP, Stocco1 C and Becak W
- Bais HP Walker TS, Schweizer HP, Vivanco JM
- Bantis F Ouzounis T, Radoglou K.
- Basilico MZ Basilico JC
- Benitez PN Leon MEM, Stashenko EE
- Bora KS Arora S, Shri R.
- Bravo E Amrani S, ArizM, Harnafi H, Napolitano M.
- Cascaes MM Skelding Pinheiro Guilhon GM, Aguiar rade EH, Bichara Zoghbi MG, Silva Santos L
- Chang SS Ostric-Matijasevic B, Hsieh OAL, Huang CL.
- Davies J
- Del-Vechio-Vieira G Vieira de Sousa O, Miranda MA, Senna-Valle L, Coelho Kaplan MA
- Ding J Huang C, Peng Z, Xie Y, Deng S, Nie YZ, Xu TL, Ge WH, Li WG, Li F.
- Eccles R Griffiths DH, Newton CG, Tolley NS
- Faleiro JR El-Saad MA, Al-Abbad AH
- Fan S Chang J, Zong Y, Hu G, Jia J
- Flanigan PM Niemeyer ED
- Freire MM Marques OM, Costa M
- Gakuubi MM
- Galeotti N Ghelardini C, Cesare Mannelli LD, Mazzanti G, Baghiroli L, Bartolini A
- Galhiane MS Rissato SR, Chierice GO, Almeida MV, Silva LC
- Gamliel A Yarden O
- Gosavi VD Sharma S
- Govindarajan M Sivakumar R, Rajeswary M, Yogalakshmi K
- Green CP Osborne P
- Gulcin I Elmastas M, Aboul-Enein HY.
- Gupta A Karjikar M, Nair J.
- Han GH Kim SK, Kyung Seok Yoon P, Kang Y, Kim BS, Fu Y
- Harnafia H Azizb M, Amrania S.
- Hassanpouraghdam MB Hassani A, Vojodi L, Farsadakhtar N
- Hossain MA Kabir MJ, Salehuddin SM, Das AK, Singha SK, Alam MK, Rahman A
- Hui-Ping W Mu Z, Yong L, Weng-Quan L
- Hussain AI Anwar F, Sherazi STH, Przybylski R
- Jadhav NM Thergaonkar RS, Deodhar MA
- Javanmardi J Stushnoff C, Locke E, Vivanco JM.
- Kamatou GPP Viljoen AM
- Kathirvel P Ravi S
- Khalil A
- Khalil AA Rahman U, Khan MR, Sahar A, Mehmoodac T, Muneeb Khana
- Khazaeia N Esmaiilia M, Djomehb ZE, Ghasemlouc M, Joukid M.
- Kim HJ Chen F, Wang X, Rajapakse NC
- Kim YK Lee HS, Min SS, Seol GH
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