946 research outputs found

    Matroid and Knapsack Center Problems

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    In the classic kk-center problem, we are given a metric graph, and the objective is to open kk nodes as centers such that the maximum distance from any vertex to its closest center is minimized. In this paper, we consider two important generalizations of kk-center, the matroid center problem and the knapsack center problem. Both problems are motivated by recent content distribution network applications. Our contributions can be summarized as follows: 1. We consider the matroid center problem in which the centers are required to form an independent set of a given matroid. We show this problem is NP-hard even on a line. We present a 3-approximation algorithm for the problem on general metrics. We also consider the outlier version of the problem where a given number of vertices can be excluded as the outliers from the solution. We present a 7-approximation for the outlier version. 2. We consider the (multi-)knapsack center problem in which the centers are required to satisfy one (or more) knapsack constraint(s). It is known that the knapsack center problem with a single knapsack constraint admits a 3-approximation. However, when there are at least two knapsack constraints, we show this problem is not approximable at all. To complement the hardness result, we present a polynomial time algorithm that gives a 3-approximate solution such that one knapsack constraint is satisfied and the others may be violated by at most a factor of 1+ϵ1+\epsilon. We also obtain a 3-approximation for the outlier version that may violate the knapsack constraint by 1+ϵ1+\epsilon.Comment: A preliminary version of this paper is accepted to IPCO 201

    Assessing direct contributions of morphological awareness and prosodic sensitivity to children’s word reading and reading comprehension

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    We examined the independent contributions of prosodic sensitivity and morphological awareness to word reading, text reading accuracy, and reading comprehension. We did so in a longitudinal study of English-speaking children (N = 70). At 5 to 7 years of age, children completed the metalinguistic measures along with control measures of phonological awareness and vocabulary. Children completed the reading measures two years later. Morphological awareness, but not prosodic sensitivity made a significant independent contribution to word reading, text reading accuracy and reading comprehension. The effects of morphological awareness on reading comprehension remained after controls for word reading. These results suggest that morphological awareness needs to be considered seriously in models of reading development and that prosodic sensitivity might have primarily indirect relations to reading outcomes. Keywords: Morphological Awareness; Prosody; Word Reading; Reading Comprehension

    Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

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    The translocation of synaptic Zn2+ to the cytosolic compartment has been studied to understand Zn2+ neurotoxicity in neurological diseases. However, it is unknown whether the moderate increase in Zn2+ in the cytosolic compartment affects memory processing in the hippocampus. In the present study, the moderate increase in cytosolic Zn2+ in the hippocampus was induced with clioquinol (CQ), a zinc ionophore. Zn2+ delivery by Zn-CQ transiently attenuated CA1 long-term potentiation (LTP) in hippocampal slices prepared 2 h after i.p. injection of Zn-CQ into rats, when intracellular Zn2+ levels was transiently increased in the CA1 pyramidal cell layer, followed by object recognition memory deficit. Object recognition memory was transiently impaired 30 min after injection of ZnCl2 into the CA1, but not after injection into the dentate gyrus that did not significantly increase intracellular Zn2+ in the granule cell layer of the dentate gyrus. Object recognition memory deficit may be linked to the preferential increase in Zn2+ and/or the preferential vulnerability to Zn2+ in CA1 pyramidal neurons. In the case of the cytosolic increase in endogenous Zn2+ in the CA1 induced by 100 mM KCl, furthermore, object recognition memory was also transiently impaired, while ameliorated by co-injection of CaEDTA to block the increase in cytosolic Zn2+. The present study indicates that the transient increase in cytosolic Zn2+ in CA1 pyramidal neurons reversibly impairs object recognition memory

    MRI Findings in Patients with a History of Failed Prior Microvascular Decompression for Hemifacial Spasm: How to Image and Where to Look

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    ABSTRACT BACKGROUND AND PURPOSE: A minority of patients who undergo microvascular decompression for hemifacial spasm do not improve after the first operation. We sought to determine the most common locations of unaddressed neurovascular contact in patients with persistent or recurrent hemifacial spasm despite prior microvascular decompression

    Mode-coupling theory for multiple-time correlation functions of tagged particle densities and dynamical filters designed for glassy systems

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    The theoretical framework for higher-order correlation functions involving multiple times and multiple points in a classical, many-body system developed by Van Zon and Schofield [Phys. Rev. E 65, 011106 (2002)] is extended here to include tagged particle densities. Such densities have found an intriguing application as proposed measures of dynamical heterogeneities in structural glasses. The theoretical formalism is based upon projection operator techniques which are used to isolate the slow time evolution of dynamical variables by expanding the slowly-evolving component of arbitrary variables in an infinite basis composed of the products of slow variables of the system. The resulting formally exact mode-coupling expressions for multiple-point and multiple-time correlation functions are made tractable by applying the so-called N-ordering method. This theory is used to derive for moderate densities the leading mode coupling expressions for indicators of relaxation type and domain relaxation, which use dynamical filters that lead to multiple-time correlations of a tagged particle density. The mode coupling expressions for higher order correlation functions are also succesfully tested against simulations of a hard sphere fluid at relatively low density.Comment: 15 pages, 2 figure

    On the Treewidth of Dynamic Graphs

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    Dynamic graph theory is a novel, growing area that deals with graphs that change over time and is of great utility in modelling modern wireless, mobile and dynamic environments. As a graph evolves, possibly arbitrarily, it is challenging to identify the graph properties that can be preserved over time and understand their respective computability. In this paper we are concerned with the treewidth of dynamic graphs. We focus on metatheorems, which allow the generation of a series of results based on general properties of classes of structures. In graph theory two major metatheorems on treewidth provide complexity classifications by employing structural graph measures and finite model theory. Courcelle's Theorem gives a general tractability result for problems expressible in monadic second order logic on graphs of bounded treewidth, and Frick & Grohe demonstrate a similar result for first order logic and graphs of bounded local treewidth. We extend these theorems by showing that dynamic graphs of bounded (local) treewidth where the length of time over which the graph evolves and is observed is finite and bounded can be modelled in such a way that the (local) treewidth of the underlying graph is maintained. We show the application of these results to problems in dynamic graph theory and dynamic extensions to static problems. In addition we demonstrate that certain widely used dynamic graph classes naturally have bounded local treewidth

    Affective Man-Machine Interface: Unveiling human emotions through biosignals

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    As is known for centuries, humans exhibit an electrical profile. This profile is altered through various psychological and physiological processes, which can be measured through biosignals; e.g., electromyography (EMG) and electrodermal activity (EDA). These biosignals can reveal our emotions and, as such, can serve as an advanced man-machine interface (MMI) for empathic consumer products. However, such a MMI requires the correct classification of biosignals to emotion classes. This chapter starts with an introduction on biosignals for emotion detection. Next, a state-of-the-art review is presented on automatic emotion classification. Moreover, guidelines are presented for affective MMI. Subsequently, a research is presented that explores the use of EDA and three facial EMG signals to determine neutral, positive, negative, and mixed emotions, using recordings of 21 people. A range of techniques is tested, which resulted in a generic framework for automated emotion classification with up to 61.31% correct classification of the four emotion classes, without the need of personal profiles. Among various other directives for future research, the results emphasize the need for parallel processing of multiple biosignals

    Co-ordination of local policies for urban development and public transportation in four Swiss cities

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    The present article aims at assessing the possibility for urban areas to coordinate local policies of urban development and public transportation and at explaining the differences in this achievement between urban regions. In order to do so, the study draws support from two empirical sources: a historical analysis of the "mass-production" generated by the public service sectors in the field of transport and urban development in the cities of Basel, Bern, Geneva, and Lausanne since 1950, and a series of six case studies in these four cities. The study identifies factors located both at context level regarding morphological and geographical conditions as well as institutional settings and case-specific idiosyncrasies regarding organizational structure, past policy decisions, as well as vocational cultures that determine the possibility for urban areas to meet the need for policy coordination
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