1,439 research outputs found
Dielectrics for long term space exposure and spacecraft charging: A briefing
Charging of dielectrics is a bulk, not a surface property. Radiation driven charge stops within the bulk and is not quickly conducted to the surface. Very large electric fields develop in the bulk due to this stopped charge. At space radiation levels, it typically requires hours or days for the internal electric fields to reach steady state. The resulting electric fields are large enough to produce electrical failure within the insulator. This type failure is thought to produce nearly all electric discharge anomalies. Radiation also induces bond breakage, creates reactive radicals, displaces atoms and, in general, severely changes the chemistry of the solid state material. Electric fields can alter this process by reacting with charged species, driving them through the solid. Irradiated polymers often lose as much as a percent of their mass, or more, at exposures typical in space. Very different aging or contaminant emission can be induced by the stopped charge electric fields. These radiation effects are detailed
Results of literature search on dielectric properties and electron interaction phenomena related to spacecraft charging
The objective of the literature search was to determine the required material properties and electron interaction parameters needed for modeling charge buildup and breakdown in insulators. A brief overview of the results of the literature search is given. A partial list of the references covered is included in a bibliography. Although inorganic insulators were also considered in the search, coverage is limited to the organics, primarily Kapton and Teflon
Radiation-induced insulator discharge pulses in the CRRES internal discharge monitor satellite experiment
The Internal Discharge Monitor (IDM) was designed to observe electrical pulses from common electrical insulators in space service. The sixteen insulator samples included twelve planar printed circuit boards and four cables. The samples were fully enclosed, mutually isolated, and space radiation penetrated 0.02 cm of aluminum before striking the samples. Pulsing began on the seventh orbit, the maximum pulse rate occurred on the seventeenth orbit when 13 pulses occurred, and the pulses slowly diminished to about one per 3 orbits six months later. After 8 months, the radiation belts abruptly increased and the pulse rates attained a new high. These pulse rates were in agreement with laboratory experience on shorter time scales. Several of the samples never pulsed. If the pulses were not confined within IDM, the physical processes could spread to become a full spacecraft anomaly. The IDM results indicate the rate at which small insulator pulses occur. Small pulses are the seeds of larger satellite electrical anomalies. The pulse rates are compared with space radiation intensities, L shell location, and spectral distributions from the radiation spectrometers on the Combined Release and Radiation Effects Satellite
Charge Storage Measuremens of Resistivity for Dielectric Samples from the CRRES Internal Discharge Monitor
Experimentally Derived Resistivity for Dielectric Samples From the CRRES Internal Discharge Monitor
Resistivity values were experimentally determined using charge storage methods for six samples remaining from the construction of the Internal Discharge Monitor (IDM) flown on the Combined Release and Radiation Effects Satellite (CRRES). Three tests were performed over a period of four to five weeks each in a vacuum of ~5×10-6 torr with an average temperature of ~25 ºC to simulate a space environment. Samples tested included FR4, PTFE, and alumina with copper electrodes attached to one or more of the sample surfaces. FR4 circuit board material was found to have a dark current resistivity of ~1×1018 Ω-cm and a moderately high polarization current. Fiber filled PTFE exhibited little polarization current and a dark current resistivity of ~3×1020 Ω-cm. Alumina had a measured dark current resistivity of ~3·1017 Ω-cm, with a very large and more rapid polarization. Experimentally determined resistivity values were two to three orders of magnitude more than found using standard ASTM test methods. The one minute wait time suggested for the standard ASTM tests is much shorter than the measured polarization current decay times for each sample indicating that the primary currents used to determine ASTM resistivity are caused by the polarization of molecules in the applied electric field rather than charge transport through the bulk of the dielectric. Testing over much longer periods of time in vacuum is required to allow this polarization current to decay away and to allow the observation of charged particles transport through a dielectric material. Application of a simple physics-based model allows separation of the polarization current and dark current components from long duration measurements of resistivity over day- to month-long time scales. Model parameters are directly related to the magnitude of charge transfer and storage and the rate of charge transport
B-Amyloid of Alzheimer\u27s Disease Induces Reactive Gliosis that Inhibits Axonal Outgrowth
Pathological lesions in the brains of patients with Alzheimer\u27s disease (AD) are characterized by dense deposits of the protein ,B-amyloid. The link between the deposition of B-amyloid in senile plaques and AD-associated pathology is, at present, controversial since there have been conflicting reports on whether the 39- 43 amino acid B-amyloid sequence is toxic or trophic to neurons. In this report, we show that B-amyloid peptide when presented as an insoluble substrate which mimics its conformation in vivo can induce cortical glial cells in vitro and in vivo to locally deposit chondroitin sulfate containingproteoglycan. In vitro the proteoglycan-containing matrix deposited by glia on B-amyloid blocks the usual ability of the peptide to allow cortical neurons to adhere and grow. Chondroitin sulfate-containing proteoglycan was also found in senile plaques of human AD tissue. We suggest that an additional effect of B-amyloid in the brain, which compounds the direct effects of ,8- amyloid on neurons, is mediated by the stimulation of astroglia to become reactive. Once in the reactive state, glial cells deposit large amounts of growth-inhibitory molecules within the neuropil which could impair neuronal process survival and regeneration leading to neurite retraction and/or dystrophy around senile plaques in AD
Matroid and Knapsack Center Problems
In the classic -center problem, we are given a metric graph, and the
objective is to open nodes as centers such that the maximum distance from
any vertex to its closest center is minimized. In this paper, we consider two
important generalizations of -center, the matroid center problem and the
knapsack center problem. Both problems are motivated by recent content
distribution network applications. Our contributions can be summarized as
follows:
1. We consider the matroid center problem in which the centers are required
to form an independent set of a given matroid. We show this problem is NP-hard
even on a line. We present a 3-approximation algorithm for the problem on
general metrics. We also consider the outlier version of the problem where a
given number of vertices can be excluded as the outliers from the solution. We
present a 7-approximation for the outlier version.
2. We consider the (multi-)knapsack center problem in which the centers are
required to satisfy one (or more) knapsack constraint(s). It is known that the
knapsack center problem with a single knapsack constraint admits a
3-approximation. However, when there are at least two knapsack constraints, we
show this problem is not approximable at all. To complement the hardness
result, we present a polynomial time algorithm that gives a 3-approximate
solution such that one knapsack constraint is satisfied and the others may be
violated by at most a factor of . We also obtain a 3-approximation
for the outlier version that may violate the knapsack constraint by
.Comment: A preliminary version of this paper is accepted to IPCO 201
Selection from read-only memory with limited workspace
Given an unordered array of elements drawn from a totally ordered set and
an integer in the range from to , in the classic selection problem
the task is to find the -th smallest element in the array. We study the
complexity of this problem in the space-restricted random-access model: The
input array is stored on read-only memory, and the algorithm has access to a
limited amount of workspace. We prove that the linear-time prune-and-search
algorithm---presented in most textbooks on algorithms---can be modified to use
bits instead of words of extra space. Prior to our
work, the best known algorithm by Frederickson could perform the task with
bits of extra space in time. Our result separates
the space-restricted random-access model and the multi-pass streaming model,
since we can surpass the lower bound known for the latter
model. We also generalize our algorithm for the case when the size of the
workspace is bits, where . The running time
of our generalized algorithm is ,
slightly improving over the
bound of Frederickson's algorithm. To obtain the improvements mentioned above,
we developed a new data structure, called the wavelet stack, that we use for
repeated pruning. We expect the wavelet stack to be a useful tool in other
applications as well.Comment: 16 pages, 1 figure, Preliminary version appeared in COCOON-201
Successful use of axonal transport for drug delivery by synthetic molecular vehicles
We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules. The complex efficiently enters nerve terminals after intramuscular or intradermal administration and travels within axonal processes to neuron cell bodies. The tripartite agent provided 100-fold amplification of saturable neural uptake events, delivering multiple drug molecules per complex. _In vivo_, analgesic drug delivery to systemic and to non-targeted neural tissues was greatly reduced compared to existing routes of administration, thus exemplifying the possibility of specific nerve root targeting and effectively increasing the potency of the candidate drug gabapentin 300-fold relative to oral administration
Mode-coupling theory for multiple-time correlation functions of tagged particle densities and dynamical filters designed for glassy systems
The theoretical framework for higher-order correlation functions involving
multiple times and multiple points in a classical, many-body system developed
by Van Zon and Schofield [Phys. Rev. E 65, 011106 (2002)] is extended here to
include tagged particle densities. Such densities have found an intriguing
application as proposed measures of dynamical heterogeneities in structural
glasses. The theoretical formalism is based upon projection operator techniques
which are used to isolate the slow time evolution of dynamical variables by
expanding the slowly-evolving component of arbitrary variables in an infinite
basis composed of the products of slow variables of the system. The resulting
formally exact mode-coupling expressions for multiple-point and multiple-time
correlation functions are made tractable by applying the so-called N-ordering
method. This theory is used to derive for moderate densities the leading mode
coupling expressions for indicators of relaxation type and domain relaxation,
which use dynamical filters that lead to multiple-time correlations of a tagged
particle density. The mode coupling expressions for higher order correlation
functions are also succesfully tested against simulations of a hard sphere
fluid at relatively low density.Comment: 15 pages, 2 figure
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