97 research outputs found
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Studying the Spatial Distribution of Physiological Effects on BOLD Signals Using Ultrafast fMRI
The blood-oxygen-level dependent (BOLD) signal in functional MRI (fMRI) reflects both neuronal activations and global physiological fluctuations. These physiological fluctuations can be attributed to physiological low frequency oscillations (pLFOs), respiration, and cardiac pulsation. With typical TR values, i.e., 2 s or longer, the high frequency physiological signals (i.e., from respiration and cardiac pulsation) are aliased into the low frequency band, making it hard to study the individual effect of these physiological processes on BOLD. Recently developed multiband EPI sequences, which offer full brain coverage with extremely short TR values (400 ms or less) allow these physiological signals to be spectrally separated. In this study, we applied multiband resting state scans on nine healthy participants with TR = 0.4 s. The spatial distribution of each physiological process on BOLD fMRI was explored using their spectral features and independent component analysis (ICA). We found that the spatial distributions of different physiological processes are distinct. First, cardiac pulsation affects mostly the base of the brain, where high density of arteries exists. Second, respiration affects prefrontal and occipital areas, suggesting the motion associated with breathing might contribute to the noise. Finally, and most importantly, we found that the effects of pLFOs dominated many prominent ICA components, which suggests that, contrary to the popular belief that aliased cardiac and respiration signals are the main physiological noise source in BOLD fMRI, pLFOs may be the most influential physiological signals. Understanding and measuring these pLFOs are important for denoising and accurately modeling BOLD signals
Second-Hand Stress: Neurobiological Evidence for a Human Alarm Pheromone
Alarm pheromones are airborne chemical signals, released by an individual into the environment, which transmit warning of danger to conspecifics via olfaction. Using fMRI, we provide the first neurobiological evidence for a human alarm pheromone. Individuals showed activation of the amygdala in response to sweat produced by others during emotional stress, with exercise sweat as a control; behavioral data suggest facilitated evaluation of ambiguous threat
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An Increase in Tobacco Craving Is Associated with Enhanced Medial Prefrontal Cortex Network Coupling
Craving is a key aspect of drug dependence that is thought to motivate continued drug use. Numerous brain regions have been associated with craving, suggesting that craving is mediated by a distributed brain network. Whether an increase in subjective craving is associated with enhanced interactions among brain regions was evaluated using resting state functional magnetic imaging (fMRI) in nicotine dependent participants. We focused on craving-related changes in the orbital and medial prefrontal cortex (OMPFC) network, which also included the subgenual anterior cingulate cortex (sgACC) extending into the ventral striatum. Brain regions in the OMPFC network are not only implicated in addiction and reward, but, due to their rich anatomic interconnections, may serve as the site of integration across craving-related brain regions. Subjective craving and resting state fMRI were evaluated twice with an ∼1 hour delay between the scans. Cigarette craving was significantly increased at the end, relative to the beginning of the scan session. Enhanced craving was associated with heightened coupling between the OMPFC network and other cortical, limbic, striatal, and visceromotor brain regions that are both anatomically interconnected with the OMPFC, and have been implicated in addiction and craving. This is the first demonstration confirming that an increase in craving is associated with enhanced brain region interactions, which may play a role in the experience of craving
A System to Monitor Cognitive Workload in Naturalistic High-Motion Environments
Across many careers, individuals face alternating periods of high and low attention and cognitive workload can impair cognitive function and undermine job performance. We have designed and are developing an unobtrusive system to Monitor, Extract, and Decode Indicators of Cognitive Workload (MEDIC) in naturalistic, high-motion environments. MEDIC is designed to warn individuals, teammates, or supervisors when steps should be taken to augment cognitive readiness. We first designed and manufactured a forehead sensor device that includes a custom fNIRS sensor and a three-axis accelerometer designed to be mounted on the inside of a baseball cap or headband, or standard issue gear such as a helmet or surgeon’s cap. Because the conditions under which MEDIC is designed to operate are more strenuous than typical research efforts assessing cognitive workload, motion artifacts in our data were a persistent issue. Results show wavelet-based filtering improved data quality to salvage data from even the highest-motion conditions. MARA spline motion correction did not further improve data quality. Our testing shows that each of the methods is extremely effective in reducing the effects of motion transients present in the data. In combination, they are able to almost completely remove the transients in the signal while preserving cardiac and low frequency information in the signal which was previously unrecoverable. This has substantially improved the stability of the physiological measures produced by the sensors in high noise conditions
Parallax and Luminosity Measurements of an L Subdwarf
We present the first parallax and luminosity measurements for an L subdwarf,
the sdL7 2MASS J05325346+8246465. Observations conducted over three years by
the USNO infrared astrometry program yield an astrometric distance of
26.7+/-1.2 pc and a proper motion of 2.6241+/-0.0018"/yr. Combined with
broadband spectral and photometric measurements, we determine a luminosity of
log(Lbol/Lsun) = -4.24+/-0.06 and Teff = 1730+/-90 K (the latter assuming an
age of 5-10 Gyr), comparable to mid-type L field dwarfs. Comparison of the
luminosity of 2MASS J05325346+8246465 to theoretical evolutionary models
indicates that its mass is just below the sustained hydrogen burning limit, and
is therefore a brown dwarf. Its kinematics indicate a ~110 Myr, retrograde
Galactic orbit which is both eccentric (3 <~ R <~ 8.5 kpc) and extends well
away from the plane (Delta_Z = +/-2 kpc), consistent with membership in the
inner halo population. The relatively bright J-band magnitude of 2MASS
J05325346+8246465 implies significantly reduced opacity in the 1.2 micron
region, consistent with inhibited condensate formation as previously proposed.
Its as yet unknown subsolar metallicity remains the primary limitation in
constraining its mass; determination of both parameters would provide a
powerful test of interior and evolutionary models for low-mass stars and brown
dwarfs.Comment: Accepted to ApJ 10 September 2007; 13 pages, 5 figures, 3 tables,
formatted in emulateapj styl
Increased cerebral blood flow in the right anterior cingulate cortex and fronto-orbital cortex during go/no-go task in children with ADHD
Objective
Arterial spin labeling (ASL) is a relatively new imaging modality in the field of the cognitive neuroscience. In the present study, we aimed to compare the dynamic regional cerebral blood flow alterations of children with ADHD and healthy controls during a neurocognitive task by using event-related ASL scanning.
Methods
The study comprised of 17 healthy controls and 20 children with ADHD. The study subjects were scanned on 3 Tesla MRI scanner to obtain ASL imaging data. Subjects performed go/no-go task during the ASL image acquisition. The image analyses were performed by FEAT (fMRI Expert Analysis Tool) Version 6.
Results
The mean age was 10.88 +/- 1.45 and 11 +/- 1.91 for the control and ADHD group, respectively (p = .112). The go/no-go task was utilized during the ASL scanning. The right anterior cingulate cortex (BA32) extending into the frontopolar and orbitofrontal cortices (BA10 and 11) displayed greater activation in ADHD children relative to the control counterparts (p < .001). With a lenient significance threshold, greater activation was revealed in the right-sided frontoparietal regions during the go session, and in the left precuneus during the no-go session.
Conclusion
These results indicate that children with ADHD needed to over-activate frontopolar cortex, anterior cingulate as well as the dorsal and ventral attention networks to compensate for the attention demanded in a given cognitive task
Trigonometric Parallaxes of Central Stars of Planetary Nebulae
Trigonometric parallaxes of 16 nearby planetary nebulae are presented,
including reduced errors for seven objects with previous initial results and
results for six new objects. The median error in the parallax is 0.42 mas, and
twelve nebulae have parallax errors less than 20 percent. The parallax for
PHL932 is found here to be smaller than was measured by Hipparcos, and this
peculiar object is discussed. Comparisons are made with other distance
estimates. The distances determined from these parallaxes tend to be
intermediate between some short distance estimates and other long estimates;
they are somewhat smaller than estimated from spectra of the central stars.
Proper motions and tangential velocities are presented. No astrometric
perturbations from unresolved close companions are detected.Comment: 24 pages, includes 4 figures. Accepted for A
The USNO-B Catalog
USNO-B is an all-sky catalog that presents positions, proper motions,
magnitudes in various optical passbands, and star/galaxy estimators for
1,042,618,261 objects derived from 3,643,201,733 separate observations. The
data were obtained from scans of 7,435 Schmidt plates taken for the various sky
surveys during the last 50 years. USNO-B1.0 is believed to provide all-sky
coverage, completeness down to V = 21, 0.2 arcsecond astrometric accuracy at
J2000, 0.3 magnitude photometric accuracy in up to five colors, and 85%
accuracy for distinguishing stars from non-stellar objects. A brief discussion
of various issues is given here, but the actual data are available from
http://www.nofs.navy.mil and other sites.Comment: Accepted by Astronomical Journa
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