Pollution from Fossil-Fuel Combustion is the Leading Environmental Threat to Global Pediatric Health and Equity: Solutions Exist

Fossil-fuel combustion by-products are the world’s most significant threat to children’s health and future and are major contributors to global inequality and environmental injustice. The emissions include a myriad of toxic air pollutants and carbon dioxide (CO2), which is the most important human-produced climate-altering greenhouse gas. Synergies between air pollution and climate change can magnify the harm to children. Impacts include impairment of cognitive and behavioral development, respiratory illness, and other chronic diseases—all of which may be “seeded“ in utero and affect health and functioning immediately and over the life course. By impairing children’s health, ability to learn, and potential to contribute to society, pollution and climate change cause children to become less resilient and the communities they live in to become less equitable. The developing fetus and young child are disproportionately affected by these exposures because of their immature defense mechanisms and rapid development, especially those in low- and middle-income countries where poverty and lack of resources compound the effects. No country is spared, however: even high-income countries, especially low-income communities and communities of color within them, are experiencing impacts of fossil fuel-related pollution, climate change and resultant widening inequality and environmental injustice. Global pediatric health is at a tipping point, with catastrophic consequences in the absence of bold action. Fortunately, technologies and interventions are at hand to reduce and prevent pollution and climate change, with large economic benefits documented or predicted. All cultures and communities share a concern for the health and well-being of present and future children: this shared value provides a politically powerful lever for action. The purpose of this commentary is to briefly review the data on the health impacts of fossil-fuel pollution, highlighting the neurodevelopmental impacts, and to briefly describe available means to achieve a low-carbon economy, and some examples of interventions that have benefited health and the economy

The Health and Well-Being of Children from the Perspective of Social and Environmental Health Policy

Environmental health is an integral component of public health and, therefore, of social welfare. Yet both social and environmental health scientists have failed to adequately consider the mutual benefits of --and synergism between-- environmental and social policies aimed at the protection of the health and well-being of children. The emerging scientific evidence that social and physical/chemical "toxicants" interact to cause childhood illness and impair children's development is providing new impetus to the integration of these disciplines. Child labor reform in the late 19th century can be seen as a milestone in the translation of science to policy. For the first time, scientific recognition of children's biological and psychological vulnerability was a major factor in shaping public policy. Yet the role of science as a force in shaping the perception of the value of the child and as a driver of reform during this period has not been widely recognized. The first paper, entitled "The Role of Science in Child Labor Reform in the Early Progressive Era (1870-1900)", describes how the growing understanding of physicians, toxicologists, sociologists, and psychologists that childhood was a biologically vulnerable period of life informed progressive reformers who used this knowledge, along with socio-economic, cultural and moral arguments, to advocate for reform. During the past several decades, there has been an exponential growth in scientific knowledge concerning the biological vulnerability of the developing fetus, infant, and child both to the toxic effects of environmental pollutants and psychosocial stressors associated with poverty or race/ethnicity. However, data are limited on the possible cumulative or synergistic effects of physical and `social' toxicants on child health and development. The second paper, entitled "Interaction between Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Maternal Psychological Distress in Pregnancy on Child Behavior ", provides new evidence of the complex consequences of environmental exposures acting in conjunction with psychosocial stressors. The specific research question addressed is whether maternal demoralization during pregnancy has a greater effect on neurobehavioral effects manifesting in childhood among children with high exposure to air pollution during gestation compared to those with low exposure. The results indicate the need for a multifaceted approach to prevention of developmental problems in children. A potential stumbling block to the integration of social and environmental policy has been the lack of adequately detailed analyses of the benefits of reducing environmental pollution. More research is needed on the monetized benefits of reducing pollution, in the overall population and as they affect less advantaged populations. The third paper entitled "Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and IQ: Estimated Cost of IQ reduction" addresses the gap in understanding of the potential economic benefits of reducing environmental pollution and estimates the increase in IQ and related lifetime earnings that would be expected in a low- income urban population as a result of a modest reduction of ambient concentrations of the combustion related pollutants, PAH. The dissertation presents these three interrelated original papers providing new evidence supporting a broad, integrated policy that addresses environmental degradation and inequality. These three papers stand on their own as original contributions to the field. By addressing three important research gaps, they provide needed evidence to support greater protection of children through an integrated social and environmental policy

A Comparison of Activity Participation between Children with and without Asthma

Background: Asthma affects approximately 6 million children in the United States and can greatly impact quality of life and occupational engagement. Although occupational therapists are well-equipped to address participation limitations, insufficient evidence exists to support the role of occupational therapists in asthma treatment. Method: The purpose of this study was to further understand the occupational limitations experienced by children with asthma. We also explored a dual diagnosis of asthma and obesity. The participants included children with (n = 84) and without (n = 63) asthma living in New York City. The Child Behavior Checklist, Youth Self Report, Brief Respiratory Questionnaire, and accelerometer data were used to examine occupational participation. Results: Although accelerometry data demonstrated that children with asthma were equally as active as their non-asthmatic peers, the participants with asthma perceived themselves as participating more in sedentary occupations and were less likely to be members of sports teams. They also had more missed school days and nights of troubled sleep. The children with both asthma and obesity reported the highest level of activity limitations. Conclusion: This study illustrates specific limitations experienced by children with asthma and supports the need for occupational therapy intervention. Future studies are needed to design and assess interventions that will support the addition of occupational therapists to multidisciplinary asthma treatment teams

Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years

Background Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age. Methods In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. The Wechsler Intelligence Scale for Children, 4th edition was administered at child age 7 years and evaluates four areas of cognitive function associated with overall intelligence quotient (IQ). Results Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = −2.69 (95% confidence interval [CI] = −4.33, −1.05) and b = −2.69 (95% CI = −4.22, −1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years. Significant inverse associations were also seen between maternal prenatal metabolite concentrations of DnBP and DiBP and child processing speed, perceptual reasoning and working memory; DiBP and child verbal comprehension; and BBzP and child perceptual reasoning. Conclusion Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children’s intellectual development at age 7 years. Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance

Prenatal Insecticide Exposures and Birth Weight and Length among an Urban Minority Cohort

We reported previously that insecticide exposures were widespread among minority women in New York City during pregnancy and that levels of the organophosphate chlorpyrifos in umbilical cord plasma were inversely associated with birth weight and length. Here we expand analyses to include additional insecticides (the organophosphate diazinon and the carbamate propoxur), a larger sample size (n = 314 mother–newborn pairs), and insecticide measurements in maternal personal air during pregnancy as well as in umbilical cord plasma at delivery. Controlling for potential confounders, we found no association between maternal personal air insecticide levels and birth weight, length, or head circumference. For each log unit increase in cord plasma chlorpyrifos levels, birth weight decreased by 42.6 g [95% confidence interval (CI), −81.8 to −3.8, p = 0.03] and birth length decreased by 0.24 cm (95% CI, −0.47 to −0.01, p = 0.04). Combined measures of (ln)cord plasma chlorpyrifos and diazinon (adjusted for relative potency) were also inversely associated with birth weight and length (p < 0.05). Birth weight averaged 186.3 g less (95% CI, −375.2 to −45.5) among newborns with the highest compared with lowest 26% of exposure levels (p = 0.01). Further, the associations between birth weight and length and cord plasma chlorpyrifos and diazinon were highly significant (p ≤ 0.007) among newborns born before the 2000–2001 U.S. Environmental Protection Agency’s regulatory actions to phase out residential use of these insecticides. Among newborns born after January 2001, exposure levels were substantially lower, and no association with fetal growth was apparent (p > 0.8). The propoxur metabolite 2-isopropoxyphenol in cord plasma was inversely associated with birth length, a finding of borderline significance (p = 0.05) after controlling for chlorpyrifos and diazinon. Results indicate that prenatal chlorpyrifos exposures have impaired fetal growth among this minority cohort and that diazinon exposures may have contributed to the effects. Findings support recent regulatory action to phase out residential uses of the insecticides