Hypoglycaemic effects of Parkia biglobosa (Jacq) Benth seed extract in glucose-loaded and NIDDM rats

The antidiabetic potentials of the methanol extract of Parkia biglobosa seed (Mimosoideae), its chloroform, hexane, and mother liquor fractions were evaluated in glucose-loaded and alloxan-induced diabetic rats. The methanol extract of the seed exhibited a peak percentage decrease of 64% and 44.1% in blood glucose levels of the glucose-loaded and alloxan-induced diabetic rats respectively. The blood glucose lowering effect of the chloroform fraction (65.7%;

Hypoglycaemic And Alpha-Amylase Inhibitory Activities Of Fermented Seeds Of Parkia Biglobosa (Jacq) Benth

Following our continuing search for plant anti-diabetic agents, we report results of a bioactivity-guided fractionation of fermented seeds of Parkiabiglobosa used in ethnomedicine in South West Nigeria to manage diabetes mellitus. An active aqueous MeOH macerate was separated by solvent partition and the bioactive CHCl3 extract fractionated on column chromatography packed with silica gel G60A, eluting with gradient mixtures of Pet ether, EtOAC and MeOH.Biologically monitored separation of extracts was achieved using alloxan-diabetic rats, glucose loading (1g/kg) and alpha-amylase inhibition assays as basis for identification of active constituent. Peak reduction (48.5%,