A local effect model-based interpolation framework for experimental nanoparticle radiosensitisation data

A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage X-ray spectra, the BAEC survival fraction response was predicted for two different AuNP concentrations and compared to experimental data. The ability of the developed framework to predict the cell survival fraction trends is analysed and discussed. This developed framework is intended to fill in the existing gaps of individual cell line response as a function of NP concentration under photon irradiation and assist the scientific community in planning future pre-clinical trials of high Z nanoparticle-enhanced photon radiotherapy

Evidence for Strong Breit Interaction in Dielectronic Recombination of Highly Charged Heavy Ions

Resonant strengths have been measured for dielectronic recombination of Li-like iodine, holmium, and bismuth using an electron beam ion trap. By observing the atomic number dependence of the state-resolved resonant strength, clear experimental evidence has been obtained that the importance of the generalized Breit interaction (GBI) effect on dielectronic recombination increases as the atomic number increases. In particular, it has been shown that the GBI effect is exceptionally strong for the recombination through the resonant state [1s2s22p1/2]1

Molecular dynamics study of accelerated ion-induced shock waves in biological media

We present a molecular dynamics study of the effects of carbon- and iron-ion induced shock waves in DNA duplexes in liquid water. We use the CHARMM force field implemented within the MBN Explorer simulation package to optimize and equilibrate DNA duplexes in liquid water boxes of different sizes and shapes. The translational and vibrational degrees of freedom of water molecules are excited according to the energy deposited by the ions and the subsequent shock waves in liquid water are simulated. The pressure waves generated are studied and compared with an analytical hydrodynamics model which serves as a benchmark for evaluating the suitability of the simulation boxes. The energy deposition in the DNA backbone bonds is also monitored as an estimation of biological damage, something which is not possible with the analytical model

Isotope Shift in the Dielectronic Recombination of Three-electron \u3csup\u3eA\u3c/sup\u3eNd⁵⁷⁺

Isotope shifts in dielectronic recombination spectra were studied for Li-like ANd57+ ions with A = 142 and A = 150. From the displacement of resonance positions energy shifts δE142 150(2s-2p1/2) = 40.2(3)(6) meV [(stat)(sys)] and δE142 150(2s - 2p3/2) = 42.3(12)(20)meV of 2s - 2pj transitions were deduced. An evaluation of these values within a full QED treatment yields a change in the mean-square charge radius of 142 150δ⟨ r2⟩ = -1.36(1)(3) fm2. The approach is conceptually new and combines the advantage of a simple atomic structure with high sensitivity to nuclear size

Color and gloss evaluation in decorative stain applied to cases of "Pinus radiata" wood treated with copper azole micronized Type C

Six treatments (one control and five decoration coatings) were applied to radiata pine wood treated with micronized copper azole for outdoor use at a rate of 3,08 kg/m3 retention. One decoration coating was applied prior to impregnation, prestain and two decoration coatings were applied in a mixture with the micronized copper azole preservative Black Cylinder and Red Cylinder. The following two varnishes were tested: a water-based varnish and a solvent-based varnish.Additionally, untreated radiata pine specimens were tested as a reference. The changes in the gloss and color of these five decorative coatings were evaluated after undergoing natural aging tests for three months and accelerated aging trials during exposure to ultra-violet radiation of 340 nm for 500 hours. In the accelerated aging trials treatments, changes in gloss and color showed the lowest variations in treatment trials prestain and Black Cylinder and the highest variations in treatment trial Red Cylinder. In the aging tests trials, changes in gloss and color showed the lowest variations in treatment trials prestain and Black Cylinder. The costs of each decorative coating were assessed in terms of performance according to timber volume coated. The lowest cost of the three decoration treatments was prestain, with a value of 16 US$/m3, followed by Black Cylinder with a value of 24 US$/m3. Compared with the alternative siding products available in the market, such as fiber cement and vinyl siding, colored wood treated with prestain is competitive with vinyl siding, with 58% lower costs than fiber-cement