A double-blind randomized trial of nicotine nasal spray as an aid in smoking cessation

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe objective of the study was to evaluate the therapeutic efficacy of nicotine nasal solution (NNS) for smoking cessation from the stopping day up to 3 months. We also followed the participants for 2 yrs after ceasing smoking to assess what happens after stopping using NNS. In a placebo-controlled, double-blind, 2 yr prospective study, 157 smokers were given either NNS, one dose containing 1 mg of nicotine per 100 microL (n=79), or placebo (n=78). Treatment was continued for up to 1 yr. One day after quitting smoking, the average number of daily doses was 11 in the group assigned NNS and 14 in the group assigned the placebo, and after 6 weeks, 14 and 6 doses, respectively, among abstinent participants still using spray. After 3 months, 65% of the abstainers in the nicotine group were still using the NNS. The abstinence rates were 51, 39 and 29% after 6 weeks, 3 and 6 months, respectively, as compared to 24, 19 and 18% in the placebo group (p=0.0003; p=0.003; p=0.050). The proportion abstinent at the 1 yr (25 vs 17%) and 2 yr follow-ups (19 vs 14%) was higher among those assigned to the nicotine than to the placebo group, but not significantly so for the numbers used in the study. In conclusion, the use of nicotine nasal spray significantly increased the abstinence rate during the first 6 months following the quitting day

Epilepsia de lobo temporal na infância: artigo de revisão

INTRODUCTION: The authors present a review article on temporal lobe epilepsy in childhood. METHODS: We performed a search in the literature. RESULTS: The main etiologies of temporal lobe epilepsy in childhood are developmental tumors and focal cortical displasia, besides temporal medial sclerosis. The clinical features may be variable particularly in children younger than six years of age. Epilepsy may present with generalized seizures. Electroencephalographic findings are also variable and show a functional dysfunction of several brain areas besides temporal lobes, especially frontal lobes. CONCLUSION: Recent advances demonstrate that temporal lobe epilepsy in childhood present with great etiologic, clinical and electroencephalographic diversity.INTRODUÇÃO: As autoras apresentam um artigo de revisão sobre epilepsia de lobo temporal na infância. MATERIAL E MÉTODOS: Realizou-se levantamento bibliográfico sobre o assunto, acrescido de contribuições pessoais. RESULTADOS: As principais etiologias da epilepsia de lobo temporal na infância são tumores do desenvolvimento e displasias corticais focais, além de esclerose mesial temporal. O quadro clínico é florido em crianças menores de seis anos e pode cursar com crises generalizadas. Os achados eletrencefalográficos também são variáveis e apontam para o comprometimento funcional de outras áreas cerebrais além dos lobos temporais, particularmente os lobos frontais. CONCLUSÃO: Avanços recentes mostram que a epilepsia de lobo temporal na infância apresenta grande diversidade etiológica, clínica e eletrencefalográfica.263

Banco ativo de germoplasma de fruteiras nativas do Sul do Brasil.

bitstream/item/61941/1/FOLDER-BANCO-ATIVO-DE-GERMOPLASMA-DE-FRUTEIRAS-NATIVAS-DO-SUL-DO-BRASIL.pd

Marcadores AFLP no estudo da variabilidade genética de populações de pitangueira (Eugenia uniflora L.)

bitstream/item/78661/1/Boletim-151.pd

Banco ativo de germoplasma de prunóides.

bitstream/item/61948/1/Folder-Banco-ativo-de-germoplasma-de-prunoideas-Copia.pd