Studies of Heart Development in Normal and Cardiac Lethal Mutant Axolotls: A Review

The morphology of developing hearts in axolotls, Ambystoma mexicanum, has been studied by scanning electron microscopy in order to provide a chronology of morphogenesis that can be correlated with ongoing biochemical and immunocytochemical studies. In addition to normal embryos we have studied homozygous recessive cardiac lethal mutant axolotls. The mutant myocardium undergoes aberrant sarcomere development and lacks a normal heartbeat. Morphogenesis of mutant hearts appears to be nearly normal with respect to myocardial cell shape changes, epicardial formation, and the distribution of extracellular matrix fibrils in the cardiac jelly. This suggests that the deficient arrangement of contractile proteins in mutant myocardial cells does not prevent the normal organization or function of cytoskeletal isoforms of these proteins in the developing myocardium and epicardium. The implications of biochemical and morphological investigations of axolotl hearts are considered in the context of the entire developmental history of the cardiogenic mesoderm

"Wil je snel gaan, ga alleen, wil je ver komen ga dan samen" : onderwijsdag ondernemerschap 21 januari 2010

Overzicht van diverse vormen van samenwerking en samenwerkingsprojecten die aan bod zijn gekomen tijdens de Onderwijsdag Ondernemerscha

Tempering Transnational Advocacy?:The Effect of Repression and Regulatory Restriction on Transnational NGO Collaborations

This paper examines through qualitative study the effect of government regulatory restriction and repression on non-governmental organizations (NGOs) engaging in transnational advocacy. The focus is on NGO’s advocacy activities, in the realm of human rights, environment, labor and development in particular, using illustrations from Bangladesh and Zambia. It finds that next to some NGOs disbanding and moving towards service activities, many NGOs shift in terms of substantive advocacy and form of organizational collaboration. To continue cross-border interactions with their foreign partners, many NGOs adjust to circumvent or compensate for restrictions and repression. Because of this, transnational advocacy can be said to continue, but repression and restrictions have significant substantive and organizational effects for the collaborations studied, and cross-border NGO collaborations in our sample are increasingly fragile and their advocacy more tempered