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Jan Weyts, Frans Brouwers en Johan De Punt Getijdenwatermolens van Rupelmonde en Bergen op Zoom. [Tide mills of Rupelmonde and Bergen Op Zoom.]De getijdenwatermolens van Rupelmonde en van Bergen op Zoom zijn zeldzame relicten van een specifiek type van watermolens. Ze waren eertijds terug te vinden langsheen de West-Europese kusten en ook op rivieren waar de getijden zich voldoende lieten gevoelen. Jan Weyts, Frans Brouwers en Johan de Punt bundelden hun expertise om dit erfgoed levend te houden en hun werking voor te stellen.Dieter Nuytten Bouwgeschiedenis en restauratie van de Mariapoort van de Parkabdij in Heverlee. [Building history and restoration of the gate of Mary in the Heverlee park abbey.]Om de abtswoning van de Parkabdij van Heverlee te bereiken, moest de bezoeker doorheen een indrukwekkend aantal toegangspoorten. Dieter Nuytten blijft even stilstaan bij de Mariapoort, niet meteen het meest monumentale poortgebouw van de abdij, maar wel een relict met een bewogen verleden, talrijke verbouwingen en wijzigingen, en tenslotte een nieuwe restauratie met herstel van het oorspronkelijke mansardedak.Anne Dompas Het kerkschip van Antwerpen, een drijvend betonnen monument. [The church ship in Antwerp: a floating concrete monument.]Niet meteen het meest voor de hand liggende materiaal om een boot drijvend te houden, speelde beton nochtans een vooraanstaande rol in periodes van materiaal schaarste tijdens en tussen de beide wereldoorlogen. Anne Dompas loodst ons met kennis van zaken doorheen allerhande experimenten met dit gewapend materiaal, dat oorspronkelijk gebruikt werd voor het vervaardigen van rustieke tuinornamenten.Summar

Cervical epidural steroid injections in the management of cervical radiculitis: interlaminar versus transforaminal. A review

There has been recent concern regarding the safety of cervical epidural steroid injections. The decision to proceed with treatment requires balancing the risk and benefits. This article is an in depth review of the efficacy, complications, and technique of both interlaminar and transforaminal cervical epidural steroid injections in the management of cervical radiculitis

Chinese architectural practice and the spatial discourse of Vancouver's Chinatown

The thesis examines Chinese architectural practice within the city of Vancouver as a means of identifying the historical extent of Chinese lived social space and to challenge the notion that Vancouver's Chinatown existed as a clear and separate spatial category. By using a definition of space that includes its temporal dimension the thesis argues that Chinatown spatially is a dynamic phenomenon that has exhibited tremendous changes over the last 130 years. The intention of the thesis is two part, first it illustrates the historical significance of early Chinese architectural practice, and secondly, it begins to construct a spatial discourse that considers the totality of Chinese lived social space and its influence on the formation of the city of Vancouver. The research specifically examines Chinese hybrid architectural practices that have been organized as a genealogy in an attempt to provide a means to identify and explain multiple points of origin from multiple sources. These practices have been placed within a series of maps defined by the Canadian Pacific Railway's subdivision of District Lot 196 and include Chinese land occupation, city zoning boundaries and major urban development proposals. The study is divided into fourteen discrete architectural cases. Although the cases are organized into three general periods the intention of the research is to identify the specific historical and contextual circumstances that produced and inform each case. The intention was to identify how hybrid architectural practices were used to negotiate space and produce new social practices. The thesis reaffirms the social, historical and cultural significance of the architecture produced around the area identified as Chinatown. The area is populated with a number of historically significant buildings, comprising a number of distinct architectural practices that have produced some unique spatial conditions. The study also clearly refutes the conceptualization of Chinatown as a coherent or accurate historical image of Chinese lived social space within the city of Vancouver. The research identifies fundamental problems in the conception and historical description of Chinatown as a discretely defined space.Applied Science, Faculty ofArchitecture and Landscape Architecture (SALA), School ofGraduat

Transgenic Artifacts Caused by Passenger Human Growth Hormone

The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here the mouse lines in which ectopic hGH has been confirmed, and we provide a wiki for lines awaiting analysis.status: publishe

Inhibition of Sglt2-mediated streptozotocin uptake reduces direct renal toxicity in a mouse model for diabetic nephropathy

status: accepte

Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity

The proprotein convertase 1/3 (PC1/3), encoded by PCSK1, cleaves and hence activates several orexigenic and anorexigenic proproteins. Congenital inactivation of PCSK1 leads to obesity in human but not in mice. However, a mouse model harboring the hypomorphic mutation N222D is obese. It is not clear why the mouse models differ in phenotype.status: publishe

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been suggested, a comprehensive explanation is still lacking. In this study we examined the molecular mechanisms leading to this compound phenotype. Upon generation of the Nestin-Cre mice, the human growth hormone (hGH) minigene was inserted downstream of the Cre recombinase to ensure efficient transgene expression. As a result, hGH is expressed in the hypothalamus. This results in the auto/paracrine activation of the GH receptor as demonstrated by the increased phosphorylation of signal transducer and activator of transcription 5 (STAT5) and reduced expression of growth hormone releasing hormone (Ghrh). Low Ghrh levels cause hypopituitarism consistent with the observed mouse growth hormone (mGH) deficiency. mGH deficiency caused reduced activation of the GH receptor and hence reduced phosphorylation of STAT5 in the liver. This led to decreased levels of hepatic Igf-1 mRNA and consequently postnatal growth retardation. Furthermore, genes involved in lipid uptake and synthesis, such as CD36 and very low-density lipoprotein receptor were upregulated, resulting in liver steatosis. In conclusion, this study demonstrates the unexpected expression of hGH in the hypothalamus of Nestin-Cre mice which is able to activate both the GH receptor and the prolactin receptor. Increased hypothalamic GH receptor signaling explains the observed hypopituitarism, reduced growth and metabolic phenotype of Nestin-Cre mice. Activation of either receptor is consistent with reduced anxiety.status: publishe